Management of oral Graft versus Host Disease with topical agents: A systematic review.

Abstract:

BACKGROUND:Oral Graft-versus-Host Disease (oGvHD) is a common complication of haematopoietic stem cell transplantation. Choosing the right topical application to be used intra orally can be a challenge. Consequently, the aim of this work is to review the effectiveness and safety of topical agents currently used in the management of the inflammatory mucosal lesions encountered in oGVHD. MATERIAL AND METHODS:We carried out electronic searches of publications up to May 2015 of the databases Pubmed, National Library of Medicine's Medline, Embase and the Cochrane Central Register of Controlled Clinical trials to identify potentially relevant studies (keywords: "oral", "graft", "versus", "host", "disease" and "treatment"). The main inclusion criterion was the reported use of a topical agent which was not intentionally swallowed when used for the treatment of oGVHD. A 3-point grading system, described by the Swedish Council on Technology Assessment in Health Care and the Centre for Reviews and Dissemination, University of York, was used to rate the methodological quality of the papers. RESULTS:From the 902 entries identified in the search, 7 studies qualifying for inclusion were analysed. Overall, there is limited evidence with regards to the effectiveness of topical steroids for oGVHD. However, the studies showed some effect of Budesonide alone and when combined with dexamethasone. Topical tacrolimus also appears to have some effect and clobetasol propionate mouthwash had a significantly better clinical response than dexamethasone mouthwash in treating oGVHD. CONCLUSIONS:As the number of clinical trials conducted is limited, there is little evidence to support the use of topical therapies to treat the inflammatory mucosal lesions found in oGVHD. High quality randomised control trials are needed in order to measure the effectiveness of any topical application for the treatment of the inflammatory mucosal lesions found in oGVHD.

authors

Albuquerque R,Khan Z,Poveda A,Higham J,Richards A,Monteiro L,Jané-Salas E,Lopez-Lopez J,Warnakulasuriya S

doi

10.4317/medoral.20968

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

e72-81

issue

1

eissn

1698-4447

issn

1698-6946

pii

20968

journal_volume

21

pub_type

杂志文章,评审
  • Solitary cystic lymph neck node metastasis of occult thyroid papillary carcinoma.

    abstract::The appearance of a solitary lateral cervical cystic mass as the only initial presenting symptom of occult thyroid carcinoma is uncommon. Its presence is often misdiagnosed due to the more frequent branchial cyst in young people. Although oronasopharyngeal squamous cell carcinoma has been reported as the main cause of...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: González-García R,Román-Romero L,Sastre-Pérez J,Rodríguez-Campo FJ,Naval-Gías L

    更新日期:2008-12-01 00:00:00

  • Amlodipine-induced gingival hyperplasia.

    abstract::Drug-induced gingival hyperplasia is a serious concern both for the patient and the clinician. A 45 year-old Caucasian male patient with hypertension, who received amlodipine (10 mg/day, single dose orally) for two months, sought medical attention because of the new-onset gingival enlargement. On clinical examination ...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:

    authors: Lafzi A,Farahani RM,Shoja MA

    更新日期:2006-11-01 00:00:00

  • Angioleiomyoma affecting the lips: report of 3 cases and review of the literature.

    abstract::Angioleiomyoma is an uncommon benign soft tissue tumor usually found in the lower extremities and rarely observed in oral tissues. It is microscopically characterized as a proliferation of smooth muscle cells intermingled with abundant vascular channels. Oral angioleiomyomas affect mostly the lips, palate, buccal muco...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:10.4317/medoral.16.e482

    authors: Gueiros LA,Romañach MJ,Pires-Soubhia AM,Pires FR,Paes-de-Almeida O,Vargas PA

    更新日期:2011-07-01 00:00:00

  • Sclerotherapy for the recurrent granulomatous epulis with pingyangmycin.

    abstract:BACKGROUND:Relapse of granulomatous epulis is common after surgery because of local irritations, hormonal level in vivo, or incomplete resection. Currently, if recurrence occurs, then extraction of the teeth adjacent to the lesion is commonly performed, which may influence the aesthetics or masticatory function. Thus, ...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.21422

    authors: Cai Y,Sun R,He KF,Zhao YF,Zhao JH

    更新日期:2017-03-01 00:00:00

  • Accuracy combining different brands of implants and abutments.

    abstract:OBJECTIVE:To evaluate the vertical misfit between different brands of dental implants and prosthetic abutments, with or without mechanical torque, and to study their possible combination. STUDY DESIGN:Five different brands of implant were used in the study: Biofit (Castemaggiore, Italy), Bioner S.A. (Barcelona, Spain)...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.18137

    authors: Solá-Ruíz MF,Selva-Otaolaurruchi E,Senent-Vicente G,González-de-Cossio I,Amigó-Borrás V

