Abstract：
:We showed previously that treatment of gamma-irradiated female B6D2F1 mice with 5-androstenediol (AED) enhanced survival, stimulated myelopoiesis, and ameliorated radiation-induced decreases in circulating neutrophils and platelets. We have now tested survival in male CD2F1 mice, and we have investigated molecular and functional effects on neutrophils and bone marrow stromal cells and screened for toxicity in female B6D2F1 mice. AED (160 mg/kg, subcutaneously, 24 hours before irradiation) enhanced survival in male CD2F1 mice with a dose-reduction factor of 1.23, similar to the dose-reduction factor of 1.26 found previously for female B6D2F1 mice. Expression of CD11b, a developmental marker, was reduced on circulating neutrophils after either in vivo AED administration or whole-body gamma-irradiation (3 Gy), but neutrophil peroxidase activity was unchanged. Stromal cell progenitors (fibroblastoid colony-forming units) were reduced in marrow 5 days after AED injection in nonirradiated mice. Clinical chemistry, histopathology, and behavioral assays showed no evidence of toxicity. We conclude that AED and related steroids are attractive candidates to explore as countermeasures to high- and low-level ionizing radiation.
journal_name
Mil Medjournal_title
Military medicineauthors
Whitnall MH,Elliott TB,Landauer MR,Wilhelmsen CL,McKinney L,Kumar KS,Srinivasan V,Ledney GD,Seed TMkeywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
64-5issue
2 Suppleissn
0026-4075issn
1930-613Xjournal_volume
167pub_type
杂志文章abstract：:The Navy Reserve Nurse Corps faces a nursing shortage that reflects the national picture and holds major implications for the military patient care readiness of this nation. This account of the changing climate of nursing practice in the Navy Reserves offers observations on recruitment and retention strategies for the...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:An estimated 400,000 non-melanoma skin cancers occur each year. A majority of them will develop on sun-exposed areas of the face, head, and neck. By virtue of having assignments that involve outdoor duty, often in areas of high ultraviolet radiation exposure, military personnel are at increased risk of developing thes...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:A 30-year review of the Armed Forces Tumor Registry revealed that of 3,126 thyroid cancers on file, 82 were in the pediatric population. All of these cases were reviewed, and the mean age was found to be 13.8 years. There as a male-to-female ratio of 1:2.3. At the time of diagnosis, 33% had regional nodes and 6% had d...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:Typical military tasks include load carriage, digging, and lifting loads. To avoid accumulation of fatigue, it is important to know the energy expenditure of soldiers during such tasks. The purpose of this study was to measure cardiorespiratory responses during military tasks in field conditions. Unloaded (M1) and loa...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-13-00299
更新日期：2014-02-01 00:00:00
abstract：:Several international legal instruments and ethical guidelines bestow rights and impose duties on detainees and military physicians, respectively. Ideological totalism, moral disengagement, and victim blame can facilitate the abuse of detainees, and this mindset must be avoided by military physicians. Physicians shoul...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.173.supplement_2.15
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:The command of a U.S. Army Reserve Combat Support Hospital designed this study to evaluate soldiers' behavior related to and attitudes toward skipping meals while on annual training (AT). METHODS:The command administered an anonymous survey on attitudes about weight loss and weightloss behavior while on AT. ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.171.7.678
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVES:The study establishes the functional outcomes of service personnel injured in current conflicts by correlating data on initial injury to the findings of medical boards after trauma and reconstructive treatment. Data comprehensively include all casualties of the Royal Navy and Royal Marines and all functional...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-13-00180
更新日期：2013-11-01 00:00:00
abstract：:In this report, we describe the organizational framework, operations and current status of the Central Simulation Committee (CSC). The CSC was established in 2007 with the goals of standardizing simulation-based training in Army graduate medical education programs, assisting in redeployment training of physicians retu...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed-d-12-00065
更新日期：2012-07-01 00:00:00
abstract：INTRODUCTION:Emergency department (ED) utilization represents an expensive and growing means of accessing care for a variety of conditions. Prior studies have characterized ED utilization in the general population. We aim to identify the clinical conditions that drive ED utilization in a universally insured population ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa547
更新日期：2020-12-17 00:00:00
abstract：Introduction:Mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) are common military service-related conditions diagnosed both singly and together in veterans returning from recent military conflicts overseas. The impact of these disorders in real-world Veterans Health Administration practice h...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usx050
更新日期：2018-03-01 00:00:00
abstract：:The purpose of this study was to examine changes in select anaerobic and aerobic dependent physical performance tasks in U.S. Marines exposured to field operations at moderate altitude. The subjects (N = 16) completed Wingate anaerobic power, submaximal aerobic cycle ergometry, hand grip strength, and push-up tests on...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:This study explores what factors influence whether active duty U.S. military personnel enroll their families in Department of Defense (DoD) or non-DoD dental insurance plans. The data come from a 26-site, cross-sectional survey of U.S. service members conducted from April 1994 to January 1995. A prestratified, randoml...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：PURPOSE:To explore response to vitamin D supplementation in active duty (AD) warfighters and translate findings into evidence-based health policy. BACKGROUND:Soldiers are at risk for musculoskeletal injuries and metabolic dysfunction that impact physical performance and military readiness; the link with low vitamin D ...
