Treatment options in Waldenström's macroglobulinaemia: the role of the purine analogues.

abstract：INTRODUCTION:Bipolar disorder is characterized by mood instability, which can be challenging to manage. First-line pharmacological approaches usually involve lithium, anticonvulsants and antipsychotics. Over the past fifteen years, several second-generation antipsychotics have demonstrated benefits for various phases o...

journal_title：Expert opinion on pharmacotherapy

authors： Janicak PG,Rado JT

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14α-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic met...

journal_title：Expert opinion on pharmacotherapy

authors： Piérard GE,Hermanns-Lê T,Delvenne P,Piérard-Franchimont C

更新日期：2012-06-01 00:00:00

abstract：:Although panic disorder usually emerges in early to middle adulthood, adults with panic disorder often retrospectively report that their panic symptoms began in childhood or early adolescence. The majority of these juvenile cases are being misdiagnosed, and/or do not come to clinical attention. Awareness of early-onse...

journal_title：Expert opinion on pharmacotherapy

authors： Masi G,Pari C,Millepiedi S

更新日期：2006-04-01 00:00:00

abstract：INTRODUCTION:For more than two decades, lowering levels of low-density lipoprotein cholesterol has formed the cornerstone of management of patients with atherosclerotic cardiovascular disease. The substantial residual risk of clinical events in patients treated with statin therapy highlights the need to develop more ef...

journal_title：Expert opinion on pharmacotherapy

authors： Nicholls SJ,Pisaniello AD,Kataoka Y,Puri R

更新日期：2014-06-01 00:00:00

abstract：:Erectile dysfunction (ED) has serious negative consequences on both sexual experience and emotional well being and affects a broad range of age groups. The prevalence of ED is associated with increasing age and has been reported to be as high as 70%. Although the disorder is common and underdiagnosed, its treatment ca...

journal_title：Expert opinion on pharmacotherapy

authors： Becher E

更新日期：2004-03-01 00:00:00

abstract：INTRODUCTION:: Despite treatment with antipsychotic medication, approximately 1/3 of individuals with schizophrenia will fail to have an adequate response. To treat these patients, a commonly utilized approach is antipsychotic combination therapy. Antipsychotic combination therapy is controversial with mixed efficacy a...

journal_title：Expert opinion on pharmacotherapy

authors： Faden J,Kiryankova-Dalseth N,Barghini R,Citrome L

更新日期：2020-11-30 00:00:00

abstract：INTRODUCTION:Breast cancer is a common, life-threatening disease among women. Contemporary hormonal therapy with third-generation aromatase inhibitors for estrogen-receptor-positive breast cancers in postmenopausal women is still facing the challenge of interpatient variability in therapeutic response and intensity of ...

journal_title：Expert opinion on pharmacotherapy

authors： Turkistani A,Marsh S

更新日期：2012-06-01 00:00:00

abstract：:Primary and secondary prevention of venous thromboembolism (VTE) are the major roles of anti-thrombotic therapy in patients with cancer. Although the choices of pharmacological agents remain limited, low molecular weight heparins (LMWHs) offer important advantages over traditional anticoagulants. For prophylaxis in th...

journal_title：Expert opinion on pharmacotherapy

authors： Lee AY

更新日期：2003-12-01 00:00:00

abstract：:The aim of this review is to provide a rationale for evaluating thiazolidinediones (TZDs) as putative treatments for cognitive deficits in individuals with mood disorders. A MedLine search of all English-language articles published between January 1966 and August 2006 was conducted. The search terms were: the non-prop...

journal_title：Expert opinion on pharmacotherapy

authors： McIntyre RS,Soczynska JK,Woldeyohannes HO,Lewis GF,Leiter LA,MacQueen GM,Miranda A,Fulgosi D,Konarski JZ,Kennedy SH

更新日期：2007-08-01 00:00:00

abstract：:Cervical dystonia (CD) manifests clinically through involuntary spasms of neck muscles, producing abnormal head and neck movements and postures, which is often associated with pain. CD is the most common form of focal dystonia presenting to movement disorders clinics. Chemodenervation with botulinum toxin (BTX) has be...