    更新日期:2013-03-01 00:00:00

  • Clinicopathological evaluation of 164 dental follicles and dentigerous cysts with emphasis on the presence of odontogenic epithelium in the connective tissue. The hypothesis of "focal ameloblastoma".

    abstract:OBJECTIVES:Some ameloblastomas presumably originate from odontogenic epithelium within the connective tissue of dental follicles and dentigerous cysts. Therefore, it would seem reasonable to discuss as whether odontogenic epithelium proliferations, frankly displaying ameloblastomatous features ("focal ameloblastoma"), ...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.18372

    authors: Meleti M,van der Waal I

    更新日期:2013-01-01 00:00:00

  • Diagnostic evaluation of serial sections of labial salivary gland biopsies in Sjögren's syndrome.

    abstract:OBJECTIVES:Sjögren's syndrome is a chronic inflammatory disease. The detection of chronic inflammatory infiltrates containing >50 lymphocytes (lymphocytic focus) per 4 mm2 tissue in minor salivary gland biopsies is a diagnostic parameter of the disease. The aim of the study was to examine if an increase in the tissue a...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: Scardina GA,Spanó G,Carini F,Spicola M,Valenza V,Messina P,Maresi E

    更新日期:2007-12-01 00:00:00

  • Pycnodysostosis. A report of 3 clinical cases.

    abstract::Pycnodysostosis is a rare clinical entity, first described in 1962 by Maroteaux and Lamy. It is a genetic disorder, usually diagnosed at an early age. However, the diagnosis is sometimes late, made as a result of bone fracture, given the severe bone fragility resulting from increased bone density. Oral and maxillofaci...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:

    authors: Alves Pereira D,Berini Aytés L,Gay Escoda C

    更新日期:2008-10-01 00:00:00

  • Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries.

    abstract:BACKGROUND:Retrospective studies to assess the distribution of oral diseases (ODs) are helpful in estimating the prevalence of oral diagnoses in the population, and thus help in preventive and curative services. Prevalence and frequency data for ODs are available from many countries, but information from Chile is scarc...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:10.4317/medoral.21665

    authors: Rivera C,Jones-Herrera C,Vargas P,Venegas B,Droguett D

    更新日期:2017-05-01 00:00:00

  • Antibiotic prophylaxis for the prevention of infective endocarditis for dental procedures is not associated with fatal adverse drug reactions in France.

    abstract:BACKGROUND:One of the major reasons to stop antibiotic prophylaxis (AP) to prevent infective endocarditis (IE) in the United Kingdom but not in the rest of the world was that it would result in more deaths from fatal adverse drug reactions (ADRs) than the number of IE deaths. The main aim of this study was to quantify ...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.22818

    authors: Cloitre A,Duval X,Tubiana S,Giraud P,Veyrac G,Nosbaum A,Gouraud A,Mahé J,Lesclous P

    更新日期:2019-05-01 00:00:00

  • Specific (granulomatous) oral lesions of sarcoidosis: report of two cases.

    abstract::Sarcoidosis is a multisystemic granulomatous disease of unknown aetiology that usually presents with bilateral hiliar adenopathies, pulmonary infiltrations, and ocular and cutaneous lesions. The specific cutaneous lesions, or granulomatous, are produced in from 9% to 37% of patients with systemic sarcoidosis. Neverthe...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: Marcoval J,Mañá J

    更新日期:2010-05-01 00:00:00

  • Three-dimensional cone-beam computed tomography for diagnosis of keratocystic odontogenic tumours; evaluation of four cases.

    abstract::The keratocystic odontogenic tumour (KCOT), formerly known as the odontogenic keratocyst (OKC) is a benign intraosseous lesion that derives from remnants of the dental lamina. Due to its characteristics, clinical and histopathological features and various treatment approaches, this pathology is different comparing wit...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.17629

    authors: Koçak-Berberoğlu H,Çakarer S,Brkić A,Gürkan-Koseoglu B,Altuğ-Aydil B,Keskin C

    更新日期:2012-11-01 00:00:00

  • Merkel cell carcinoma of the head and neck: report of seven cases.

    abstract::Merkel cell carcinoma is a rare and aggressive primary cutaneous neoplasm. Clinically it is characterized by innocuous appearance, as a fast growing asymptomatic nodule or plaque. Head and neck are the most common sites of presentation (50%). The treatment is based on local surgery completed with cervical lymph node d...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:

    authors: Luaces Rey R,Fernández Alba J,Martín R,García Rozado A,Paradela S,Robles O,López Cedrún JL

    更新日期:2008-06-01 00:00:00

  • Molecular genetic study of novel biomarkers for early diagnosis of oral squamous cell carcinoma.

