Abstract：
:Around 1% of the world's population is infected with hepatitis C. The introduction of new direct-acting antiviral agents (DAAs) in 2014 has substantially improved hepatitis C treatment outcomes. Our objective was to evaluate the long-term cost effectiveness of DAAs in health care personnel (HP) with confirmed occupational diseases in Germany. A standardised database from a German statutory accident insurance was used to analyse the cost-effectiveness ratio for the DAA regimen in comparison with interferon-based triple therapies. Taking account of the clinical progression of the disease, a Markov model was applied to perform a base case analysis for a period of 20 years. The robustness of the results was determined using a univariate deterministic sensitivity analysis. The results show that treatment with DAAs is more expensive, but also more effective than triple therapies. The model also revealed that the loss of 3.23 life years can be averted per patient over the 20 years. Compared to triple therapies, DAA treatment leads to a higher sustained virologic response (SVR). Although this results in a decrease of costs in the long term, e.g., pension payments, DAA therapy will cause greater expense in the future due to the high costs of the drugs.
journal_name
Int J Environ Res Public Healthauthors
Runge M,Krensel M,Westermann C,Bindl D,Nagels K,Augustin M,Nienhaus Adoi
10.3390/ijerph17020440subject
Has Abstractpub_date
2020-01-09 00:00:00issue
2eissn
1661-7827issn
1660-4601pii
ijerph17020440journal_volume
17pub_type
杂志文章abstract：:The travelling population is increasing globally year on year. International tourist arrival figures reached 1087 million in 2013 and 1133 million in 2014; of which 53% and 54% respectively accounted for air transport. The water on board aircraft is sourced from surface or ground water; piped to a central filling poin...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph121113938
更新日期：2015-10-30 00:00:00
abstract：:We evaluated the spatiotemporal distributions of black carbon (BC) and particulate matters with aerodynamic diameters of less than 2.5 m (PM2.5) concentrations at urban diesel engine emission (DEE) hotspots of South Korea. Concentrations of BC and PM2.5 were measured at the entrance gate of two diesel bus terminals an...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14111350
更新日期：2017-11-06 00:00:00
abstract：:It is known that the elderly population has weak immune functioning and is a susceptible and high-risk group with respect to the current coronavirus disease 2019 (COVID-19) epidemic. In this study, to understand the influencing factors of COVID-19-related risks and coping behaviors of elderly individuals with respect ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17165889
更新日期：2020-08-13 00:00:00
abstract：:Emissions from biomass burning are very serious in Southeast Asia and South Asia in April. In order to explore the effect of long-range transport of biomass emissions from the Indochina Peninsula in Southwest China during the period of the southeast monsoon season and to find out the main pollution sources in local at...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17249553
更新日期：2020-12-20 00:00:00
abstract：:The ubiquitous surfactants nonylphenol (NP) and its ethoxylates (NPEOs), which are known as endocrine disrupters, have appeared in the lists of restricted chemical substances, monitoring programs, and environmental quality standards of many countries due to their adverse effects. Recent studies have reported alarming ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15020296
更新日期：2018-02-08 00:00:00
abstract：:Workplace bullying is a serious problem that hinders the provision of quality care services by seriously affecting their physical, psychological, and social health status. Workplace bullying experiences refer to verbal and nonverbal harassment, work-related harassment, and external threats. Workplace bullying response...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
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更新日期：2020-09-26 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph13070668
更新日期：2016-07-07 00:00:00
abstract：:With the ongoing flexibilization of work, new trends concerning work outside the company's premises such as coworking spaces are on the rise. Coworking spaces are designed to offer collaboration and community in furnished and equipped workspaces on a rental base. There is a growing body of scientific literature on cow...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16132379
更新日期：2019-07-04 00:00:00
abstract：:The two goals of this study were: (1) to explore the relationship of a parent's experience in prison in combination with a range of characteristics relating to the parent in prison, to the children, and to the caregiver, and (2) to explore the role of sex and nationality in this relationship. A total of 202 parents in...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph18020626
更新日期：2021-01-13 00:00:00