journal_title：Military medicine
pub_type： 杂志文章,随机对照试验
doi：10.1093/milmed/usy393
更新日期：2019-03-01 00:00:00
abstract：:A case report of an army soldier presenting to the emergency department with acute metabolic derangement resulting in encephalopathy, cerebral edema, and death is presented. The patient had no medical diagnoses before entering military service and was triaged in the emergency department with the common complaint of pr...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa402
更新日期：2020-11-19 00:00:00
abstract：INTRODUCTION:Gestational diabetes mellitus (GDM) affects approximately 1-14% of all pregnancies in the United States and has significant maternal and neonatal consequences. Developing GDM can increase a patient's risk of developing overt diabetes in the future which may impact a soldier's readiness. The purpose of this...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa400
更新日期：2020-11-24 00:00:00
abstract：:As researchers examine the efficacy of interventions that simultaneously target more than 1 symptom, it is important to identify ways to help guide research and program development. This study used electronic medical record data to examine the covariation of multiple risk factors regularly assessed among primary care ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-14-00119
更新日期：2014-10-01 00:00:00
abstract：:Hip fractures in the young are exceedingly rare and are usually seen in instances of high energy trauma or metabolically altered bone states. In this case report, we present an occult femoral neck fracture, diagnosed by magnetic resonance imaging, in an otherwise healthy, young, active duty male patient with an isolat...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed-d-11-00321
更新日期：2012-05-01 00:00:00
abstract：:The United States Army Europe Stress Management Team (USAREUR SMT) is designed to assist victims of hostage, terrorist, and disaster situations. Early intervention is intended to prevent the development of chronic posttraumatic stress disorder. This paper describes the operation of the SMT following the missile attack...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:Data from 12 Department of Veterans Affairs patients hospitalized for status asthmaticus were analyzed to determine the rate and degree of response to therapy. The time to achieve recovery was directly related to the level of baseline obstruction at the time of hospital admission. The recovery rate was constant and co...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:This study profiles tobacco use by 2,241 dependent teenagers in grades 6-12 at two Army posts. Data were collected in February 1989 by self-administered questionnaires. Results show 40.9% of dependent teenagers have tried smoking and 16.4% have tried smokeless tobacco. Most youths who tried tobacco did so experimental...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:While on the surface the future of military GME appears uncertain, closer inspection demonstrates opportunities to achieve excellence in education. In many cases, programs will emerge with larger and more diverse faculty and increased collaboration with local institutions. On an individual level, military faculty will...
journal_title：Military medicine
pub_type： 社论
doi：
更新日期：2006-03-01 00:00:00
abstract：:The development of more effective medical simulators requires a collaborative team effort where three kinds of expertise are carefully coordinated: (1) exceptional medical expertise focused on providing complete and accurate information about the medical challenges (i.e., critical skills and knowledge) to be simulated...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-13-00265
更新日期：2013-10-01 00:00:00
abstract：:Severely injured patients have difficulty recalling their intensive care unit (ICU) experience which may contribute to emotional trauma. An ICU patient journal contains a short summary of key events during the ICU stay, and has been shown to improve emotional well-being. This project evaluated the feasibility and perc...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/MILMED-D-15-00210
更新日期：2016-08-01 00:00:00
abstract：:Ankle-arm index (AAI) and pulse volume recording (PVR) are commonly used in the early postoperative period to measure the outcome after lower-extremity revascularization. They are also used in addition to duplex scan for long-term follow-up of these patients. We noticed that in some patients the AAI and/or PVR after r...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：1997-04-01 00:00:00
abstract：BACKGROUND:Reorganization of the Army and critical assessment of Army Graduate Medical Education programs prompted the Occupational and Environmental Medicine (OEM) Consultant to the Army Surgeon General to initiate a review of current Army OEM residency training. Available information indicated the Army OEM residency ...
journal_title：Military medicine
pub_type： 历史文章,杂志文章
doi：10.7205/MILMED-D-16-00118
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:A new training and rehabilitation methodology called Sanomechanics® is presented based on a recent discovery of the anatomical system called Floating Skeleton System (FSS) responsible for redistributing contact pressures in the joint capsules and thus minimizing the loads on joint cartilages. MATERIALS AND ...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.1093/milmed/usaa476
更新日期：2021-01-25 00:00:00
abstract：:Ambulatory care federal pharmacists may be readily used by beneficiaries to obtain verbal and written pharmaceutical and/or medical information because of their high visibility and accessibility. In addition to information provided for prescription medications, pharmacists may provide medication and disease informatio...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:The work of the War Hospital in Tomislavgrad during the war in Bosnia and Herzegovina from 1992 to 1995 is described. The War Hospital in Tomislavgrad was one of the first medical institutions organized in Bosnia and Herzegovina, with the intention of providing surgical treatment and care to soldiers, local civilians,...
journal_title：Military medicine
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:Potential health issues arising from embedded metal fragment injuries are an operational health issue in the military medical community. Embedded fragment injuries can occur not only from standard-use munitions, but also from improvised explosive devices (IEDs). With few exceptions, the behavior of metal fragments, wh...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed-d-02-2808
更新日期：2009-03-01 00:00:00
abstract：:The purpose of this study was to investigate an outbreak of tuberculosis (TB) in a bacillus Calmette-Guérin-vaccinated military population and propose an appropriate method of control. We divided 593 subjects into "close contacts" and "non-close contacts" of an index case and examined all subjects by chest X-radiograp...
journal_title：Military medicine
pub_type： 杂志文章
doi：10.7205/milmed.173.4.388
更新日期：2008-04-01 00:00:00
