Apoptosis occurs after cerebral contusions in humans.

Abstract:

OBJECTIVE:Animal model systems have shown that head trauma can induce cell death in regions of the brain away from the site of the impact via a process of apoptosis. We sought to determine whether there was evidence of cellular apoptosis in clinically collected materials from human head trauma patients, as well as to attempt to determine the pathway by which it may occur. METHODS:Thirty-one sequential specimens of brain tissue excised during emergency craniotomy for evacuation of cerebral contusions with mass effect were examined. Non-necrotic pericontusional tissues were detected in 11 samples. These were examined for the presence of apoptotic cells by the terminal deoxynucleotide transferase-mediated nick end labeling method as well as by immunohistochemistry to detect possible expression of the apoptosis-related genes p53, bcl-2, and bax. RESULTS:Bax expression was detected in all patients, whereas bcl-2 expression was noted in six patients. Terminal deoxynucleotide transferase-mediated nick end labeling-positive cells were noted in eight patients. One instance of p53-positive immunostaining was observed. Patients with bcl-2 expression had a better survival rate than patients in whom no bcl-2 expression was noted (P = 0.01). CONCLUSION:Although necrosis seemed to be the main finding in cerebral contusions, these results support the hypothesis that apoptosis does occur in patients after traumatic brain injury, and this may contribute to the secondary injury processes that are seen with head injury. Patients in whom anti-apoptotic bcl-2 is induced seem to have a better prognosis. This may have important clinical significance in the development of bcl-2 homologs or bax inhibitors to prevent apoptosis.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Ng I,Yeo TT,Tang WY,Soong R,Ng PY,Smith DR

doi

10.1097/00006123-200004000-00034

keywords:

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

949-56

issue

4

eissn

0148-396X

issn

1524-4040

journal_volume

46

pub_type

杂志文章
  • Stereotactic radiosurgery in the treatment of metastatic disease to the brain.

    abstract:OBJECTIVE:In recent years, stereotactic radiosurgery has been growing in popularity as a treatment modality for metastatic disease to the brain. The technique has advantages of reduced cost and low morbidity compared with open surgical treatment. Furthermore, it avoids the potential cognitive side effects of fractionat...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200008000-00003

    authors: Chen JC,Petrovich Z,O'Day S,Morton D,Essner R,Giannotta SL,Yu C,Apuzzo ML

    更新日期:2000-08-01 00:00:00

  • Microendoscopic lumbar discectomy: technical note.

    abstract:OBJECTIVE:The microendoscopic discectomy (MED) technique was initially developed in 1997 to treat herniated lumbar disc disease. Since then, thousands of cases have been successfully performed at more than 500 institutions. This article discusses the technical aspects of this procedure and presents a consecutive case s...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章

    doi:

    authors: Perez-Cruet MJ,Foley KT,Isaacs RE,Rice-Wyllie L,Wellington R,Smith MM,Fessler RG

    更新日期:2002-11-01 00:00:00

  • Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells.

    abstract:OBJECTIVE:Adenomas of the pituitary gland are among the most common types of tumors of the adult brain. Although adenomas are histologically benign, they may be associated with significant morbidity and mortality, mostly because of their invasive growth pattern and hormone hypersecretion. Current medical therapies are ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000325874.82999.75

    authors: Vender JR,Laird MD,Dhandapani KM

    更新日期:2008-05-01 00:00:00

  • Brachial plexus compression caused by recurrent clavicular nonunion and space-occupying pseudoarthrosis: definitive reconstruction using free vascularized bone flap-a series of eight cases.

    abstract:OBJECTIVE:In rare cases, space-occupying pseudoarthrotic clavicular nonunion causes symptomatic brachial plexus compression. The surgical treatment of clavicular pseudoarthrosis has been extensively reported in the literature. This article reports our experience of a definitive treatment strategy using free vascularize...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000326036.54714.17

    authors: Krishnan KG,Mucha D,Gupta R,Schackert G

    更新日期:2008-05-01 00:00:00

  • Hemorrhage into a spinal ependymoma after peridural anesthesia.

    abstract::The authors present a case of the accidental puncture of a spinal ependymoma causing bleeding and an increase in the preexisting neurological deficits. ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198505000-00016

    authors: Antoniadis G,Richter HP,Schachenmayr W

    更新日期:1985-05-01 00:00:00

  • Fate of clots in patients with subarachnoid hemorrhage after different surgical treatment modality: a comparison between surgical clipping and Guglielmi detachable coil embolization.

