Abstract：
BACKGROUND:The clinicopathologic characteristics and the expression of apomucin (MUC) in intrahepatic cholangiocarcinoma (ICC) with respect to gross morphology have not been comprehensively examined. STUDY DESIGN:We reviewed the clinical data of 98 patients with ICC who underwent resection at Seoul National University Hospital from 1980 to 1998. We also examined the expression profiles of MUC1 and MUC2 in 30 ICC tissues by immunohistochemistry using mouse monoclonal antibodies. RESULTS:Of 98 cases, 42 were of the mass-forming type of ICC, 22 were of the periductal-infiltrating type, 21 were of the intraductal-growth (IG) type, and 13 were of the mixed type, and the overall 5-year cumulative survival rate was 23.3% in the mass-forming type, 0% in the periductal-infiltrating type, and 76.2% in the IG type. MUC1 was expressed in all types (mass-forming type 75.0%, periductal-infiltrating type 100%, and IG type 73.3%), but significantly, MUC2 was expressed only in the IG type (80.0%), which had better prognosis than the other types. CONCLUSIONS:It is apparent that the IG type of ICC should be distinguished from the other types of ICC because a favorable prognosis can be expected after complete surgical resection.
journal_name
J Am Coll Surgjournal_title
Journal of the American College of Surgeonsauthors
Suh KS,Chang SH,Lee HJ,Roh HR,Kim SH,Lee KUdoi
10.1016/s1072-7515(02)01343-1keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
782-9issue
6eissn
1072-7515issn
1879-1190pii
S1072-7515(02)01343-1journal_volume
195pub_type
杂志文章abstract：BACKGROUND:To determine prospectively if simulator-based laparoscopic training could improve laparoscopic skills of gynecology residents. STUDY DESIGN:Twenty-six gynecology residents were enrolled in a laparoscopy training curriculum involving didactics, self-paced learning modules, and graded simulator-based laparosc...
journal_title：Journal of the American College of Surgeons
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journal_title：Journal of the American College of Surgeons
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更新日期：1994-12-01 00:00:00
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