Abstract:
:Whereas surgical resection is the only curative treatment for liver tumors, effective treatment for isolated unresectable lesions when there is tumor progression in spite of several lines of chemotherapy remains to be found. We report herein two cases of patients treated by a 1-hour Hyperthermic Isolated Liver Perfusion (HILP) with a combination of melphalan and bevacizumab leading to complete response. The first patient had liver metastases secondary to previously resected malignant glucagonoma and the second, recurrent hepatocellular carcinoma. We used bevacizumab in association with melphalan for HILP because of the additional effect of an anti-VEGF antibody in these highly vascularized tumors and its locally restricted delivery to the isolated hepatic vascular compartment despite of its classic contraindication in association with surgery. The protocol was approved by the Ethics Committee. Enhanced CT scans during follow-up showed complete tumor necrosis as early as the second postoperative day. Patients had 27 and 7 months disease-free survival and 48 and 41 months overall survival after HILP, for neuroendocrine liver metastases and HILP plus liver transplantation for HCC respectively. Under very specific conditions, bevacizumab in HILP can provide excellent tumor response in hopeless clinical cases of liver tumors.
journal_name
J Visc Surgjournal_title
Journal of visceral surgeryauthors
Voron T,Zinzindohoué F,Journois D,Hervé C,Ponzio O,Lucas Ndoi
10.1016/j.jviscsurg.2012.10.018subject
Has Abstractpub_date
2013-02-01 00:00:00pages
60-6issue
1issn
1878-7886pii
S1878-7886(12)00119-1journal_volume
150pub_type
杂志文章abstract:AIM OF THE STUDY:Delayed hemorrhage, though rare, remains a significant source of morbidity and mortality after pancreaticoduodenectomy (PD). An important cause of this delayed hemorrhage is erosion or pseudoaneurysm formation of the gastroduodenal artery (GDA) by pancreatic enzymes and adjacent intra-abdominal sepsis....
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2015.10.007
更新日期:2016-02-01 00:00:00
abstract::The spleen and pancreas are at risk for injury during abdominal trauma. The spleen is more commonly injured because of its fragile structure and its position immediately beneath the ribs. Injury to the more deeply placed pancreas is classically characterized by discordance between the severity of pancreatic injury and...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2016.04.005
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:To determine whether the timing of removal of abdominal drainage (AD) after pancreatoduodenectomy (PD) influences the 30-day surgical site infection (30-day SSI) rate. METHODS:A multicenter randomized, intention-to-treat trial with two parallel arms (superiority of early vs. standard AD removal on SSI) was ...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jviscsurg.2018.06.006
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:Diaphragmatic rupture following blunt trauma occurs rarely. Classically described after high-velocity accidents, ruptures are often associated with multiple organ injuries. The diagnosis is sometimes difficult. The goal of this study was to analyze and to discuss the modalities of early radiologic diagnosi...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jviscsurg.2018.10.005
更新日期:2019-02-01 00:00:00
abstract:PURPOSE OF THE STUDY:To determine the statistical indicators aimed at identifying patients for whom ambulatory colectomy could be proposed without additional risk. PATIENTS AND METHODS:The medical charts of patients who benefited from scheduled colonic or rectal resection during conventional hospitalization stays betw...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2020.11.012
更新日期:2020-12-18 00:00:00
abstract::Pneumatosis cystoides intestinalis is generally benign in course and sometimes, if cysts ruptured, behave as the not uncommon cause of free air in acute abdomen. In our case, we illustrate ruptured isolated cysts of pneumatosis cystoides intestinalis are responsible for pneumoperitoneum in a 94-year-old male patient. ...
journal_title:Journal of visceral surgery
pub_type:
doi:10.1016/j.jviscsurg.2018.09.006
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Hepatectomy remains the standard treatment for large hepatocellular carcinoma (LHCC) ≥5cm. Fibrosis may constitute a contraindication for resection because of high risk of post-hepatectomy liver failure, but its impact on patient outcome and cancer recurrence remains ill defined. Our aim was to compare predi...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2017.10.015
更新日期:2018-09-01 00:00:00
abstract::Malpractice claims are a regularly increasing concern in gastrointestinal surgery. The goal of this study was to compare the current status of claims in two different French-speaking communities by a retrospective descriptive study of surgeons' experiences, from the beginning of their practice up until December 31 201...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2019.04.011
更新日期:2019-09-01 00:00:00
abstract::Obesity has become a major public health concern. More and more patients with substantial obesity require surgery including complex hepatobiliary interventions. The morphology of these patients can make surgery difficult, especially in terms of exposure. We report the case of an obese patient who required a left hemih...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2012.05.003
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Few data are available on the management of elderly rectal cancer patients, and especially on the ability to provide optimal oncological treatment. The aim of this study was to determine the feasibility and results of multimodality treatment for rectal cancer in patients 75years and older after simplified co...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2017.06.005
更新日期:2018-02-01 00:00:00
abstract::The decision to perform a bariatric surgical procedure, the conclusion of a clinical pathway in which management is individually adapted to each patient, is taken after multidisciplinary consultation. Paradoxically, the patients who would most benefit from surgery are also those who have the highest operative risk. In...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2018.01.004
更新日期:2018-06-01 00:00:00
abstract:INTRODUCTION:Post-operative adhesions after gastrointestinal surgery are responsible for significant morbidity and constitute an important public health problem. The aim of this study was to review the surgical literature to determine the incidence, consequences and the variety of possible countermeasures to prevent ad...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2011.11.006
更新日期:2012-04-01 00:00:00
abstract:INTRODUCTION:The goal of this study was to evaluate the immediate and long-term outcomes after the combined Frey and Beger procedure for chronic pancreatitis. MATERIAL AND METHODS:From March 2008 to July 2011, 50 consecutive patients with chronic pancreatitis, confirmed by pathology, underwent the combined Frey and Be...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2014.12.003