    abstract:BACKGROUND:Subarachnoid clot is important in the development of delayed vasospasm after subarachnoid hemorrhage (SAH). OBJECTIVE:To compare the clearance of subarachnoid clot and the incidence of symptomatic vasospasm in surgical clipping and embolization with Guglielmi detachable coils for aneurysmal SAH. METHODS:Th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318208f1ba

    authors: Shirao S,Yoneda H,Ishihara H,Harada K,Ueda K,Sano Y,Kudomi S,Hayashi Y,Shigeeda T,Nakano K,Nomura S,Fujii M,Kato S,Suzuki M

    更新日期:2011-04-01 00:00:00

  • Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:We examined the incidence of perioperative fever and its relationship to outcome among patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial. METHODS:One thousand patients with initial World Federation of Neurological Surgeons grades of I to III undergoing clipping of intracranial an...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1227/01.NEU.0000341903.11527.2F

    authors: Todd MM,Hindman BJ,Clarke WR,Torner JC,Weeks JB,Bayman EO,Shi Q,Spofford CM,IHAST Investigators.

    更新日期:2009-05-01 00:00:00

  • Percutaneous placement of an external drain of the cisterna magna using interventional magnetic resonance imaging in a patient with a persistent cerebrospinal fluid fistula: technical case report.

    abstract:OBJECTIVE:Cerebrospinal fluid diversion from the cisterna magna has been described previously but has largely been abandoned because of high complication rates and anatomic constraints. Situations still remain in which this may be the best or only alternative. We describe the use of interventional magnetic resonance im...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000312716.08933.C5

    authors: Walker JB,Harkey HL,Buciuc R

    更新日期:2008-08-01 00:00:00

  • Posterior-only approach for en bloc sacrectomy: clinical outcomes in 36 consecutive patients.

    abstract:BACKGROUND:En bloc resection of primary sacral tumors has a demonstrated survival benefit. Total and high sacral amputations are traditionally performed by using a staged anterior and subsequent posterior approach. However, we have found that en bloc resection and biomechanical reconstruction of the spinal column is po...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.1227/NEU.0b013e31825d01d4

    authors: Clarke MJ,Dasenbrock H,Bydon A,Sciubba DM,McGirt MJ,Hsieh PC,Yassari R,Gokaslan ZL,Wolinsky JP

    更新日期:2012-08-01 00:00:00

  • Direct surgery of carotid cavernous fistulae and dural arteriovenous malformations of the cavernous sinus.

    abstract:OBJECTIVE:To save the patency of the internal carotid artery (ICA) during the treatment of carotid cavernous fistulae or cavernous sinus dural arteriovenous malformations, direct surgery of the cavernous sinus after failure of endovascular treatment was attempted in this study. METHODS:A total of 78 patients with caro...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199710000-00006

    authors: Tu YK,Liu HM,Hu SC

    更新日期:1997-10-01 00:00:00

  • Mesenchymal stem cell and gene therapies for spinal fusion.

    abstract::THE IDEAL GRAFT material to promote spinal fusion should possess osteoconductive, osteoinductive, and osteogenic properties. Although autogenous bone graft has all three qualities and is the standard for comparison, research has focused on finding alternatives that have similar efficacy but not the morbidities associa...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.NEU.0000324990.04818.13

    authors: Gottfried ON,Dailey AT

    更新日期:2008-09-01 00:00:00

  • Multifocal Intradural Extramedullary Pilocytic Astrocytomas of the Spinal Cord: A Case Report and Review of the Literature.

    abstract:Background and importance:Pilocytic astrocytoma (PA) is among the most common of the central nervous system gliomas in the pediatric population; however, it is uncommon in adults. PAs of the spinal cord in adults are even rarer, with only a few cases found in the literature. We report here the first case in the literat...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1093/neuros/nyw029

    authors: Basheer A,Rammo R,Kalkanis S,Felicella MM,Chedid M

    更新日期:2017-02-01 00:00:00

  • Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma: initial experience in 51 patients.

    abstract:OBJECTIVE:We report the safety and feasibility of using convection-enhanced delivery to administer Cotara (Peregrine Pharmaceuticals, Inc., Tustin, CA), a novel radioimmunotherapeutic agent, to patients with malignant glioma. METHODS:Between April 1998 and November 2002, 51 patients with histologically confirmed malig...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/01.neu.0000159649.71890.30

    authors: Patel SJ,Shapiro WR,Laske DW,Jensen RL,Asher AL,Wessels BW,Carpenter SP,Shan JS

