Immunity-Boosting Spices and the Novel Coronavirus.

abstract：:Alzheimer's disease (AD) is a significant health crisis, and current treatments provide only limited benefits to cognition at the cost of serious side effects. Recently, virtual screening techniques such as ligand-based virtual screening (LBVS) and structure-based virtual screening (SBVS) have emerged as powerful drug...

journal_title：ACS chemical neuroscience

authors： Miles JA,Ross BP

更新日期：2021-01-06 00:00:00

abstract：:Intra- and extraneuronal deposition of amyloid β (Aβ) peptides have been linked to Alzheimer's disease (AD). While both intra- and extraneuronal Aβ deposits affect neuronal cell viability, the molecular mechanism by which these Aβ structures, especially when intraneuronal, do so is still not entirely understood. This ...

journal_title：ACS chemical neuroscience

authors： Banerjee V,Oren O,Dagan B,Taube R,Engel S,Papo N

更新日期：2019-03-20 00:00:00

abstract：:Reversion of protein or peptide aggregation is a formidable task, important in various domains of research at the interface of chemistry, medicine, and nanoscience. A novel class of dipeptides, termed as β-breaker dipeptides (BBDPs), is identified, which can be incorporated into the self-recognizing sequences to gener...

journal_title：ACS chemical neuroscience

authors： Nadimpally KC,Paul A,Mandal B

更新日期：2014-05-21 00:00:00

abstract：:Herein we present the outcome of a high throughput screening (HTS) campaign-based strategy for the rapid identification and optimization of selective and general chemotypes for both kappa (κ) opioid receptor (KOR) activation and inhibition. In this program, we have developed potent antagonists (IC(50) < 120 nM) or ago...

journal_title：ACS chemical neuroscience

authors： Frankowski KJ,Hedrick MP,Gosalia P,Li K,Shi S,Whipple D,Ghosh P,Prisinzano TE,Schoenen FJ,Su Y,Vasile S,Sergienko E,Gray W,Hariharan S,Milan L,Heynen-Genel S,Mangravita-Novo A,Vicchiarelli M,Smith LH,Streicher JM,

更新日期：2012-03-21 00:00:00

abstract：:Oligomers of amyloid β-protein (Aβ) are thought to be the proximal toxic agents initiating the neuropathologic process in Alzheimer's disease (AD). Therefore, targeting the self-assembly and oligomerization of Aβ has been an important strategy for designing AD therapeutics. In parallel, research into the metallobiolog...

journal_title：ACS chemical neuroscience

authors： Mason AJ,Hurst I,Malik R,Siddique I,Solomonov I,Sagi I,Klärner FG,Schrader T,Bitan G

更新日期：2020-08-05 00:00:00

abstract：:Amyloid fibrils are the most distinct components of the plaques associated with various neurodegenerative diseases. Kinetic studies of amyloid fibril formation shed light on the microscopic mechanisms that underlie this process as well as the contributions of internal and external factors to the interplay between diff...

journal_title：ACS chemical neuroscience

authors： Nasir I,Linse S,Cabaleiro-Lago C

更新日期：2015-08-19 00:00:00

abstract：:Alzheimer's disease (AD) is a slow-progressing disease of the brain characterized by symptoms such as impairment of memory and other cognitive functions. AD is associated with an inflammatory process that involves astrocytes and microglial cells, among other components. Astrocytes are the most abundant type of glial c...

journal_title：ACS chemical neuroscience

authors： De Vita T,Albani C,Realini N,Migliore M,Basit A,Ottonello G,Cavalli A

更新日期：2019-03-20 00:00:00

abstract：:Post-translational modifications of proteins are ubiquitous in living organisms, as they enable an accurate control of the interactions of these macromolecules. For mechanistic studies, it would be highly advantageous to be able to produce in vitro post-translationally modified proteins with site-specificity. Here, we...

journal_title：ACS chemical neuroscience

authors： Lindstedt PR,Taylor RJ,Bernardes GJL,Vendruscolo M

更新日期：2021-01-19 00:00:00

abstract：:3-Iodobenzoyl naltrexamine (IBNtxA) is a potent analgesic belonging to the pharmacologically diverse 6β-amidoepoxymorphinan group of opioids. We present the synthesis and pharmacological evaluation of five analogs of IBNtxA. The scaffold of IBNtxA was modified by removing the 14-hydroxy group, incorporating a 7,8 doub...

journal_title：ACS chemical neuroscience

authors： Váradi A,Marrone GF,Eans SO,Ganno ML,Subrath JJ,Le Rouzic V,Hunkele A,Pasternak GW,McLaughlin JP,Majumdar S

更新日期：2015-11-18 00:00:00

abstract：:Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain s...

