Abstract:
OBJECTIVE:Animal model systems have shown that head trauma can induce cell death in regions of the brain away from the site of the impact via a process of apoptosis. We sought to determine whether there was evidence of cellular apoptosis in clinically collected materials from human head trauma patients, as well as to attempt to determine the pathway by which it may occur. METHODS:Thirty-one sequential specimens of brain tissue excised during emergency craniotomy for evacuation of cerebral contusions with mass effect were examined. Non-necrotic pericontusional tissues were detected in 11 samples. These were examined for the presence of apoptotic cells by the terminal deoxynucleotide transferase-mediated nick end labeling method as well as by immunohistochemistry to detect possible expression of the apoptosis-related genes p53, bcl-2, and bax. RESULTS:Bax expression was detected in all patients, whereas bcl-2 expression was noted in six patients. Terminal deoxynucleotide transferase-mediated nick end labeling-positive cells were noted in eight patients. One instance of p53-positive immunostaining was observed. Patients with bcl-2 expression had a better survival rate than patients in whom no bcl-2 expression was noted (P = 0.01). CONCLUSION:Although necrosis seemed to be the main finding in cerebral contusions, these results support the hypothesis that apoptosis does occur in patients after traumatic brain injury, and this may contribute to the secondary injury processes that are seen with head injury. Patients in whom anti-apoptotic bcl-2 is induced seem to have a better prognosis. This may have important clinical significance in the development of bcl-2 homologs or bax inhibitors to prevent apoptosis.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Ng I,Yeo TT,Tang WY,Soong R,Ng PY,Smith DRdoi
10.1097/00006123-200004000-00034keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
949-56issue
4eissn
0148-396Xissn
1524-4040journal_volume
46pub_type
杂志文章相关文献
NEUROSURGERY文献大全abstract:OBJECTIVE:In recent years, stereotactic radiosurgery has been growing in popularity as a treatment modality for metastatic disease to the brain. The technique has advantages of reduced cost and low morbidity compared with open surgical treatment. Furthermore, it avoids the potential cognitive side effects of fractionat...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200008000-00003
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:The microendoscopic discectomy (MED) technique was initially developed in 1997 to treat herniated lumbar disc disease. Since then, thousands of cases have been successfully performed at more than 500 institutions. This article discusses the technical aspects of this procedure and presents a consecutive case s...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:Adenomas of the pituitary gland are among the most common types of tumors of the adult brain. Although adenomas are histologically benign, they may be associated with significant morbidity and mortality, mostly because of their invasive growth pattern and hormone hypersecretion. Current medical therapies are ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000325874.82999.75
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:In rare cases, space-occupying pseudoarthrotic clavicular nonunion causes symptomatic brachial plexus compression. The surgical treatment of clavicular pseudoarthrosis has been extensively reported in the literature. This article reports our experience of a definitive treatment strategy using free vascularize...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000326036.54714.17
更新日期:2008-05-01 00:00:00
abstract::The authors present a case of the accidental puncture of a spinal ependymoma causing bleeding and an increase in the preexisting neurological deficits. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198505000-00016
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:Subarachnoid clot is important in the development of delayed vasospasm after subarachnoid hemorrhage (SAH). OBJECTIVE:To compare the clearance of subarachnoid clot and the incidence of symptomatic vasospasm in surgical clipping and embolization with Guglielmi detachable coils for aneurysmal SAH. METHODS:Th...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318208f1ba
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:We examined the incidence of perioperative fever and its relationship to outcome among patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial. METHODS:One thousand patients with initial World Federation of Neurological Surgeons grades of I to III undergoing clipping of intracranial an...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1227/01.NEU.0000341903.11527.2F
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Cerebrospinal fluid diversion from the cisterna magna has been described previously but has largely been abandoned because of high complication rates and anatomic constraints. Situations still remain in which this may be the best or only alternative. We describe the use of interventional magnetic resonance im...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.NEU.0000312716.08933.C5
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:En bloc resection of primary sacral tumors has a demonstrated survival benefit. Total and high sacral amputations are traditionally performed by using a staged anterior and subsequent posterior approach. However, we have found that en bloc resection and biomechanical reconstruction of the spinal column is po...
