Abstract:
:Antipsychotic drugs such as clozapine and olanzapine are associated with an increased risk for type 2 diabetes, but relatively little is known about the relationship between risk factors for type 2 diabetes established in the general population and type 2 diabetes in people with psychosis. We estimated the prevalence of established risk factors and their association with type 2 diabetes in a nationally representative sample of people with an ICD-10 psychosis (N=1642) who gave a fasting blood sample (N=1155). Logistic regression was used to summarize associations adjusted for age and sex. In this sample, whose mean duration of psychosis was 14.7 years, 12.1% (13.1% of women and 11.5% of men) had type 2 diabetes at age 18-64 years based on current fasting blood glucose levels or treatment with a hypoglycaemic drug. Risk was greatly increased in young adults compared with the general population and peaked in middle age. Risk factors in the general population were common in people with psychosis and strongly associated with type 2 diabetes in those people. Treatment with clozapine was associated with an increased risk and treatment with olanzapine with a decreased risk for type 2 diabetes. The development of diabetes or pre-diabetes may therefore influence the likelihood of treatment with olanzapine over time. The strongest predictors of type 2 diabetes in a multivariate model were a body mass index of at least 40 and treated hypercholesterolemia, followed by a body mass index between 35 and 39.9, a family history of diabetes and treated hypertension. There was minimal to no confounding of the association between type 2 diabetes and current clozapine or olanzapine treatment, but neither association remained significant after adjustment for other predictors. Longitudinal relationships among predictors are likely to be complex, and previous antipsychotic drug treatment may at least partly explain risks associated with severe obesity, dyslipidemia and hypertension. A focus on weight loss is warranted in people with psychosis, but prevention strategies for type 2 diabetes should be broadened to include those with emerging dyslipidemia, hypertension and a family history of diabetes.
journal_name
World Psychiatryauthors
Foley DL,Mackinnon A,Morgan VA,Watts GF,McGrath JJ,Castle DJ,Waterreus A,Galletly CAdoi
10.1002/wps.20130subject
Has Abstractpub_date
2014-06-01 00:00:00pages
176-83issue
2eissn
1723-8617issn
2051-5545journal_volume
13pub_type
杂志文章相关文献
World Psychiatry文献大全abstract::This paper summarizes the findings for the Latin American and Caribbean countries of the WPA Task Force on Steps, Obstacles and Mistakes to Avoid in the Implementation of Community Mental Health Care. It presents an overview of the provision of mental health services in the region; describes key experiences in Argenti...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/j.2051-5545.2012.tb00130.x
更新日期:2012-10-01 00:00:00
abstract::Studies from North America have concluded that supported employment using the Individual Placement and Support (IPS) model is effective in helping individuals with severe and persistent mental illness gain competitive employment. The aim of this study was to investigate the effectiveness and cost-effectiveness of IPS ...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/j.2051-5545.2011.tb00035.x
更新日期:2011-06-01 00:00:00
abstract::In 2008, the National Institute of Mental Health (NIMH) included in its new Strategic Plan the following aim: "Develop, for research purposes, new ways of classifying mental disorders based on dimensions of observable behavior and neurobiological measures". The implementation of this aim was named the Research Domain ...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20087
更新日期:2014-02-01 00:00:00
abstract::Disastrous events in the country and the region caused a 13.5% increase in the prevalence of mental and behavioral disorders in Serbia in the last few years, thus making them the second largest public health problem. Due to prolonged adversities, the health system has deteriorated and is facing specific challenges. Ho...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::Post-traumatic stress disorder (PTSD) should be one of the most preventable mental disorders, since many people exposed to traumatic experiences (TEs) could be targeted in first response settings in the immediate aftermath of exposure for preventive intervention. However, these interventions are costly and the proport...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20150
更新日期:2014-10-01 00:00:00
abstract::Although cognitive behaviour therapy (CBT) is the treatment of choice for post-traumatic stress disorder (PTSD), there is no evidence of its success with PTSD patients still under direct threat of terrorist attacks. This study reports the first randomized controlled trial of CBT for PTSD terrorist-affected people. Twe...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/j.2051-5545.2011.tb00058.x
更新日期:2011-10-01 00:00:00
abstract::The term quality of life (Qol) has become a rallying cry for all those who strive to integrate patients' subjective experience of their life during illness into clinical care. With its intuitive appeal, Qol seems to be understood by everyone involved in managing health and disease. However, when examining the ever inc...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2006-10-01 00:00:00
abstract::Psychiatrists would undoubtedly support the notion of promoting such qualities as empathy, sensitivity and caring in the pursuit of good clinical practice. However, cultivating what we may call the "art of psychiatry" is not straightforward, since the qualities that constitute it are elusive. I propose that the means ...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2005-10-01 00:00:00
abstract::The reporting of child sexual abuse (CSA) and physician-patient sexual relationships (PPSR) are currently the focus of professional, legal and media attention in several countries. This paper briefly reviews mental health policies on these issues and reports on a WPA survey of them. While the WPA Madrid Declaration pe...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/j.2051-5545.2009.tb00210.x
更新日期:2009-02-01 00:00:00
abstract::Metabolic syndrome and other cardiovascular risk factors are highly prevalent in people with schizophrenia. Patients are at risk for premature mortality and overall have limited access to physical health care. In part these cardio-metabolic risk factors are attributable to unhealthy lifestyle, including poor diet and ...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/j.2051-5545.2009.tb00199.x
更新日期:2009-02-01 00:00:00