    更新日期:2005-06-01 00:00:00

  • Accuracy of postoperative computed tomography and magnetic resonance image fusion for assessing deep brain stimulation electrodes.

    abstract:BACKGROUND:Knowledge of the anatomic location of the deep brain stimulation (DBS) electrode in the brain is essential in quality control and judicious selection of stimulation parameters. Postoperative computed tomography (CT) imaging coregistered with preoperative magnetic resonance imaging (MRI) is commonly used to d...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318218c7ae

    authors: Thani NB,Bala A,Swann GB,Lind CR

    更新日期:2011-07-01 00:00:00

  • Air embolism during trans-sphenoidal pituitary operations.

    abstract::Doppler ultrasonic cardiac monitoring of patients undergoing trans-sphenoidal pituitary operations in the semisitting position has revealed the occurrence of venous air embolism in 3 of 31 consecutive cases. One such case is presented. Air may be drawn into the venous system whenever a gradient exists between the site...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-197801000-00008

    authors: Newfield P,Albin MS,Chestnut JS,Maroon J

    更新日期:1978-01-01 00:00:00

  • A new type of prehensile suction device.

    abstract::The authors describe a new suction device with prehensile properties that has proved itself particularly useful in the removal of certain types of tumor, especially extramedullary. ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198710000-00031

    authors: Cantore G,Ciappetta P

    更新日期:1987-10-01 00:00:00

  • Sarcoidosis presenting as an isolated intramedullary tumor.

    abstract::We report a case of isolated intramedullary sarcoidosis. The patient developed progressive signs that indicated a spinal tumor, which were investigated with contrast-enhanced magnetic resonance imaging scans. Magnetic resonance imaging clearly revealed an intramedullary lesion, but the diagnosis of sarcoidosis was mad...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199108000-00020

    authors: Levivier M,Brotchi J,Balériaux D,Pirotte B,Flament-Durand J

    更新日期:1991-08-01 00:00:00

  • Prophylactic hypervolemia without calcium channel blockers in early aneurysm surgery.

    abstract::Delayed ischemic neurological deficit (DIND) remains a major unsolved problem in the management of aneurysmal subarachnoid hemorrhage (SAH). For many years, the complications reported with acute aneurysm surgery caused surgeons to operate late after SAH. In a 42-month-period, we managed 146 patients with aneurysm and/...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199201000-00003

    authors: Medlock MD,Dulebohn SC,Elwood PW

    更新日期:1992-01-01 00:00:00

  • Cranial surgery in ancient Peru.

    abstract::Trephination is the oldest known surgical technique. Peru has been recognized as a major source of ancient trephined skulls, many of which date back 2300 years. This presentation reviews from a neurosurgical perspective many of the archaeological studies performed on these skulls. Comparative osteology has shown that ...

    journal_title:Neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.1227/00006123-198810000-00001

    authors: Rifkinson-Mann S

    更新日期:1988-10-01 00:00:00

  • Endoscopic third ventriculostomy in pediatric patients: the Canadian experience.

    abstract:OBJECTIVE:Reports from relatively small series of pediatric patients predominantly from single centers have hampered accurate analysis of outcome from endoscopic third ventriculostomy. We combined patients from nine pediatric neurosurgery centers across Canada to obtain a better estimate of outcome and identify factors...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/01.NEU.0000255420.78431.E7

    authors: Drake JM,Canadian Pediatric Neurosurgery Study Group.

    更新日期:2007-05-01 00:00:00

  • Cerebral autoregulation among patients with symptoms of hydrocephalus.

    abstract:OBJECTIVE:To study the relationship between the resistance to cerebrospinal fluid (CSF) outflow and cerebral autoregulation. METHODS:We examined 35 patients who presented with ventricular dilation and clinical symptoms of communicating hydrocephalus. For all of these patients, CSF compensatory reserve was investigated...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200203000-00018

    authors: Czosnyka ZH,Czosnyka M,Whitfield PC,Donovan T,Pickard JD

    更新日期:2002-03-01 00:00:00

  • Occipital sinus pericranii superseding both jugular veins: description of two rare pediatric cases.

    abstract:BACKGROUND AND IMPORTANCE:The extracranial venous drainage of the brain is provided mainly by the jugular veins with the variable participation of extrajugular pathways. CLINICAL PRESENTATION:Two cases of occipital sinus pericranii (SP) were observed. A 6-year-old girl presented with a progressively enlarging occipita...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e31828baab4

    authors: Frassanito P,Massimi L,Tamburrini G,Caldarelli M,Pedicelli A,Di Rocco C

    更新日期:2013-06-01 00:00:00

  • Linear accelerator radiosurgery of cerebral arteriovenous malformations: an update.