    abstract:OBJECTIVES:Early detection and treatment of an oral squamous cell carcinoma (OSCC) is critical because of its rapid growth, frequent lymph-node metastasis, and poor prognosis. However, no clinically-valuable methods of early diagnosis exist, and genetic analysis of OSCCs has yielded no biomarkers. STUDY DESIGN:We inve...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.20229

    authors: Yong-Deok K,Eun-Hyoung J,Yeon-Sun K,Kang-Mi P,Jin-Yong L,Sung-Hwan C,Tae-Yun K,Tae-Sung P,Soung-Min K,Myung-Jin K,Jong-Ho L

    更新日期:2015-03-01 00:00:00

  • No association between periodontal disease and GHQ-12 in a Brazilian Police population.

    abstract:OBJECTIVES:We attempt to investigate a possible association between periodontal disease (PD) and mental disorders (MD) in a population of Brazilian Police. STUDY METHOD:From a total study population consisting of 803 policemen, 345 police officers were obtained by a sample calculation using the finite population corre...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: Godinho EL,Farias LC,Aguiar JC,Martelli-Júnior H,Bonan PR,Ferreira RC,De Paula AM,Martins AM,Guimarães AL

    更新日期:2011-09-01 00:00:00

  • Odontogenic calcificant cystic tumor: a report of two clinical cases.

    abstract::Odontogenic Calcificant Cystic Tumor (OCCT) is an infrequent injury. It arises from odontogenic epithelial rests present in the maxilla, jaw or gum. Gorlin and col. described the OCCT for first time as an own pathological entity in 1962. Clinically, the OCCT represents 1% of the odontogenic injuries. It is possible to...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:

    authors: Reyes D,Villanueva J,Espinosa S,Cornejo M

    更新日期:2007-03-01 00:00:00

  • Intra-alveolar chlorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study.

    abstract:PURPOSE:Chlorhexidine is a good prophylactic agent for post-extraction dry socket alveolitis. The bio-adhesive 0.2% chlorhexidine gel could improve this action since its intra-alveolar positioning would allow a more direct action on the alveolus and more prolonged action of the medication. MATERIALS AND METHOD:We pres...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Torres-Lagares D,Infante-Cossio P,Gutierrez-Perez JL,Romero-Ruiz MM,Garcia-Calderon M,Serrera-Figallo MA

    更新日期:2006-03-01 00:00:00

  • Correlation between periodontal disease management and metabolic control of type 2 diabetes mellitus. A systematic literature review.

    abstract:BACKGROUND:Diabetes and periodontal disease share common features in terms of inflammatory responses. Current scientific evidence suggests that treatment of periodontal disease might contribute to glycemic control. The objective of the study is a review of the last three years. MATERIAL AND METHODS:A literature search...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:10.4317/medoral.21048

    authors: Pérez-Losada FL,Jané-Salas E,Sabater-Recolons MM,Estrugo-Devesa A,Segura-Egea JJ,López-López J

    更新日期:2016-07-01 00:00:00

  • Florid osseous dysplasia: report of a case presenting acute cellulitis.

    abstract::In this review, we examined a 45-year-old Asian man who had been diagnosed with florid osseous dysplasia (FOD) of the mandible and acute perimandibular cellulitis. This presentation occurred after a history of off-and-on swellings of the jaw and multiple treatments received at another hospital. An aggressive resection...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: Pitak-Arnnop P,Dhanuthai K,Chaine A,Bertrand JC,Bertolus C

    更新日期:2009-09-01 00:00:00

  • Transoral robotic surgery vs open surgery in head and neck cancer. A systematic review of the literature.

    abstract:BACKGROUND:TORS has become one of the latest surgical alternatives in the treatment of oropharynx squamous cell carcinomas (OPSCC) and has become increasingly accepted by surgeons as a treatment option. Surgical robots were designed for various purposes, such as allowing remote telesurgery, and eliminating human factor...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,meta分析

    doi:10.4317/medoral.23632

    authors: Roselló À,Albuquerque R,Roselló-Llabrés X,Marí-Roig A,Estrugo-Devesa A,López-López J

    更新日期:2020-09-01 00:00:00

  • Denture hyperplasia with areas simulating oral inverted ductal papilloma.

    abstract::Denture hyperplasia is a reactive lesion of the oral mucosa, usually associated to an ill-fitting denture. This lesion is easily diagnosed and in some cases distinct microscopic variations such as osseous, oncocytic and squamous metaplasia may be found. These metaplastic alterations probably are associated with the ly...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: Vargas PA,Perez DE,Jorge J,Rangel AL,León JE,Almeida OP

    更新日期:2005-07-01 00:00:00

  • Hybrid layers of etch-and-rinse versus self-etching adhesive systems.

