Abstract:
BACKGROUND:The objective of this study is to compare the oncologic outcomes of CO2 transoral laser microsurgery (TLM) and radiotherapy (RT) for treatment of T1 glottic carcinoma. METHODS:A literature search was conducted in the following databases: Medline/PubMed, Web of Science, EMBASE, and the Cochrane Library. Search results were screened, and publications comparing oncologic outcomes of T1N0M0 glottic carcinoma treated with TLM or RT were included. Data was extracted independently by two authors, and publication quality was graded according to the Oxford Centre for Evidence-based Medicine. Meta-analysis was performed for overall survival, disease specific survival, laryngeal preservation, and local control. RESULTS:Sixteen studies were included in the meta-analysis, the majority being retrospective cohort studies with two prospective cohort studies. Included studies were rated as either Level II or III evidence. Meta-analysis favoured treatment with TLM for T1 glottic carcinoma patients for the following outcomes: overall survival (odds ratio [OR], 1.52; 95% confidence interval [CI], 1.07-2.14; P = 0.02), disease specific survival (OR, 2.70; CI, 1.32-5.54; P = 0.007), and laryngeal preservation (OR, 6.31; CI, 3.77-10.56; P < 0.00001). There was no difference in local control between TLM and RT in T1 glottic cancer (OR, 1.19; CI, 0.79-1.81; P = 0.40). DISCUSSION:Our study provides a current and thorough comparison of TLM and RT outcomes in T1 glottic carcinoma. Limitations of our study include lack of randomized control trials, and non-randomized allocation of patients to treatment groups. Our meta-analysis suggests that TLM is the superior modality in terms of overall survival, disease specific survival, and laryngeal preservation. Future prospective randomized controlled studies are required for confirming these findings and developing appropriate clinical practice guidelines. LEVEL OF EVIDENCE:2A; as per the Centre of Evidence Based Medicine.
journal_name
J Otolaryngol Head Neck Surgjournal_title
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeauthors
Vaculik MF,MacKay CA,Taylor SM,Trites JRB,Hart RD,Rigby MHdoi
10.1186/s40463-019-0367-2subject
Has Abstractpub_date
2019-09-03 00:00:00pages
44issue
1eissn
1916-0208issn
1916-0216pii
10.1186/s40463-019-0367-2journal_volume
48pub_type
杂志文章,meta分析abstract:BACKGROUND:A longitudinal curriculum was developed in conjunction with anesthesiologists, otolaryngologists, emergency physicians and experts in medical simulation and education. METHODS:Residents participated in four different simulation-based training modules using animal models, cadavers, task trainers, and crisis ...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-019-0332-0
更新日期:2019-02-19 00:00:00
abstract:BACKGROUND:Fish bones are of particular interest to the otolaryngologist as accidental ingestion is one of the most common reasons for otolaryngology-related emergency department referrals. Furthermore, removal of fish bones deeply lodged in the oropharynx or hypopharynx can be both hazardous and technically difficult,...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章,评审
doi:
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The use of pre-operatively applied topical tissue expansion tapes have previously demonstrated increased rates of primary closure of radial forearm free flap donor sites. This is associated with a reduced cost of care as well as improved cosmetic appearance of the donor site. Unfortunately, little is known a...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/1916-0216-43-8
更新日期:2014-04-16 00:00:00
abstract:OBJECTIVES:To compare the efficacy and side effects of ibuprofen and acetaminophen with codeine when given postoperatively following cosmetic facial surgery and to assess whether bruising is worse or the incidence of hematoma is greater when ibuprofen is taken postoperatively. DESIGN:Prospective, double-blind, randomi...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To compare NasoPore (Stryker Canada, Hamilton, ON, Canada) and a traditional middle meatal spacer (MMS) composed of Merocel ((Medtronic Xomed, Mississauga, ON, Canada) placed in a vinyl glove finger in functional endoscopic sinus surgery (FESS) with regard to postoperative bleeding, wound healing, and patient...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To study the effects of various densities of middle ear fluids on acoustic immittance and elucidate the characteristics of this study that might be beneficial for clinical use in otitis media with effusion. STUDY DESIGN:Experimental, in vivo model. MATERIALS AND METHODS:The study was performed on 12 ears of...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Recently graduated Otolaryngology - Head and Neck Surgeons (OTO-HNS) are facing an employment crisis. To date, there has been no systematic evaluation of the factors contributing to this situation, graduating OTO-HNS trainee employment rates, nor the employment concerns of these graduating residents. This inv...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-014-0037-3
