Abstract:
OBJECTIVES:Early detection and treatment of an oral squamous cell carcinoma (OSCC) is critical because of its rapid growth, frequent lymph-node metastasis, and poor prognosis. However, no clinically-valuable methods of early diagnosis exist, and genetic analysis of OSCCs has yielded no biomarkers. STUDY DESIGN:We investigated the expression of genes associated with inflammation in OSCCs via a quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) analysis of microarray data. Tumor and normal tissues from five patients with an OSCC were used for microarray analysis. Differentially-expressed genes, identified using permutation, local pooled error (LPE), t-tests, and significance analysis of microarrays (SAM), were selected as candidate genetic markers. RESULTS:Two groups corresponding to tissue identity were evident, implying that their differentially-expressed genes represented biological differences between tissues. Fifteen genes were identified using the Student's paired t-test (p<0.05) and the SAM, with a false discovery rate of less than 0.02. Based on gene expression, these 15 genes can be used to classify an OSCC. A genetic analysis of functional networks and ontologies, validated by using a qRT-PCR analysis of the tissue samples, identified four genes, ADAM15, CDC7, IL12RB2 and TNFRSF8, that demonstrated excellent concordance with the microarray data. CONCLUSIONS:Our study demonstrated that four genes (ADAM15, CDC7, IL12RB2 and TNFRSF8) had potential as novel biomarkers for the diagnosis and the treatment of an OSCC.
journal_name
Med Oral Patol Oral Cir Bucaljournal_title
Medicina oral, patologia oral y cirugia bucalauthors
Yong-Deok K,Eun-Hyoung J,Yeon-Sun K,Kang-Mi P,Jin-Yong L,Sung-Hwan C,Tae-Yun K,Tae-Sung P,Soung-Min K,Myung-Jin K,Jong-Ho Ldoi
10.4317/medoral.20229subject
Has Abstractpub_date
2015-03-01 00:00:00pages
e167-79issue
2eissn
1698-4447issn
1698-6946pii
20229journal_volume
20pub_type
杂志文章abstract::The periodontal disease is conformed by a group of illnesses affecting the gums and dental support structures. They are caused by certain bacteria found in the bacterial plaque. These bacteria are essential to the onset of illness; however, there are predisposing factors in both the host and the microorganisms that wi...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4321/s1699-65852005000300002
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:To evaluate the changes in the peri-implant soft tissues of convergent collar implants with biologically oriented preparation technique (BOPT) crowns, 10 months after loading. MATERIAL AND METHODS:A pilot study was carried out from January 2016 to October 2017 involving 14 patients with one or two implants ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.22946
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine the prevalence of level IIb metastasis in patients with oral squamous cell carcinomas (OSCCs). MATERIAL AND METHODS:A prospective analysis of 56 patients with OSCC who underwent surgical treatment of the primary lesion with simultaneous neck dissection was performe...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.20491
更新日期:2015-09-01 00:00:00
abstract::Pycnodysostosis is a rare clinical entity, first described in 1962 by Maroteaux and Lamy. It is a genetic disorder, usually diagnosed at an early age. However, the diagnosis is sometimes late, made as a result of bone fracture, given the severe bone fragility resulting from increased bone density. Oral and maxillofaci...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2008-10-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective controlled study is the comparison between long-term children survived leukaemia and a control group in terms of the decayed, missing or filled permanent teeth (DMFT) and dental anomalies. STUDY DESIGN:Fifty-two long term children survived leukaemia, aged from 8 to 15 years (27 fe...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.17955
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVES:The primary aim of this study was to assess the prevalence of sinus tracts in endodontically treated teeth in an Iranian population. The second aim was to seek and analyze the relationship between the clinically detected sinus tracts and factors such as sex, age, tooth type and location. STUDY DESIGN:A tota...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.16.e296
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:To determine whether there is a relationship between the total BP dose administered and the variations in serum CTX concentration. STUDY DESIGN:The study included 50 patients requiring dental implant surgery and treated with oral BPs, seen in an Oral Surgery and Implantology Unit between January 2007 and Ju...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.17583
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVES:The aim of this report is to present the results of a scanning electron microscopic study on the presence of matrix vesicles (MVs) found in human dentine. STUDY DESIGN:Dentin tissue from 20 human bicuspids was analyzed by means of scanning electron microscopy. RESULTS:MVs were found as outgrowths of the ce...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.18650
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Lichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literatu...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:10.4317/medoral.21606
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To study nanostructural dentinal changes produced by endodontic irrigants. STUDY DESIGN:Experimental study. Nanoindentations were performed on peritubular (PD) and intertubular dentine (ID) with an atomic force microscopy. Stiffness and adhesion force were determined before and after application of 5.25% sod...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.18713
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The aim of this in vitro experimental study was to perform histological evaluation of the thermal effect produced on soft tissue irradiated with CO2, Er,Cr:YSGG or diode lasers. STUDY DESIGN:Porcine oral mucosa samples were irradiated with Er,Cr:YSGG laser at 1 W with and without water / air spray, at 2 W wi...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.15.e912
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVES:It has been reported that clinical changes due to hypersensitivity reactions to various foods, preservatives, and oral hygiene products may be consistent with the characteristic signs of orofacial granulomatosis (OFG). The objective of this study was to examine 37 well-documented cases of cinnamon-induced co...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Among the oral potentially malignant disorders, leukoplakia stands out as the most prevalent. The purpose of this study was to analyse the clinical-pathological features of oral leukoplakia in groups of patients from three major pathology centers in two different regions of Brazil, in order to determine whic...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.24175