abstract：:Speeding is a major contributing factor to traffic crashes and frequently happens in areas where there is a mutation in speed limits, such as the transition zones that connect urban areas from rural areas. The purpose of this study is to investigate the effects of an in-vehicle audio warning system and lit speed limit...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph13070634
更新日期：2016-06-25 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17030812
更新日期：2020-01-28 00:00:00
abstract：:The article presents the results of a correlation study, aimed at quantifying the food intake of the Roma population in the South Bohemian Region. To achieve the goal, we applied the method of one-day dietary recall and frequency food analysis (non-standardized). The quantification was carried out by analysis in the N...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15020386
更新日期：2018-02-23 00:00:00
abstract：:The rapid development of short-video social network platforms provides us with anopportunity to conduct health-related advertising and recommendation. However, so far, there areno empirical evidence on whether users are willing to accept health-related short-videoadvertisements. Here, acceptance refers to purchase int...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph17051501
更新日期：2020-02-26 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph18031013
更新日期：2021-01-24 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph6031174
更新日期：2009-03-01 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph14020144
更新日期：2017-02-03 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16204026
更新日期：2019-10-21 00:00:00
abstract：BACKGROUND:E-cigarettes are purchased through multiple channels, including general retail, online, and specialty smoke and vape shops. We examine how e-cigarette users' primary purchase place relates to e-cigarette use and smoking cessation behaviors. METHODS:Probability-based samples of the U.S. population who were c...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16050724
更新日期：2019-02-28 00:00:00
abstract：:Male osteoporosis in Malaysia is a largely neglected problem. Therefore, a bone health study in men using quantitative ultrasonometry was launched as part of the Malaysian Aging Men Study in 2009-2012. This review aimed to summarize the findings of the aforementioned bone health study. The study examined the bone heal...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph13060531
更新日期：2016-05-25 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph111212969
更新日期：2014-12-12 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph9020564
更新日期：2012-02-01 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16142623
更新日期：2019-07-23 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,随机对照试验
doi：10.3390/ijerph17103678
更新日期：2020-05-23 00:00:00
abstract：:Objective: Investigate whether residential prenatal exposure to heavy metal hazardous air pollutants (HMHAPs) is associated with an increased risk of hypospadias. Methods: Data on non-syndromic hypospadias cases (n = 8981) and control patients delivered in Texas were obtained from the Texas Birth Defects Registry and ...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16060930
更新日期：2019-03-15 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15040629
更新日期：2018-03-29 00:00:00
abstract：:With rapid urbanization and increase in car ownership, ambient noise pollution resulting from diversified sources (e.g., road traffic, railway, commercial services) has become a severe environmental problem in the populated areas in China. However, research on the spatial variation of noise pollution and its potential...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15071479
更新日期：2018-07-13 00:00:00
abstract：:The purpose of the present study was to examine the effects of height-adjustable standing desks on time-series variation in sedentary behavior (SB) among primary school children. Thirty-eight children aged 11-12 years (22 boys and 16 girls) from two classes at a primary school in Nagano, Japan, participated in this st...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16111892
更新日期：2019-05-29 00:00:00
abstract：:We investigated if geologic factors are linked to elevated arsenic (As) concentrations above 5 μg/L in well water in the state of Virginia, USA. Using geologic unit data mapped within GIS and two datasets of measured As concentrations in well water (one from public wells, the other from private wells), we evaluated...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph15040787
更新日期：2018-04-18 00:00:00
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journal_title：International journal of environmental research and public health
pub_type： 杂志文章,评审
doi：10.3390/ijerph120606115
更新日期：2015-05-29 00:00:00
abstract：:Reusable tourniquets and conventional securement dressings are considered risk factors for the occurrence of reported complications and catheter-related bloodstream infections. This study's purpose is to assess the impact of single-use disposable tourniquets and advanced occlusive polyurethane dressings with reinforce...
journal_title：International journal of environmental research and public health
pub_type： 杂志文章
doi：10.3390/ijerph16183301
更新日期：2019-09-08 00:00:00
