Abstract：
:In this study we demonstrate the importance of distributed sampling of peristimulus time in blocked design fMRI studies. Distributed sampling ensures all the components of an event-related hemodynamic response are sampled and avoids the bias incurred when stimulus presentation is time-locked to data acquisition. We found that differences in the temporal offset between stimulus presentation and data acquisition had a significant effect on some language-related activations. These effects, induced by simply shifting stimulus presentation by a fraction of the interscan interval, suggest that fixed sampling does indeed bias estimated responses, even in blocked designs.
journal_name
Neuroimagejournal_title
NeuroImageauthors
Veltman DJ,Mechelli A,Friston KJ,Price CJdoi
10.1006/nimg.2002.1242keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
1203-6issue
3eissn
1053-8119issn
1095-9572pii
S1053811902912425journal_volume
17pub_type
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