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Prospective, multicentric, comparative study between sleeve gastrectomy and Roux-en-Y gastric bypass, 277 patients, 3 years follow-up.

Abstract：

BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en Y gastric bypass (LRYGB) are commonly performed, but few studies have shown superiority of one strategy over the other. OBJECTIVE:Simultaneously compare LSG and LRYGB in terms of weight loss and morbimortality over a 36-month follow-up period. SETTING:University hospital and bariatric surgery centers, France. METHODS:Prospective, comparative study between LSG and RYGBP. The primary endpoint of this study was a joint hypothesis during the 36-month follow-up: the first primary outcome pertained to the frequency of patients with an excess weight loss (EWL) greater than 50% (% EWL>50%) after LSG or RYGB; the second primary outcome was defined as a composite endpoint of at least one major complication. Secondary objectives were regression of comorbidities and improvement in quality of life. RESULTS:Two hundred and seventy-seven patients were included (91 RYGBP, 186 LSG). The mean age was 41.1±11.1 years, and average preoperative body mass index of 45.3±5.5kg/m2. After 36months, the %EWL>50% was not inferior in the case of LSG (82.2%) relative to LRYGB (82.1%); while major complications rates were significantly higher in LRYGB (15.4%) vs. LSG (5.4%, P=0.005). After 36months, all secondary objectives were comparable between groups while only gastroesophageal reflux disease (GERD) increased in LSG group and decreased in LRYGB group. CONCLUSIONS:LSG was found non-inferior to LRYGB with respect to weight loss and was associated with lower risk of major complications during a 3-year follow-up. But GERD increased in LSG group and decreased in LRYGB group.

journal_name

J Visc Surg

journal_title

Journal of visceral surgery

authors

Catheline JM,Fysekidis M,Bendacha Y,Portal JJ,Huten N,Chouillard E,Gugenheim J,Fourtanier G,Arapis K,Msika S,Fabre JM,Sodji M,Vicaut E,Dbouk R,Roussel J,Cohen R

doi

10.1016/j.jviscsurg.2019.04.013

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

497-506

issue

issn

1878-7886

pii

S1878-7886(19)30059-1

journal_volume

156

pub_type

杂志文章,多中心研究,随机对照试验

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Prospective, multicentric, comparative study between sleeve gastrectomy and Roux-en-Y gastric bypass, 277 patients, 3 years follow-up.