Antral nodularity identifies children infected with Helicobacter pylori with higher grades of gastric inflammation.

Abstract:

BACKGROUND:The endoscopic pattern of antral nodularity is a peculiar finding in children with Helicobacter pylori infection. The aim of this study was to determine whether this finding is related to more severe gastritis. METHODS:One hundred seventy-four consecutive children (median age 8.7 years) referred for gastroscopy were studied. Biopsy specimens from the antrum and body of the stomach were taken to assess H pylori status, gastritis score, and lymphoid follicles. Clinical diagnosis, major symptoms and endoscopic findings were recorded. RESULTS:Eighty-four (48%) children (median age 10.5 years) had evidence of H pylori infection. The endoscopic pattern of antral nodularity was found only in children infected with H pylori (34/84, 40.5% vs. 0/90, 0%, p < 0.0001% 100% specificity, 40.5% sensitivity). Among all children infected with H pylori, the gastritis score was higher (p < 0.0001) in those with antral nodularity (n = 34) than in those without (n = 50). Completely normal gastric mucosal histology was never found in children infected with H pylori with antral nodularity. The presence and number of lymphoid follicles was strongly related to the finding of antral nodularity (p < 0.01). CONCLUSIONS:The endoscopic pattern of antral nodularity identifies children with H pylori infection, severe gastritis, and increased lymphoid follicles.

journal_name

Gastrointest Endosc

authors

Luzza F,Pensabene L,Imeneo M,Mancuso M,Contaldo A,Giancotti L,La Vecchia AM,Costa MC,Strisciuglio P,Docimo C,Pallone F,Guandalini S

doi

10.1067/mge.2001.111043

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

60-4

issue

1

eissn

0016-5107

issn

1097-6779

pii

S0016-5107(01)96162-0

journal_volume

53

pub_type

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