更新日期:2014-09-16 00:00:00
abstract:BACKGROUND:Periorbital edema and ecchymosis following rhinoplasty is disturbing for both the patients and their surgeons. The study aim was to determine whether nasal packing after lateral osteotomies in rhinoplasty surgery increases the risk of periorbital ecchymosis post-operatively. METHODS:This was a prospective s...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-015-0075-5
更新日期:2015-06-16 00:00:00
abstract:OBJECTIVE:To compare minimally invasive parathyroidectomy (MIP) under local anesthesia (MIPULA) to minimally invasive parathyroidectomy performed under general anesthesia (MIPUGA) in terms of postoperative pain, postanesthetic side effects, patient satisfaction, and overall outcome. DESIGN:Prospective comparative coho...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to investigate cerebral hemodynamics in patients with sleep-disordered breathing of variable severity using cerebral near-infrared spectroscopy. DESIGN:Prospective study. SETTING:Tertiary training and research hospital. METHODS:The study was performed in patients referred f...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVES:This prospective study aimed to investigate the quality of life of workers in a steel factory. METHODS:The study group was composed of 16 male workers with tinnitus and 30 ears. Fifteen male workers without tinnitus and 30 ears were included into the control group. Workers were evaluated by questionnaire, p...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:The proportion of females enrolling into medical schools has been growing steadily. However, the representation of female residents among individual specialties has shown considerable variation. The purpose of this study was to compare the trends of gender representation in Otolaryngology - Head and Neck Sur...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-017-0232-0
更新日期:2017-08-29 00:00:00
abstract:INTRODUCTION:Adenoid cystic carcinoma (ACC) of the head and neck is a rare malignancy of salivary gland origin. Few epidemiologic studies exist assessing the incidence of this tumour. The purpose of the current study was to determine the incidence of ACC of the head and neck in Nova Scotia. Furthermore, we assessed sur...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Peritonsillar abscesses (PTA) are a common complication of tonsillitis. Recent global epidemiological data regarding PTAs have demonstrated increasing antimicrobial resistance patterns. No similar studies have been conducted in Canada and no Canadian study has examined the post-discharge course of treated pa...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/1916-0216-42-5
更新日期:2013-01-31 00:00:00
abstract:OBJECTIVE:To perform a systematic review of measurement tools utilized for the diagnosis of nasal septal deviation (NSD). METHODS:Electronic database searches were performed using MEDLINE (from 1966 to second week of August 2013), EMBASE (from 1966 to second week of August 2013), Web of Science (from 1945 to second we...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章,评审
doi:10.1186/1916-0216-43-11
更新日期:2014-04-24 00:00:00
abstract:OBJECTIVE:To describe residents' satisfaction with Canadian Otolaryngology-Head and Neck Surgery programs. DESIGN:Electronic survey of 21 items scored on a 5-point Likert scale. SETTING:All Canadian Otolaryngology-Head and Neck Surgery residency programs were surveyed between February and April 2008. Responses were a...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To measure the impact of chronic rhinosinusitis (CRS) on the health of Nova Scotians and evaluate the role of surgery in modifying this impact. METHODS:Nova Scotia residents with CRS referred to one otolaryngologist were enrolled. The Chronic Sinusitis Survey (CSS) and Short Form 36-Item Health Survey (SF-36...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Various methods have been described for tonsillectomy. Convincing evidence in the literature is still lacking regarding the optimal method of performing this surgical procedure. AIM:To investigate the outcome of bipolar scissors tonsillectomy and compare it to bipolar diathermy forceps tonsillectomy. METHO...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Cisplatin-induced hearing loss is frequent and severe. Antioxidants such as sodium thiosulfate (STS) can neutralize the effects of cisplatin. The objective of the trial was to test the efficacy of trans-tympanic injections of a STS gel to prevent cisplatin-induced ototoxicity. METHODS:Eligible participants ...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章,随机对照试验
