Abstract：
:The surface electrocardiogram can be simply described as the P, QRS, and T (and U) waves, together with PR and ST segments. However, it is actually the summation of the action potential from the sinoatrial node, the atria, the atrioventricular node, the His-Purkinje system, and the ventricles. Although the action potential can be divided grossly into 5 phases, its characteristics vary in different cardiac tissue. This is because the action potential is the end-result of multiple ion channels, pumps, and exchangers opening and closing in concert, and the properties and distribution of these components can be different from one tissue to another. The ion channels can be activated by changes in the membrane voltage and specific ligands, and can be modulated by factors such as neurotransmitters (e.g., through the G-protein system), the G-proteins directly, or other ions. Only in the last 10 years have investigators been able to use molecular biology techniques to peek into the primary structure of ion channels and to develop more workable models of the channel functions. The primary structure and the putative secondary structure of the ion channels show resemblance among the groups, suggesting that, except for IsK, the development of ion channels started with IK1 and IK(ACh), followed by Ito and IK, and then by INa and ICa. However, limitations still exist in our knowledge of the ion channels and hence of the action potential. This is demonstrated by the lack of effective pharmacologic treatment of cardiac arrhythmias to this date. It is to be hoped that advances in cell electrophysiology, genetic engineering, and molecular imaging techniques will soon end the dark days of antiarrhythmic therapy.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Shih HTsubject
Has Abstractpub_date
1994-01-01 00:00:00pages
30-41issue
1eissn
0730-2347issn
1526-6702journal_volume
21pub_type
杂志文章,评审abstract：:Severe diffuse obstruction of the coronary arteries was diagnosed in an 18-month-old girl who presented with signs and symptoms of severe congestive cardiomyopathy. Most reported cases of myocardial infarction in neonates or infants have been secondary to obstruction of a single major coronary artery owing to thrombos...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1987-12-01 00:00:00
abstract：:Skeletal muscle ventricles are constructed from canine latissimus dorsi muscle. These skeletal muscle ventricles can be placed subcutaneously on the chest wall or inside the chest cavity. Skeletal muscle ventricles are connected to the descending thoracic aorta and activated to pump blood as aortic diastolic counterpu...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Apical akinesis and dilation in the absence of obstructive coronary artery disease is a typical feature of stress-induced (takotsubo) cardiomyopathy, whereas apical hypertrophy is seen in apical-variant hypertrophic cardiomyopathy. We report the cases of 2 patients who presented with takotsubo cardiomyopathy and were ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3191
更新日期：2014-04-01 00:00:00
abstract：:A simple technique of controlling a bleeding aortic cannulation site employing autogenous tissue is described in which 3-0 Prolene suture is placed through the lateral pericardial tissue on both sides of the aortotomy closure in a horizontal mattress fashion. This technique is advantageous because of the availability ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：:A 14-month-old boy with a structurally normal heart presented with signs of cardiac tamponade caused by purulent pericarditis. During his hospital stay, mitral and tricuspid valve endocarditis developed, and a ventricular septal abscess expanded despite appropriate, prolonged antibiotic therapy for methicillin-resista...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3685
更新日期：2015-02-01 00:00:00
abstract：:A 60-year-old man with an acute inferior-wall myocardial infarction was noted, on arteriography, to have an occluded distal right coronary artery. The vessel was reopened with intravenous tissue plasminogen activator; during resolution of the clot, spasm was observed arteriographically but was successfully treated wit...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:Most commonly, coronary artery aneurysms are secondary to atherosclerosis, but cases have been reported in patients who have vasculitis or tissue disorders, and in patients who have undergone interventional procedures. However, over the past few years, an increasing number of cases of coronary artery aneurysms after d...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:Left ventricular hypertrophy in aortic stenosis is considered a compensatory response for the maintenance of systolic function but a risk factor for cardiac morbidity and death. We investigated the degree of left ventricular mass regression after implantation of the sutureless Medtronic 3f Enable Aortic Bioprosthesis....