更新日期:2020-11-28 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a placebo for pain and inflammation control after third molar surgery. MATERIAL AND METHODS:A gel combining 0.2% chlorhexdine, 0.5% chitosan, 5% de...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,随机对照试验
doi:10.4317/medoral.23661
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:A comparison was made between the electromyographic patterns specific to patient with temporomandibular disorders and that of normal healthy patients. STUDY DESIGN:Electromyographic tests were carried out during rest and function of the masseter muscles and anterior temporalis muscles in a homogeneous group...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.15.e14
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology. MATERIAL AND METHODS:An electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge, and Google-Scholar ...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:10.4317/medoral.21887
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:This article presents the results of a retrospective study of the frequency and classification of odontogenic tumors recorded at four centers of diagnostic pathology in Rio de Janeiro, Brazil. STUDY DESIGN:All medical records and microscopic slides of odontogenic tumor specimens for the years 1997 to 2007 we...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,多中心研究
doi:10.4317/medoral.17630
更新日期:2012-05-01 00:00:00
abstract:UNLABELLED:Diabetes mellitus type 2 is the most common metabolic disorder and it causes an important morbimortality. The structural modifications in the parotid gland (sialosis) had already been described in these patients and could result in variations in the salivary composition, as well as an increase in periodontal...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2006-07-01 00:00:00
abstract::Leiomyoma, a benign neoplasia arising from smooth muscle is an uncommon neoplasia of the oral cavity. The most common histological subtype in the oral cavity is the vascular one. To supplement information on vascular leiomyoma of the oral cavity (VLOC), we present cases of VLOC describing their clinical, histological,...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章,评审
doi:
更新日期:2008-08-01 00:00:00
abstract::Metastases in the oral cavity are rare lesions which represent approximately 1% of all malignant neoplasms in the oral cavity. Oral metastases are located in the mandible 80-90% on average, the maxilla location being rarer. Metastases in mouth soft tissue are also rare, and within these it is on the gums where they mo...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::Worldwide, the use of cocaine has an increased over the years, various secondary effects have been described. Here we present a 48 years old female with a 2-month evolution bucconasal ulcer in the hard palate induced by cocaine usage accompanied by swallow and phonation dysfunctions. Ethiopathogenesis, differential di...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:To investigate the relative frequency of localized mucosal swellings of the upper and lower labial mucosa, the clinical-pathological diagnosis agreement and whether patient's age and gender and tumor's site and size may raise the suspicion of neoplasm. MATERIAL AND METHODS:Retrospective analysis was perform...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.23933
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVES:1. - To measure the alveolar resorption processes that occur in patients wearing mandibular overdentures on 2 implants and fully-removable maxillary dentures, and to evaluate the same process on patients wearing fully-removable dentures on both arches. 2.- To verify whether Kelly's Combination Syndrome occur...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Oropharyngeal mucositis (OM) is one of the main side-effects of oncological therapy. There is no treatment to prevent its occurrence, but some zinc-based therapies have been proven to help in decreasing its intensity. The objective of this study was to determine the effect of zinc in OM in children with acut...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.23798
更新日期:2020-11-01 00:00:00
abstract:AIM:To visualize by atomic force microscopy the alterations induced on Enterococcus. faecalis surface after treatment with 2 types of laser: Erbium chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser and Diode laser. MATERIAL AND METHODS:Bacterial suspensions from overnight cultures of E. faecalis were irradia...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.19991
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Third molar extraction is a very common procedure in Dentistry. The aim of this study was to evaluate the quality of life (QoL) and satisfaction of patients undergoing extraction of an upper third molar under local anesthesia. A second objective was to describe the evolution of self-reported pain measured in...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.21781
更新日期:2017-11-01 00:00:00
abstract:AIM:To determine the prevalence of oral lesions (OL) in patients with psoriasis, and compare these findings with the ones found in patients without this condition. MATERIALS AND METHODS:In the present observational and comparative study, we evaluated 207 patients, with and without psoriasis, attending the dermatologic...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2008-11-01 00:00:00
abstract::There are few studies on bucco-maxillary lesions in children and adolescents, and reports on odontogenic tumors (OT) are scanty. Comparison among the available data is difficult due to differences in the criteria used in each study. The aim of the present work was to perform a retrospective study of OT in patients age...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Oral ulcers caused by methotrexate (MTX) at low doses are a known side effect of this drug. Although increasingly more patients are medicated with MTX, these painful ulcers, without traumatic origin and resistant to any type of treatment, are not usually identified by health professionals as a side effect of...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.22851
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:This study aims to assess, in the population of patients with oral cancer treatment, the influence on the quality of life of two protocols of dental treatment: not ruled hospital treatment versus ruled hospital treatment. Matrial and Methods: A quasi-experimental approach justified on ethical grounds was use...
journal_title:Medicina oral, patologia oral y cirugia bucal
pub_type: 杂志文章
doi:10.4317/medoral.22353
更新日期:2018-07-01 00:00:00