journal_title:Neurosurgery
pub_type: 临床试验,杂志文章
doi:10.1227/NEU.0b013e31825d01d4
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To save the patency of the internal carotid artery (ICA) during the treatment of carotid cavernous fistulae or cavernous sinus dural arteriovenous malformations, direct surgery of the cavernous sinus after failure of endovascular treatment was attempted in this study. METHODS:A total of 78 patients with caro...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199710000-00006
更新日期:1997-10-01 00:00:00
abstract::THE IDEAL GRAFT material to promote spinal fusion should possess osteoconductive, osteoinductive, and osteogenic properties. Although autogenous bone graft has all three qualities and is the standard for comparison, research has focused on finding alternatives that have similar efficacy but not the morbidities associa...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.NEU.0000324990.04818.13
更新日期:2008-09-01 00:00:00
abstract:Background and importance:Pilocytic astrocytoma (PA) is among the most common of the central nervous system gliomas in the pediatric population; however, it is uncommon in adults. PAs of the spinal cord in adults are even rarer, with only a few cases found in the literature. We report here the first case in the literat...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1093/neuros/nyw029
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:We report the safety and feasibility of using convection-enhanced delivery to administer Cotara (Peregrine Pharmaceuticals, Inc., Tustin, CA), a novel radioimmunotherapeutic agent, to patients with malignant glioma. METHODS:Between April 1998 and November 2002, 51 patients with histologically confirmed malig...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.neu.0000159649.71890.30
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Knowledge of the anatomic location of the deep brain stimulation (DBS) electrode in the brain is essential in quality control and judicious selection of stimulation parameters. Postoperative computed tomography (CT) imaging coregistered with preoperative magnetic resonance imaging (MRI) is commonly used to d...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e318218c7ae
更新日期:2011-07-01 00:00:00
abstract::Doppler ultrasonic cardiac monitoring of patients undergoing trans-sphenoidal pituitary operations in the semisitting position has revealed the occurrence of venous air embolism in 3 of 31 consecutive cases. One such case is presented. Air may be drawn into the venous system whenever a gradient exists between the site...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-197801000-00008
更新日期:1978-01-01 00:00:00
abstract::The authors describe a new suction device with prehensile properties that has proved itself particularly useful in the removal of certain types of tumor, especially extramedullary. ...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-198710000-00031
更新日期:1987-10-01 00:00:00
abstract::We report a case of isolated intramedullary sarcoidosis. The patient developed progressive signs that indicated a spinal tumor, which were investigated with contrast-enhanced magnetic resonance imaging scans. Magnetic resonance imaging clearly revealed an intramedullary lesion, but the diagnosis of sarcoidosis was mad...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199108000-00020
更新日期:1991-08-01 00:00:00
abstract::Delayed ischemic neurological deficit (DIND) remains a major unsolved problem in the management of aneurysmal subarachnoid hemorrhage (SAH). For many years, the complications reported with acute aneurysm surgery caused surgeons to operate late after SAH. In a 42-month-period, we managed 146 patients with aneurysm and/...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/00006123-199201000-00003
更新日期:1992-01-01 00:00:00
abstract::Trephination is the oldest known surgical technique. Peru has been recognized as a major source of ancient trephined skulls, many of which date back 2300 years. This presentation reviews from a neurosurgical perspective many of the archaeological studies performed on these skulls. Comparative osteology has shown that ...
journal_title:Neurosurgery
pub_type: 历史文章,杂志文章
doi:10.1227/00006123-198810000-00001
更新日期:1988-10-01 00:00:00
abstract:OBJECTIVE:Reports from relatively small series of pediatric patients predominantly from single centers have hampered accurate analysis of outcome from endoscopic third ventriculostomy. We combined patients from nine pediatric neurosurgery centers across Canada to obtain a better estimate of outcome and identify factors...
journal_title:Neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1227/01.NEU.0000255420.78431.E7
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To study the relationship between the resistance to cerebrospinal fluid (CSF) outflow and cerebral autoregulation. METHODS:We examined 35 patients who presented with ventricular dilation and clinical symptoms of communicating hydrocephalus. For all of these patients, CSF compensatory reserve was investigated...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-200203000-00018
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND AND IMPORTANCE:The extracranial venous drainage of the brain is provided mainly by the jugular veins with the variable participation of extrajugular pathways. CLINICAL PRESENTATION:Two cases of occipital sinus pericranii (SP) were observed. A 6-year-old girl presented with a progressively enlarging occipita...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31828baab4
更新日期:2013-06-01 00:00:00
abstract::One hundred eighty patients affected by cerebral arteriovenous malformations (AVMs) underwent radiosurgical treatment in our department. One hundred fifty-three patients have been treated with complete irradiation of the entire AVM nidus. In 27 patients (with large and/or three-dimensional irregular target volumes), o...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Symptomatic patients with a brainstem cavernoma are treated surgically with increasing frequency. Generally, the patient's benefit from this difficult surgical intervention is quantified by the assessment of neurological symptoms. OBJECTIVE:To document the beneficial effect of surgery in a larger patient po...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/NEU.0b013e31821d31b7
更新日期:2011-09-01 00:00:00
abstract::Parsonage-Turner syndrome (PTS) is a rare syndrome of unknown cause, affecting mainly the lower motor neurons of the brachial plexus. The brachial plexus is a group of nerves that conduct signals from the spine to the shoulder, arm, and hand. PTS is usually characterized by the sudden onset of severe 1-sided shoulder ...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1227/01.NEU.0000345355.59438.D1
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:A common finding of computed tomography in a case of normal-pressure hydrocephalus (NPH) is periventricular radiolucency (PVL). We analyzed PVL for patients with hydrocephalus, using dynamic computed tomographic and xenon-computed tomographic techniques to differentiate NPH from similar diseases. METHODS:Dyn...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199610000-00023
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Cavity stereotactic radiotherapy has emerged as a standard option following resection of brain metastases. However, the optimal approach with either single-fraction or hypofractionated stereotactic radiotherapy (HSRT) remains a significant question. OBJECTIVE:To report outcomes for 5-fraction HSRT to the su...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1093/neuros/nyz162
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Deep-seated supratentorial intraparenchymal and intraventricular brain lesions can be difficult to access without causing significant trauma to the overlying cortex and intervening white matter tracts. Traditional brain retractors use multiple blades, which do not exert pressure in an equally distributed fash...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1227/01.neu.0000334741.61745.72
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:To test the concept that endovascular angioscopy can assist surgical intracranial aneurysm clipping by providing an endoluminal view of the aneurysm-parent vessel complex. METHODS:A carotid bifurcation aneurysm was surgically created in a dog at the lingual artery origin. A balloon catheter was inflated prox...
journal_title:Neurosurgery
pub_type: 杂志文章
doi:10.1097/00006123-199909000-00032
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Despite their predilection for sensory nerves, intracranial schwannomas have been reported in a number of mixed and purely motor cranial nerves, especially in association with Type 2 neurofibromatosis. We report the rare occurrence of a trochlear nerve schwannoma in a patient without neurofibro...
journal_title:Neurosurgery
pub_type: 杂志文章,评审
doi:10.1097/00006123-199707000-00050
更新日期:1997-07-01 00:00:00