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3943
更新日期：2015-04-01 00:00:00
abstract：:In selected patients, transcatheter closure of atrial septal defects with the AMPLATZER Septal Occluder has yielded excellent results. However, there is a slight risk of device embolization after deployment. We report the case of a 26-year-old woman in whom an embolized AMPLATZER device was retrieved percutaneously fr...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:This report describes the case of a 61-year-old woman who presented with dyspnea, aortic stenosis, and coronary artery disease-typical side effects of radiation therapy for Hodgkin lymphoma. A poor candidate for surgery, she underwent successful high-risk percutaneous coronary intervention and subsequent transcatheter...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-16-5806
更新日期：2016-08-01 00:00:00
abstract：:We present a case of aortic valve replacement combined with aortic root enlargement, performed on an achondroplastic dwarf with severe calcific aortic stenosis. There are no data about the incidence of valvular diseases in achondroplastic patients. To our knowledge, this is the 1st time that an aortic valve replacemen...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Approximately 20% to 30% of patients who undergo coronary arteriography for the evaluation of chest pain are found to have normal coronary arteries. These patients have a survival rate comparable to that of the normal population, yet they continue to complain of symptoms on extended follow-up, and about half of this g...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：1993-01-01 00:00:00
abstract：:Pseudoaneurysm of the mitral-aortic intervalvular fibrosa is a rare but serious sequela of endocarditis or valve replacement surgery. Because open-heart surgery is a high-risk treatment option, alternative methods are sought. We present the case of a 77-year-old man with a noninfected mechanical mitral valve whose pse...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-14-4156
更新日期：2015-06-01 00:00:00
abstract：:Both conventional Argon- and NdYAG-lasers in continuous wave or pulsed application and far ultraviolet laser radiation are able to cause a loss of substance of biologic tissue. The thermic and ablative effects of NdYAG-lasers and UV-Excimer lasers at the wavelengths of 193 nm (ArF) and 248 mm (KrF) on inconspicuous an...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:Influenza causes cardiac and pulmonary complications that can lead to death. Its effect on the conduction system, first described a century ago, has long been thought to be fairly benign. We report 2 cases of high-grade atrioventricular block associated with acute influenza infection. Both patients-a 50-year-old woman...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-18-6658
更新日期：2020-06-01 00:00:00
abstract：:Malignant metastases to the heart and pericardium, which occur far more often than do primary cardiac neoplasms, typically lead to fatal outcomes. The phyllodes tumor is a rare, predominantly benign fibroepithelial breast neoplasm with variable malignancy potential. Herein, we describe the case of a 35-year-old woman ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Assessing thromboembolic risk is crucial for proper management of patients with atrial fibrillation. Left atrial volume is a promising predictor of cardiac thrombosis. To determine whether left atrial volume can predict left atrial appendage thrombus in patients with atrial fibrillation, we conducted a prospective stu...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-17-6290
更新日期：2020-04-01 00:00:00
abstract：:We reviewed the clinical records of the 1st 144 consecutive patients in whom the Probe trade mark, a balloon-on-the-wire, was used for percutaneous transluminal coronary angioplasty at the Texas Heart Institute. The goal of our retrospective study was to establish the efficacy and safety of this new balloon catheter. ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:We report an interesting case of single right coronary artery arising from the right sinus of Valsalva and continuing distally as a rare anomalous left coronary artery. Over the 7-year course of our clinical follow-up, the right coronary artery manifested severe, progressive atherosclerotic disease in multiple sites, ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Ischemic mitral regurgitation, a complication of myocardial infarction, is associated with a poor prognosis and can result in postinfarction congestive heart failure. The preferred treatment of its chronic form is a matter of debate. Herein, we report the early and midterm results in 44 patients with chronic ischemic ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:Cobrahead deformity is a known (but uncommon) phenomenon associated with the left atrial disc of the Amplatzer or Occlutech Figulla septal occluder device during percutaneous transcatheter atrial septal defect closure. It has also been postulated that the right atrial disc of the Amplatzer septal occluder device might...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-14-4179
更新日期：2015-10-01 00:00:00
abstract：:During his work, an 18-year-old carpenter-in-training overbalanced and shot himself in the left median thorax with a nail gun. The patient was delivered to our thoracic surgery unit with a tentative diagnosis of penetrating lung trauma. An emergent computed tomogram showed a heart-penetrating nail injury. The patient ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3405
更新日期：2014-08-01 00:00:00
abstract：:We describe a technique of intravalvular implantation of a low-profile prosthesis that has been used in nine patients with mitral valve lesions. This technique preserves the anterior and posterior chordae and papillary mechanisms, which may decrease the incidence of postoperative left ventricular dysfunction that has ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1987-06-01 00:00:00
abstract：:We studied the structural and functional heart adaptations of 52 male triathletes compared with those of 22 active, nonathletic men, by 2-dimensional Doppler echocardiography. Left ventricular diastolic function was evaluated by recording transmitral flow velocities. To exclude the influences of preload, left atrial p...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:We report the case of a 65-year-old man with a 6-year history of hypertension who presented with dilated cardiomyopathy, a transient cerebrovascular event, paroxysmal sweating, and intractable hypertension. Coronary angiography revealed no abnormality, but diagnostic testing was pursued because of the severe sweating ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:A 49-year-old patient, referred with a diagnosis of right atrial myxoma, was found at surgery to have extensive cardiac metastases from a previously undetected cutaneous melanoma. In reviewing the literature, we found 5 other patients with a clinical diagnosis of melanoma metastatic to the heart, all of whom had a pre...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Minimally invasive cardiac surgery is rapidly gaining interest because of fast recovery, reduced morbidity, shorter hospital stay, lower costs, and better cosmetic results. Aortic valve surgery can be performed through a small (10- to 12-cm) transverse sternal incision, and femoro-femoral cannulation is used for cardi...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:In recent years, researchers have investigated the relationship between biological markers of inflammation and prognosis in patients who experience acute coronary syndromes; however, the association between plasma fibrinogen and coronary heart disease is still not clear. We studied the prognostic value of fibrinogen, ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:Aortoiliac occlusive disease is a frequently encountered occlusive arterial disease. Different surgical approaches to the infrarenal abdominal aorta have been reported. We retrospectively studied the postoperative outcomes of patients who were treated for aortoiliac occlusive disease via a retroperitoneal versus a tra...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:We describe our experience with the transseptal approach for mitral valve replacement, a technique that we applied especially in cases of 3rd and 4th operations wherein numerous adhesions made the usual left atrial approach difficult. We report 39 cases of mitral procedures in which we used 3 slightly different transs...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
