The relationship between fMRI activation and cerebral atrophy: comparison of normal aging and alzheimer disease.

Abstract:

:Functional MRI has recently been used to examine activation associated with aging and dementia, yet little is known regarding the effect of cerebral atrophy on fMRI signal. The purpose of this study was to examine the relationship between measures of global and regionally specific atrophy and fMRI activation in normal aging and in Alzheimer disease (AD). Two groups of subjects were studied with echoplanar imaging and quantitative structural volumetry: healthy controls spanning a broad age and atrophy range (n = 16) and patients with mild AD (n = 8). Results from a semantic task previously found to activate left inferior frontal (LIFG) and left superior temporal (LSTG) gyri were analyzed. The correlations between clusters of activation in the LIFG and LSTG and measures of local atrophy in the LIFG and LSTG regions were evaluated. For control subjects, there was no significant correlation between activation and regional or total brain atrophy (for LIFG r = -0.03, NS; for LSTG r = 0.20, NS). In contrast, for AD patients, there was a significant positive correlation between atrophy and activation in LIFG (r = 0.70, P = 0.05) but not LSTG (r = 0.00, NS). These results suggest that activation of language regions and atrophy within those regions may be independent among healthy adults spanning a broad age and atrophy range. However, in AD, a relationship exists in the LIFG that may reflect compensatory recruitment of cortical units or disease-specific changes in the hemodynamic response.

journal_name

Neuroimage

journal_title

NeuroImage

authors

Johnson SC,Saykin AJ,Baxter LC,Flashman LA,Santulli RB,McAllister TW,Mamourian AC

doi

10.1006/nimg.1999.0530

keywords:

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

179-87

issue

3

eissn

1053-8119

issn

1095-9572

pii

S1053-8119(99)90530-X

journal_volume

11

pub_type

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