journal_title：ACS chemical neuroscience

authors： Schoenberger M,Damijonaitis A,Zhang Z,Nagel D,Trauner D

更新日期：2014-07-16 00:00:00

abstract：:The nonmedical (i.e., recreational) misuse of synthetic cannabinoids (SCs) is a worldwide public health problem. When compared to cannabis, the misuse of SCs is associated with a higher incidence of serious adverse effects, suggesting the possible involvement of noncannabinoid sites of action. Here, we find that, unli...

journal_title：ACS chemical neuroscience

authors： Yano H,Adhikari P,Naing S,Hoffman AF,Baumann MH,Lupica CR,Shi L

更新日期：2020-05-20 00:00:00

abstract：:Central norepinephrine (NE) and dopamine (DA) are involved in a variety of physiological functions and behaviors. Accumulating evidence suggests that NE neurons originating from the locus coeruleus (LC) innervate DA neurons of the ventral tegmental area (VTA) and influence VTA-DA neural activity. However, the underlyi...

journal_title：ACS chemical neuroscience

authors： Park JW,Bhimani RV,Park J

更新日期：2017-09-20 00:00:00

abstract：:Modulation of the neuropeptide S (NPS) system has been linked to a variety of CNS disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, PTSD, and substance abuse. In this study, a series of diphenyltetrahydro-1H-oxazolo[3,4-α]pyrazin-3(5H)-ones were synthesized and evaluated for antagonist ac...

journal_title：ACS chemical neuroscience

authors： Hassler C,Zhang Y,Gilmour B,Graf T,Fennell T,Snyder R,Deschamps JR,Reinscheid RK,Garau C,Runyon SP

更新日期：2014-08-20 00:00:00

abstract：:Genetically encoded tools are positioned to serve a unique and critical role in bridging the gap between the genetic identity of neurons and their functional properties. However, the use of these tools is limited by our current understanding of cell-type identity. As we make technological advances that focus on captur...

journal_title：ACS chemical neuroscience

authors： Cho YK

更新日期：2015-01-21 00:00:00

abstract：:Gangliosides are biologically important glycolipids widely distributed in vertebrate cells. An important member of the ganglioside family is the monosialylganglioside GM1, which has been suggested as a potential therapeutic for Parkinson's disease. In the current study, a late-stage radiofluorination protocol was deve...

journal_title：ACS chemical neuroscience

authors： Revunov E,Johnström P,Arakawa R,Malmquist J,Jucaite A,Defay T,Takano A,Schou M

更新日期：2020-05-06 00:00:00

abstract：:Angiotensin converting enzyme (ACE) is a dipeptidyl peptidase transmembrane bound enzyme. Generally, ACE inhibitors are used for the cardiovascular disorders. ACE inhibitors are primary agents for the management of hypertension, so these cannot be avoided for further use. The present Review focuses on the implications...

journal_title：ACS chemical neuroscience

authors： Kaur P,Muthuraman A,Kaur M

更新日期：2015-04-15 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by fibrillar deposits of amyloid-β (Aβ) peptides and neurofibrillary tangles of Tau proteins. Aβ peptides are composed of 37-49 residues, among which the Aβ42 isoform is particularly toxic and aggregation-prone and is enriched in the plaques of AD brains and thus considered ce...

journal_title：ACS chemical neuroscience

authors： Xing X,Liu C,Ali A,Kang B,Li P,Ai H

更新日期：2020-01-02 00:00:00

abstract：:Human epidemiological and animal-model studies suggest that separate exposure to stress or serotonin-selective reuptake inhibitor (SSRI) antidepressants during pregnancy increases risks for neurodevelopmental disorders in offspring. Yet, little is known about the combined effects of maternal stress and SSRIs with rega...

journal_title：ACS chemical neuroscience

authors： Velasquez JC,Zhao Q,Chan Y,Galindo LCM,Simasotchi C,Wu D,Hou Z,Herod SM,Oberlander TF,Gil S,Fournier T,Burd I,Andrews AM,Bonnin A

更新日期：2019-07-17 00:00:00

abstract：:The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats. Intrathecal injection of 10 μg of morphine induced increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. After intrathecal inject...

journal_title：ACS chemical neuroscience

authors： Jin WY,Yu LC

更新日期：2010-02-17 00:00:00

abstract：:A series of bimodal metabotropic glutamate-receptor targeted MRI contrast agents has been developed and evaluated, based on established competitive metabotropic Glu receptor subtype 5 (mGluR5) antagonists. In order to directly visualize mGluR5 binding of these agents on the surface of live astrocytes, variations in th...

journal_title：ACS chemical neuroscience

authors： Mishra A,Mishra R,Gottschalk S,Pal R,Sim N,Engelmann J,Goldberg M,Parker D

更新日期：2014-02-19 00:00:00

abstract：:An intracerebral hemorrhage (ICH) is a devastating stroke that results in high mortality and significant disability in survivors. Unfortunately, the underlying mechanisms of this injury are not yet fully understood. After the primary (mechanical) trauma, secondary degenerative events contribute to ongoing cell death i...