    abstract::One hundred eighty patients affected by cerebral arteriovenous malformations (AVMs) underwent radiosurgical treatment in our department. One hundred fifty-three patients have been treated with complete irradiation of the entire AVM nidus. In 27 patients (with large and/or three-dimensional irregular target volumes), o...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Colombo F,Pozza F,Chierego G,Casentini L,De Luca G,Francescon P

    更新日期:1994-01-01 00:00:00

  • Quality of life after brainstem cavernoma surgery in 71 patients.

    abstract:BACKGROUND:Symptomatic patients with a brainstem cavernoma are treated surgically with increasing frequency. Generally, the patient's benefit from this difficult surgical intervention is quantified by the assessment of neurological symptoms. OBJECTIVE:To document the beneficial effect of surgery in a larger patient po...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e31821d31b7

    authors: Dukatz T,Sarnthein J,Sitter H,Bozinov O,Benes L,Sure U,Bertalanffy H

    更新日期:2011-09-01 00:00:00

  • Idiopathic brachial neuritis.

    abstract::Parsonage-Turner syndrome (PTS) is a rare syndrome of unknown cause, affecting mainly the lower motor neurons of the brachial plexus. The brachial plexus is a group of nerves that conduct signals from the spine to the shoulder, arm, and hand. PTS is usually characterized by the sudden onset of severe 1-sided shoulder ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.NEU.0000345355.59438.D1

    authors: Sumner AJ

    更新日期:2009-10-01 00:00:00

  • Evaluation of hydrocephalic periventricular radiolucency by dynamic computed tomography and xenon-computed tomography.

    abstract:OBJECTIVE:A common finding of computed tomography in a case of normal-pressure hydrocephalus (NPH) is periventricular radiolucency (PVL). We analyzed PVL for patients with hydrocephalus, using dynamic computed tomographic and xenon-computed tomographic techniques to differentiate NPH from similar diseases. METHODS:Dyn...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199610000-00023

    authors: Nakano H,Bandoh K,Miyaoka M,Sato K

    更新日期:1996-10-01 00:00:00

  • Image-Guided, Linac-Based, Surgical Cavity-Hypofractionated Stereotactic Radiotherapy in 5 Daily Fractions for Brain Metastases.

    abstract:BACKGROUND:Cavity stereotactic radiotherapy has emerged as a standard option following resection of brain metastases. However, the optimal approach with either single-fraction or hypofractionated stereotactic radiotherapy (HSRT) remains a significant question. OBJECTIVE:To report outcomes for 5-fraction HSRT to the su...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyz162

    authors: Soliman H,Myrehaug S,Tseng CL,Ruschin M,Hashmi A,Mainprize T,Spears J,Das S,Yang V,da Costa L,Maralani P,Heyn C,Atenafu EG,Sahgal A

    更新日期:2019-11-01 00:00:00

  • Stereotactic minimally invasive tubular retractor system for deep brain lesions.

    abstract:OBJECTIVE:Deep-seated supratentorial intraparenchymal and intraventricular brain lesions can be difficult to access without causing significant trauma to the overlying cortex and intervening white matter tracts. Traditional brain retractors use multiple blades, which do not exert pressure in an equally distributed fash...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000334741.61745.72

    authors: Greenfield JP,Cobb WS,Tsouris AJ,Schwartz TH

    更新日期:2008-10-01 00:00:00

  • Angioscopy-assisted aneurysm clipping.

    abstract:OBJECTIVE:To test the concept that endovascular angioscopy can assist surgical intracranial aneurysm clipping by providing an endoluminal view of the aneurysm-parent vessel complex. METHODS:A carotid bifurcation aneurysm was surgically created in a dog at the lingual artery origin. A balloon catheter was inflated prox...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199909000-00032

    authors: Lanzino G,Miskolczi L,Guterman LR,Hopkins LN

    更新日期:1999-09-01 00:00:00

  • Trochlear nerve schwannomas occurring in patients without neurofibromatosis: case report and review of the literature.

    abstract:OBJECTIVE AND IMPORTANCE:Despite their predilection for sensory nerves, intracranial schwannomas have been reported in a number of mixed and purely motor cranial nerves, especially in association with Type 2 neurofibromatosis. We report the rare occurrence of a trochlear nerve schwannoma in a patient without neurofibro...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199707000-00050

    authors: Santoreneos S,Hanieh A,Jorgensen RE

    更新日期:1997-07-01 00:00:00