doi:10.1186/s40463-019-0327-x
更新日期:2019-01-16 00:00:00
abstract:OBJECTIVE:Altered immune, inflammatory, and angiogenesis responses have been noticed in head and neck cancer, and many of these responses have been associated with a poor clinical outcome. The objective of this study was to evaluate several immune mediators in the sera of patients with squamous cell carcinoma (SCC) of ...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) is an important cause of head and neck squamous cell carcinoma (HNSCC), especially in young people. These tumours overexpress p16 and respond well to treatment. The rapid detection of HPV in patients with HNSCC may expedite treatment when p16 status is not immediately available. M...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-016-0179-6
更新日期:2017-01-06 00:00:00
abstract:BACKGROUND:HPV-associated OSCC (HPV-OSCC) has been determined to be a distinct disease entity from non-HPV associated OSCC. Patients affected by HPV-OSCC generally have a more favourable prognosis, with improved rates of locoregional control and survival compared with their non-HPV counterparts. Despite this, HPV-OSCC ...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-018-0280-0
更新日期:2018-05-09 00:00:00
abstract:OBJECTIVE:To assess the effect of in-office intranasal application of mometasone furoate (MF) gel in reducing sinonasal mucosal inflammation in patients who have undergone endoscopic sinus surgery (ESS) for chronic rhinosinusitis. STUDY DESIGN:Retrospective review. METHODS:Symptomatic post-ESS patients were evaluated...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2012-06-01 00:00:00
abstract::Due to significant differences in healthcare structure between the United States and Canada, there are unique barriers to adopting new medical technology in Canada. In this article, we describe our experience developing a transoral robotic surgery (TORS) program at Western University. Specifically, we outline the step...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/1916-0216-42-8
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:The Development of a Novel Mixed Reality (MR) Simulation. An evolving training environment emphasizes the importance of simulation. Current haptic temporal bone simulators have difficulty representing realistic contact forces and while 3D printed models convincingly represent vibrational properties of bone, t...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-014-0023-9
更新日期:2014-08-08 00:00:00
abstract:OBJECTIVE:To determine the effectiveness of providing written information in enhancing patient understanding and retention. DESIGN:A multicentre prospective randomized study was conducted in university-affiliated ambulatory surgical centres. One hundred consecutive patients seen for rhinoplasty consultation were inclu...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章,多中心研究,随机对照试验
doi:
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:To determine if awareness of oral cancer screening correlates with socioeconomic status (SES) and to determine if screening for oral cancer correlates with SES. SETTING:Data were obtained from the 2008 American National Health Interview Survey (NHIS). METHODS:Our primary measure of SES was education; addit...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:congenital anosmia is extremely rare and tends to present late. We report on a series of patients with congenital anosmia to analyze its clinical characteristics and present illustrative cases. DESIGN:retrospective chart review. SETTINGS:tertiary care centre. METHODS:thirty-five patients with congenital an...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
abstract::Congenital laryngocele is an uncommon cause of neonatal stridor. There are only a few cases reported in the literature. The authors present a successfully treated case of an infant, whose life could only be saved by urgent tracheostomy. On the 5th postoperative day endoscopic excision and marsupialization provided pat...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:10.1186/s40463-020-00430-9
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Velopharyngeal insufficiency (VPI) is an often underrecognized disorder of palatal and nasopharyngeal closure that leads to the production of hypernasal speech. However, the potential clinical association between VPI and neurofibromatosis type 1 (NF1) remains undefined in the literature. The purpose of this s...
journal_title:Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
pub_type: 杂志文章
doi:
更新日期:2012-02-01 00:00:00