更新日期:2015-04-01 00:00:00
abstract:GOAL:The aim of this study was to objectively analyze the characteristics of abstracts submitted to the annual joint congress of the SFCD (French Society of Digestive Surgery) and the ACBHT (Association of Hepato-biliary Surgery and Transplantation), in order to identify factors associated with acceptance for presentat...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2014.04.007
更新日期:2014-06-01 00:00:00
abstract::Health care professionals are usually at a loss when it comes to medical "complaints", essentially because they lack knowledge with regard to existing litigation procedures. After a short reminder of the different rights of appeal in France, we describe how medical appeals function in other European countries. Next, w...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2019.04.001
更新日期:2019-09-01 00:00:00
abstract::Tissue engineering, which consists of the combination and in vivo implantation of elements required for tissue remodeling toward a specific organ phenotype, could be an alternative for classical techniques of esophageal replacement. The current hybrid approach entails creation of an esophageal substitute composed of a...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2015.11.009
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To assess the impact of a simple flap closing procedure by Karydakis flap (KF) after pilonidal sinus excision on the costs and healing time as compared to routine lay-open technique. METHOD:Out of 44 consecutive patients operated on for pilonidal excision (November 2013-March 2015), 17 had a Karydakis flap and...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2017.02.004
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:There have been no solid data regarding whether patients with aortic calcification (AC) who have undergone colorectal surgery are at increased risk for anastomotic leakage. Our study aim to investigate the impact of AC on anastomotic leakage (AL) and postoperative morbidity after colorectal resection. METHO...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2016.03.007
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness of tube sigmoidostomy and sigmoidopexy as effective treatment options for patients with acute uncomplicated sigmoid volvulus. METHODS:The records of 72 patients with acute uncomplicated sigmoid volvulus with obstruction who were treated by tube sigmoidostomy (Group I: n=32) and s...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2011.02.003
更新日期:2011-04-01 00:00:00
abstract::Mortality associated with pelvic and perineal trauma (PPT) has fallen from 25% to 10% in the last decade thanks to progress accomplished in medical, surgical and interventional radiology domains (Dyer and Vrahas, 2006) [1]. The management strategy depends on the hemodynamic status of the patient (stable, unstable or e...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2012.06.004
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en Y gastric bypass (LRYGB) are commonly performed, but few studies have shown superiority of one strategy over the other. OBJECTIVE:Simultaneously compare LSG and LRYGB in terms of weight loss and morbimortality over a 36-month follow-up period. ...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.jviscsurg.2019.04.013
更新日期:2019-12-01 00:00:00
abstract::Intestinal transplantation (IT) can involve small bowel transplantation alone, or be associated with liver or multivisceral transplantation. Although IT is the radical treatment for intestinal failure, home parenteral nutrition (PN) remains the treatment of choice for this disease. Indications for IT are still debated...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2012.10.008
更新日期:2012-12-01 00:00:00
abstract::Re-admission is a new concept in France, born with the advent of day-case surgery, and defined as any re-admission occurring within 30 days after surgery. The re-admission rate has increasingly come to be considered a criterion of the quality of medical care, by both the medical profession and by insurance companies. ...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2015.09.013
更新日期:2015-12-01 00:00:00
abstract::For the last 20 years, nonoperative management (NOM) of blunt hepatic trauma (BHT) has been the initial policy whenever this is possible (80% of cases), i.e., in all cases where the hemodynamic status does not demand emergency laparotomy. NOM relies upon the coexistence of three highly effective treatment modalities: ...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2016.07.005
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To define the cost of pancreatectomies and to identify factors associated with increased hospital costs after pancreatic resection. METHODS:All patients undergoing pancreatic surgery in our department between January 2008 and December 2014 were included. All complications occurring during hospitalization or ...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2018.04.003
更新日期:2018-12-01 00:00:00
abstract::Multidisciplinary management of infra-peritoneal rectal cancer has pushed back the frontiers of sphincter preservation, without impairment of carcinological outcome. However, functional intestinal sequelae, grouping together several symptoms known under the name of anterior resection syndrome (ARS), have emerged and b...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2018.03.006
更新日期:2018-10-01 00:00:00
abstract::Anastomotic leakage represents a major complication of gastrointestinal surgery, leading to increased postoperative morbidity; it the foremost cause of mortality after intestinal resection. Identification of risk factors is essential for the prevention of AL. AL can present with various clinical pictures, ranging from...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2014.10.004
更新日期:2014-12-01 00:00:00
abstract::Mesenteric hernia is a frequent cause of intestinal obstruction in childhood but is exceptional in the adult. We describe a case in a young adult without any remarkable history who presented with an acute abdomen and intestinal obstruction. ...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2018.06.007
更新日期:2018-09-01 00:00:00
abstract::Complications related to energy sources in the operating room are not well-recognized or published, despite occasionally dramatic consequences for the patient and the responsible surgeon. The goal of this study was to evaluate the risks and consequences related to use of energy sources in the operating room. PATIENTS...
journal_title:Journal of visceral surgery
pub_type: 杂志文章
doi:10.1016/j.jviscsurg.2017.12.003
更新日期:2018-09-01 00:00:00
abstract::Although many options are available for the management of perineal wounds after abdominoperineal resection, ranging from direct closure to flap reconstruction, treatment remains challenging. A better understanding of the aims, drawbacks and progress in perineal wound management after abdominoperineal rectal resection ...
journal_title:Journal of visceral surgery
pub_type: 杂志文章,评审
doi:10.1016/j.jviscsurg.2013.02.001
更新日期:2013-02-01 00:00:00