journal_title：ACS chemical neuroscience

authors： Hackett MJ,DeSouza M,Caine S,Bewer B,Nichol H,Paterson PG,Colbourne F

更新日期：2015-05-20 00:00:00

abstract：:The accumulation and deposition of fibrillar aggregates of α-synuclein (α-syn) into Lewy bodies are the major hallmarks of Parkinson's disease (PD) for which there is no cure yet. Disrupting preformed α-syn fibrils is considered one of the rational therapeutic strategies to combat PD. Experimental studies reported tha...

journal_title：ACS chemical neuroscience

authors： Yao Y,Tang Y,Wei G

更新日期：2020-12-16 00:00:00

abstract：:Aggregation of hyperphosphorylated tau is the hallmark of several tauopathies, including Alzheimer's disease (AD). Although the mechanism underlying tau-associated neuronal damage remains unclear, it is believed that tau hyperphosphorylation is one of the key features in disease progression. A recent study demonstrate...

journal_title：ACS chemical neuroscience

authors： Tripathi T,Prakash J,Shav-Tal Y

更新日期：2019-01-16 00:00:00

abstract：:Altered intestinal permeability has been correlated with Parkinson's pathophysiology in the enteric nervous system, before manifestations in the central nervous system (CNS). The inflammatory endotoxin or lipopolysaccharide (LPS) released by gut bacteria is known to modulate α-synuclein amyloidogenesis through the for...

journal_title：ACS chemical neuroscience

authors： Bhattacharyya D,Mohite GM,Krishnamoorthy J,Gayen N,Mehra S,Navalkar A,Kotler SA,Ratha BN,Ghosh A,Kumar R,Garai K,Mandal AK,Maji SK,Bhunia A

更新日期：2019-05-15 00:00:00

abstract：:Aggregation and intracellular deposition of the protein α-synuclein is an underlying characteristic of Parkinson's disease. α-Synuclein assemblies also undergo cell-cell spreading, facilitating propagation of their cellular pathology. Understanding how cellular interactions and uptake of extracellular α-synuclein asse...

journal_title：ACS chemical neuroscience

authors： Zhang X,Wesén E,Kumar R,Bernson D,Gallud A,Paul A,Wittung-Stafshede P,Esbjörner EK

更新日期：2020-02-05 00:00:00

abstract：:We recently reported that AMP-activated protein kinase (AMPK) contributes to zinc-induced neuronal death by inducing Bim, a pro-apoptotic Bcl-2 homology domain 3-only protein, in a liver kinase B1 (LKB1)-dependent manner. Current data suggest AMPK plays key roles in excitotoxicity and ischemic brain injury, with zinc ...

journal_title：ACS chemical neuroscience

authors： Eom JW,Kim TY,Seo BR,Park H,Koh JY,Kim YH

更新日期：2019-05-15 00:00:00

abstract：:Small hydrophobic oligomers of aggregation-prone proteins are thought to be generically toxic. Here we examine this view by perturbing an early folding contact between Phe19 and Leu34 formed during the aggregation of Alzheimer's amyloid-β (Aβ40) peptide. We find that even conservative single mutations altering this in...

journal_title：ACS chemical neuroscience

authors： Das AK,Rawat A,Bhowmik D,Pandit R,Huster D,Maiti S

更新日期：2015-08-19 00:00:00

abstract：:SARS-CoV-2 remains a significant burden on human health. Several lines of evidence suggest that surveillance of sewage and waste can provide an early warning sign for COVID-19 recurrence in a community. In support, SARS-CoV-2 traces were found in sewage in several countries. With this in mind, it is notable that pests...

journal_title：ACS chemical neuroscience

authors： Siddiqui R,Khan NA

更新日期：2020-07-01 00:00:00

abstract：:We recently found that tamoxifen suppresses l-glutamate transport activity of cultured astrocytes. Here, in an attempt to separate the l-glutamate transporter-inhibitory activity from the estrogen receptor-mediated genomic effects, we synthesized several compounds structurally related to tamoxifen. Among them, we iden...

journal_title：ACS chemical neuroscience

authors： Sato K,Kuriwaki J,Takahashi K,Saito Y,Oka J,Otani Y,Sha Y,Nakazawa K,Sekino Y,Ohwada T

更新日期：2012-02-15 00:00:00

abstract：:As the intrinsic origin of the hypothesis for β-amyloid (Aβ) from Alzheimer's disease, histidine behaviors were found to play a crucial role in Aβ aggregation. To investigate the histidine behaviors during the early stage of aggregation, Aβ40/42 pentamers with different histidine isomer states were simulated at the at...

journal_title：ACS chemical neuroscience

authors： Xing X,Zhao W,Hu D,Kang B,Shi H,Lee JY,Ai H

更新日期：2019-05-15 00:00:00