Abstract:
:The genetic analysis of simple Mendelian epilepsies remains a key strategy in advancing our understanding of epilepsy. In this article, we describe a new family epilepsy syndrome, partial epilepsy with pericentral spikes, which we map to chromosome 4p15. We distinguish it clinically, electrophysiologically, and genetically from previously described Mendelian epilepsies. The family described is a large Brazilian kindred of Portuguese extraction in which affected family members manifest a variety of seizure types, including hemiclonic, hemitonic, generalized tonic-clonic, simple partial (stereotyped episodes of epigastric pain), and complex partial seizures consistent with temporal lobe epilepsy. The syndrome is benign, either requiring no treatment or responding to a single antiepileptic medication. Seizure onset is in the first or second decades of life, with seizures in individuals up to the age of 71 years and documented encephalogram changes up to the age of 30 years. A key feature of partial epilepsy with pericentral spikes is a characteristic encephalogram abnormality of spikes or sharp waves in the pericentral region (centroparietal, centrofrontal, or centrotemporal). This distinctive encephalogram abnormality of pericentral spikes unites these several seizure types into a discrete family epilepsy syndrome. As with other familial epilepsies, the inherited nature of this new syndrome may be overlooked because of the variability in penetrance and seizure types among affected family members.
journal_name
Ann Neuroljournal_title
Annals of neurologyauthors
Kinton L,Johnson MR,Smith SJ,Farrell F,Stevens J,Rance JB,Claudino AM,Duncan JS,Davis MB,Wood NW,Sander JWdoi
10.1002/ana.10221keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
740-9issue
6eissn
0364-5134issn
1531-8249journal_volume
51pub_type
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abstract:OBJECTIVE:Human immunodeficiency virus (HIV) infection of the central nervous system (CNS) is frequently associated with intrathecal immunoglobulin synthesis and cerebrospinal fluid (CSF) pleocytosis, but little is known about the B-cell response in the CSF of these patients. In this study, we investigated the relation...
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更新日期:2007-11-01 00:00:00
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更新日期:1992-12-01 00:00:00
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更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410350422
更新日期:1994-04-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1995-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410070409
更新日期:1980-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ana.410230213
更新日期:1988-02-01 00:00:00
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更新日期:2004-03-01 00:00:00
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更新日期:1982-03-01 00:00:00
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更新日期:1998-01-01 00:00:00
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更新日期:2018-09-01 00:00:00
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更新日期:1997-10-01 00:00:00
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更新日期:1994-08-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2014-07-01 00:00:00
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更新日期:2013-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-05-01 00:00:00
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更新日期:2003-05-01 00:00:00
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更新日期:2016-04-01 00:00:00