Abstract：
:Aggregation of hyperphosphorylated tau is the hallmark of several tauopathies, including Alzheimer's disease (AD). Although the mechanism underlying tau-associated neuronal damage remains unclear, it is believed that tau hyperphosphorylation is one of the key features in disease progression. A recent study demonstrates that hyperphosphorylated tau (P-tau) interacts with components of the nuclear pore complex (NPC) to impair nuclear-cytoplasmic transport and contribute to tau-induced neurotoxicity. The NPC thus represents a point of convergence between pathological tau and neuronal dysfunction in AD.
journal_name
ACS Chem Neuroscijournal_title
ACS chemical neuroscienceauthors
Tripathi T,Prakash J,Shav-Tal Ydoi
10.1021/acschemneuro.8b00632subject
Has Abstractpub_date
2019-01-16 00:00:00pages
36-38issue
1issn
1948-7193journal_volume
10pub_type
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