journal_title：Expert opinion on pharmacotherapy

authors： Tintner R,Jankovic J

更新日期：2001-12-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) can spontaneously improve during pregnancy. However, a considerable proportion of patients can experience a flare and high disease activity has been associated with an increased risk of adverse pregnancy outcome. Thus, the treatment of RA in pregnant women should be selected takin...

journal_title：Expert opinion on pharmacotherapy

authors： Gerosa M,Schioppo T,Meroni PL

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:During the past decade, there have been significant advances in the pharmacotherapies for the treatment of diabetic macular edema (DME). Among the presently available treatment options, anti-vascular endothelial growth factors (anti-VEGF) agents are the most favored agents due to their efficacy and safety....

journal_title：Expert opinion on pharmacotherapy

authors： Agarwal A,Parriott J,Demirel S,Argo C,Sepah YJ,Do DV,Nguyen QD

更新日期：2015-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACE-Is) are an evidence-based treatment for patients who after myocardial infarction (MI) present with either heart failure (HF) or left ventricular systolic dysfunction, or both. An alternative could be a more complete inhibition of the renin-angiotensin system through the bl...

journal_title：Expert opinion on pharmacotherapy

authors： Maggioni AP,Fabbri G

更新日期：2005-03-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Inhibition of the aromatase enzyme in postmenopausal women reduces levels of estrogens, which is of therapeutic value in hormone-sensitive breast cancer. Exemestane is a third-generation steroidal irreversible inactivator of the aromatase enzyme used in early and advanced breast cancer for the t...

journal_title：Expert opinion on pharmacotherapy

authors： Bertelli G,Gangadhara S

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Fampridine-SR is under submission as the first drug to be FDA approved with an indication specifically for multiple sclerosis symptoms. Compounded forms of the active agent of Fampridine-SR (4-aminopyridine) have been used in clinical practice for many years. Clinical trials have now been completed that demo...

journal_title：Expert opinion on pharmacotherapy

authors： Kachuck NJ

更新日期：2009-08-01 00:00:00

abstract：:This paper describes the functional roles of the closely related pharmacogenetic and pharmacogenomic sciences in medicine. Firstly, they provide means for a better understanding of the function of drugs, and particularly of the differences of drug action between individuals and also between racially categorised popula...

journal_title：Expert opinion on pharmacotherapy

authors： Kalow W

更新日期：2005-07-01 00:00:00

abstract：:This editorial considers the use of the first selective oral renin inhibitor, aliskiren, in reducing angiotensin (Ang) II reactivation or aldosterone (ALDO) escape during renin-angiotensin-aldosterone system (RAAS) inhibition. RAAS blockade with angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin recep...

journal_title：Expert opinion on pharmacotherapy

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Tziomalos K,Karagiannis A

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:Intravenous (I.V.) morphine administered through a patient-controlled system currently represents the gold standard treatment for moderate to severe acute postoperative pain. To fix the limitations showed by the available I.V. patient-controlled analgesia (PCA) systems that may restrict its use in the clin...

journal_title：Expert opinion on pharmacotherapy

authors： Fanelli A,Sorella MC,Chelly JE

更新日期：2016-01-01 00:00:00

abstract：:Several studies have revealed the intimate associations between erectile dysfunction (ED), ischemic heart disease (IHD) and depression. Whether the physicians should also screen for the other two components when a patient presents with one component of this triad is still an important question to be answered. These th...

journal_title：Expert opinion on pharmacotherapy

authors： El-Sakka AI,Shamloul R,Yassin AA

更新日期：2009-09-01 00:00:00

abstract：:Glatiramer acetate (Copaxone, Teva Pharmaceuticals Ltd) is a collection of immunomodulatory, synthetic polypeptides indicated for the treatment of relapsing-remitting multiple sclerosis (RR MS). Preclinical and clinical studies provide an evolving understanding of the mechanisms by which glatiramer acetate exerts both...

journal_title：Expert opinion on pharmacotherapy

authors： Wolinsky JS

更新日期：2004-04-01 00:00:00

abstract：INTRODUCTION:The majority of patients with type 1 diabetes mellitus (T1DM) do not achieve glycemic targets. In addition, treatment with insulin is associated with increased risk for hypoglycemia and weight gain. Accordingly, there is an unmet need for new safe and effective glucose-lowering agents in this population. S...

