Reduction in postoperative pain after spinal fusion with instrumentation using intrathecal morphine.

Abstract:

STUDY DESIGN:The efficacy of intrathecal (spinal) morphine in the treatment of pain after posterior spinal fusions was assessed. OBJECTIVE:To investigate improved posterior pain control with fewer side effects in patients with posterior spinal fusions. SUMMARY OF BACKGROUND DATA:After multilevel spinal fusion with instrumentation, patients experience considerable pain that is difficult to treat. METHODS:For this study, 65 patients undergoing elective multilevel posterior spinal instrumentation were randomized to receive spinal morphine as follows: 10 microgram/kg, 20 microgram/kg, or none. These patients were assessed after surgery for pain control and narcotic-associated complications. RESULTS:The patients who received 20 microgram/kg of spinal morphine were more comfortable immediately after surgery, remained pain free for a longer period, and required significantly less additional narcotic. These patients also had fewer respiratory complications. CONCLUSIONS:Relatively high-dose spinal morphine administration provides simple, reliable postoperative pain control after posterior spinal fusions. This may contribute to reduced postoperative respiratory morbidity and an improved outcome.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Urban MK,Jules-Elysee K,Urquhart B,Cammisa FP,Boachie-Adjei O

doi

10.1097/00007632-200203010-00015

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

535-7

issue

5

eissn

0362-2436

issn

1528-1159

journal_volume

27

pub_type

临床试验,杂志文章,随机对照试验

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