    abstract:OBJECTIVE:To evaluate the effectiveness in the formation of resin tags, adhesive lateral branches and hybrid layers of five adhesive systems, when bonding to dentine. MATERIAL AND METHODS:Flat dentin surfaces from 25 molars were bonded with several adhesive systems according to the manufacturers' instructions. Composi...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.15.e112

    authors: Albaladejo A,Osorio R,Toledano M,Ferrari M

    更新日期:2010-01-01 00:00:00

  • P53 gene codon 72 polymorphism in patients with oral squamous cell carcinoma in the population of northern Iran.

    abstract:OBJECTIVES:Squamous cell carcinoma is the most common cancer of the oral cavity, and several etiologic factors are involved in its developing. Single nucleotide polymorphism (SNP) of the P53 gene codon 72 (P53c72) changes the structure of the protein and affects its activity. The prevalence of P53c72 different genotype...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.19794

    authors: Sina M,Pedram M,Ghojazadeh M,Kochaki A,Aghbali A

    更新日期:2014-11-01 00:00:00

  • Impact of public preventive programmes on oral quality of life of 11 to 12-yr-old school students.

    abstract:OBJECTIVES:The objective was to analyze the impact of preventive programmes on oral quality of life in school students aged 11-12 yrs. STUDY DESIGN:In the school year 1996/97, a quasi-experimental study was initiated in Granada province with four groups of students aged 6-7 yrs: Sealant + Fluoride (sealants on first p...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: Hita Iglesias C,Prados Atienza MB,Bravo M,Prados Sánchez E,Muñoz Soto E,González Rodríguez MP

    更新日期:2007-09-01 00:00:00

  • Expression of NF-κB and IL-6 in oral precancerous and cancerous lesions: An immunohistochemical study.

    abstract:BACKGROUND:The purpose of this study was to evaluate the immunohistochemical expression of NF-κB and IL-6 in oral premalignant and malignant lesions and to investigate their possible correlation with the presence of subepithelial inflammation. MATERIAL AND METHODS:Thirty two oral premalignant lesions, clinically compa...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.20570

    authors: Kamperos G,Nikitakis N,Sfakianou A,Avgoustidis D,Sklavounou-Andrikopoulou A

    更新日期:2016-01-01 00:00:00

  • Periodontal diseases as bacterial infection.

    abstract::The periodontal disease is conformed by a group of illnesses affecting the gums and dental support structures. They are caused by certain bacteria found in the bacterial plaque. These bacteria are essential to the onset of illness; however, there are predisposing factors in both the host and the microorganisms that wi...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4321/s1699-65852005000300002

    authors: Bascones-Martínez A,Figuero-Ruiz E

    更新日期:2004-01-01 00:00:00

  • Erupted odontomas: a report of three cases and review of the literature.

    abstract:INTRODUCTION:Odontomas are benign odontogenic tumors composed of enamel, dentine, cement and pulp tissue. They are usually clinically asymptomatic, but often associated with tooth eruption disturbances. In exceptional cases the odontoma erupts into the mouth . The present study reports three cases of odontomas erupted ...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,评审

    doi:

    authors: Serra-Serra G,Berini-Aytés L,Gay-Escoda C

    更新日期:2009-06-01 00:00:00

  • Patient's perception of the events during and after osteogenic alveolar distraction.

    abstract:OBJECTIVE:The aim of the study was to evaluate the patient s perception of the events during and after an osteogenic alveolar distraction (OAD) procedure MATERIALS AND METHODS:A total of fifty-five (55) osteogenic alveolar distraction (OAD) procedures were performed in fifty (50) patients, who then were asked to answe...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:

    authors: Allais M,Maurette PE,Mazzonetto R,Filho JR

    更新日期:2007-05-01 00:00:00

  • Oral findings in secondary syphilis.

    abstract:BACKGROUND:Syphilis is a sexually transmitted disease caused by Treponema pallidum. However, there are of hematogenic and vertical transmission. All health care professionals must be aware of the manifestations of this condition, such as oral lesions. OBJECTIVES:This study to analyze and compare four clinical cases of...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章

    doi:10.4317/medoral.22196

    authors: de Andrade RS,de Freitas EM,Rocha BA,Gusmão ES,Filho MR,Júnior HM

    更新日期:2018-03-01 00:00:00

  • Odontogenic tumors: a retrospective study of four Brazilian diagnostic pathology centers.

    abstract:OBJECTIVE:This article presents the results of a retrospective study of the frequency and classification of odontogenic tumors recorded at four centers of diagnostic pathology in Rio de Janeiro, Brazil. STUDY DESIGN:All medical records and microscopic slides of odontogenic tumor specimens for the years 1997 to 2007 we...

    journal_title:Medicina oral, patologia oral y cirugia bucal

    pub_type: 杂志文章,多中心研究

    doi:10.4317/medoral.17630

    authors: da-Costa DO,Maurício AS,de-Faria PA,da-Silva LE,Mosqueda-Taylor A,Lourenço SD

    更新日期:2012-05-01 00:00:00