Abstract:
:Ionic zinc is found at a high concentration in some glutamatergic vesicles of the mammalian brain. Ionic zinc is also found chelated to macromolecules in the extracellular space, constituting what has been called the "zinc veneer". In this communication we show that the zinc ionophore, pyrithione, can be used to demonstrate the presence of the veneer. Application of pyrithione without added ionic zinc to rodent hippocampal slices mobilizes extracellular zinc, which can be detected intracellularly by the zinc probe FluoZin-3. In addition, we show that ZnT3 null mice, which lack the transporter responsible for stocking synaptic vesicles, nevertheless do have a zinc veneer, albeit diminished compared to wild type animals. The presence of the zinc veneer in ZnT3 null mice may account for the absence of any marked deficit in these animals.
journal_name
ACS Chem Neuroscijournal_title
ACS chemical neuroscienceauthors
Nydegger I,Rumschik SM,Zhao J,Kay ARdoi
10.1021/cn300061zsubject
Has Abstractpub_date
2012-10-17 00:00:00pages
761-6issue
10issn
1948-7193journal_volume
3pub_type
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