journal_title：Expert opinion on pharmacotherapy

authors： Chatzopoulos G,Tziomalos K

更新日期：2020-10-01 00:00:00

abstract：:Autonomic dysreflexia is a potentially life-threatening hypertensive medical emergency that occurs most often in spinal cord-injured individuals with spinal lesions at or above the mid-thoracic spinal cord level. It is a condition that remains poorly recognised outside of spinal cord injury centres, which may result i...

journal_title：Expert opinion on pharmacotherapy

authors： Khastgir J,Drake MJ,Abrams P

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION:Glaucoma is the second leading cause of blindness globally, representing a significant public health concern. More than 60 million people are affected by glaucoma worldwide; as this population ages, the number is expected to increase. Glaucoma is a collection of heterogeneous diseases sharing common clinic...

journal_title：Expert opinion on pharmacotherapy

authors： Konstas AG,Quaranta L,Realini T

更新日期：2012-04-01 00:00:00

abstract：:Elevated blood pressure levels are highly prevalent and are a major reason for cardiovascular events and thus place a significant financial burden on healthcare systems worldwide. Guidelines recommend five first-line anti-hypertensive drug classes, but compelling indications may indicate favoring one drug class over a...

journal_title：Expert opinion on pharmacotherapy

authors： Bramlage P,Durand-Zaleski I,Desai N,Pirk O,Hacker C

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:The global epidemic of diabetes has led to an epidemic of diabetes complications. Diabetic neuropathy is the most common microvascular complication, of which diabetic peripheral neuropathy (DPN) and autonomic neuropathy (AN) are the most prevalent, affecting ~50% of patients. DPN results in pain with a poo...

journal_title：Expert opinion on pharmacotherapy

authors： Azmi S,Alam U,Burgess J,Malik RA

更新日期：2021-01-01 00:00:00

abstract：:HIV infection has a complex relationship with poverty, but affects both the rich and poor. HIV/AIDS represents the deadliest emergency and the greatest social, economic and health crisis of modern times. The HIV pandemic affects developed and developing countries differently, with up to 95% of new HIV infections now o...

journal_title：Expert opinion on pharmacotherapy

authors： Muniyandi M,Ramachandran R,Balasubramanian R

更新日期：2006-12-01 00:00:00

abstract：:Interstitial cystitis is a clinical condition occurring predominantly in women characterised by irritative voiding symptoms in the form of urinary frequency, urgency and pain. Patient symptoms have the potential to significantly affect quality of life, posing a challenge to some to perform activities of daily living. ...

journal_title：Expert opinion on pharmacotherapy

authors： Lukban JC

更新日期：2003-11-01 00:00:00

abstract：INTRODUCTION:Generalized anxiety disorder (GAD) is a chronic, relapsing, debilitating disorder, associated with markedly impaired social and occupational functioning. Pharmacological treatment is considered standard care and several drug classes are now FDA approved for the treatment of GAD. While there are clear data ...

journal_title：Expert opinion on pharmacotherapy

authors： Reinhold JA,Mandos LA,Rickels K,Lohoff FW

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:Advances in acute lymphocytic leukemia (ALL) therapy has led to long-term survival rates in children. However, only 30%-40% of adults achieve long-term disease-free survival. After relapse, the outcome of salvage chemotherapy is very disappointing with less than 10% of long survival. Novel agents are there...

journal_title：Expert opinion on pharmacotherapy

authors： Thomas X,Le Jeune C

更新日期：2016-12-01 00:00:00

abstract：INTRODUCTION:The disturbing, foul-smelling discharge of bacterial vaginosis (BV) is a nuisance to women. Treatment possibilities for BV are limited and only achieve complete cure in 65 to 85% of cases. In most women, the condition relapses within weeks to months after treatment. AREAS COVERED:In search of new therapeu...

journal_title：Expert opinion on pharmacotherapy

authors： Donders GG,Zodzika J,Rezeberga D

更新日期：2014-04-01 00:00:00