abstract::A meta-analysis was conducted to explore the risk for cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia and age- and gender- or cohort-matched general population controls. Our literature search generated 203 relevant studies, of which 136 were included. The final...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20069
更新日期:2013-10-01 00:00:00
abstract::Although enormous progress has been made in the treatment of schizophrenia, and the use of existing pharmacologic agents can have a dramatic effect on the short- and long-term management of the disorder, enormous challenges and unmet needs continue to exist. Despite the introduction of a second generation of antipsych...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2003-06-01 00:00:00
abstract::A rather large body of literature now exists on the use of telemental health services in the diagnosis and management of various psychiatric conditions. This review aims to provide an up-to-date assessment of telemental health, focusing on four main areas: computerized CBT (cCBT), Internet-based CBT (iCBT), virtual re...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20218
更新日期:2015-06-01 00:00:00
abstract::Substance use is a major cause of disability globally. This has been recognized in the recent United Nations Sustainable Development Goals (SDGs), in which treatment coverage for substance use disorders is identified as one of the indicators. There have been no estimates of this treatment coverage cross-nationally, ma...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20457
更新日期:2017-10-01 00:00:00
abstract::In this paper we report the clinical utility of the diagnostic guidelines for ICD-11 mental, behavioural and neurodevelopmental disorders as assessed by 339 clinicians in 1,806 patients in 28 mental health settings in 13 countries. Clinician raters applied the guidelines for schizophrenia and other primary psychotic d...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20581
更新日期:2018-10-01 00:00:00
abstract::This study examined the transcultural robustness of a screening instrument for hypomania, the Hypomania Checklist-32, first revised version (HCL-32 R1). It was carried out in 2606 patients from twelve countries in five geographic regions (Northern, Southern and Eastern Europe, South America and East Asia). In addition...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/j.2051-5545.2010.tb00268.x
更新日期:2010-02-01 00:00:00
abstract::Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this review, we examine the recent research on the relationship of insight with behavior, mood and perceived quality of life, on its complex roots, and on the effects of existing and emerging treatments. This research indicates that p...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20508
更新日期:2018-02-01 00:00:00
abstract::Most psychotherapies for depression have been developed in high-income Western countries of North America, Europe and Australia. A growing number of randomized trials have examined the effects of these treatments in non-Western countries. We conducted a meta-analysis of these studies to examine whether these psychothe...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20493
更新日期:2018-02-01 00:00:00
abstract::A timely determination of the risk of post-traumatic stress disorder (PTSD) is a prerequisite for efficient service delivery and prevention. We provide a risk estimate tool allowing a calculation of individuals' PTSD likelihood from early predictors. Members of the International Consortium to Predict PTSD (ICPP) share...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20608
更新日期:2019-02-01 00:00:00
abstract::The issue of the severity of psychiatric disorders has great clinical importance. For example, severity influences decisions about level of care, and affects decisions to seek government assistance due to psychiatric disability. Controversy exists as to the efficacy of antidepressants across the spectrum of depression...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20569
更新日期:2018-10-01 00:00:00
abstract::This paper summarizes the current situation of mental health services in the Arab world. Out of 20 countries for which information is available, six do not have a mental health legislation and two do not have a mental health policy. Three countries (Lebanon, Kuwait and Bahrain) had in 2007 more than 30 psychiatric bed...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1016/j.wpsyc.2012.01.008
更新日期:2012-02-01 00:00:00
abstract::The tragedy of maternal filicide, or child murder by mothers, has occurred throughout history and throughout the world. This review of the research literature sought to identify common predictors in the general population as well as in correctional and psychiatric samples. Further research is needed to improve identif...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2007-10-01 00:00:00
abstract::Schizophrenia is characterized by positive symptoms, negative symptoms and cognitive impairment. Positive symptoms may be related to excessive dopamine (DA) function, as suggested by the common antidopaminergic properties of antipsychotic medications, which are most effective at treating positive symptoms. Negative sy...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2003-10-01 00:00:00
abstract::Major depressive disorder (MDD) is a prevalent and disabling condition, and many patients do not respond to available treatments. Deep transcranial magnetic stimulation (dTMS) is a new technology allowing non-surgical stimulation of relatively deep brain areas. This is the first double-blind randomized controlled mult...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20199
更新日期:2015-02-01 00:00:00
abstract::There is an enormous gap between the burden of mental disorders and mental health resources in low- and middle-income countries. The Mental Health: Global Action Programme of the World Health Organization (WHO) envisions an active role for research in the multidimensional efforts required to change the current mental ...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract::Depression is widely acknowledged to be a heterogeneous entity, and the need to further characterize the individual patient who has received this diagnosis in order to personalize the management plan has been repeatedly emphasized. However, the research evidence that should guide this personalization is at present fra...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20771
更新日期:2020-10-01 00:00:00
abstract::Although non-adherence is common across all branches of medicine, psychotic disorders pose additional challenges that increase its risk. Despite the importance of non-adherence, clinicians generally spend too little time on assessing and addressing adherence attitudes and behaviors. Importantly, how adherence is measu...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20060
更新日期:2013-10-01 00:00:00
abstract::Cognitive behavior therapy (CBT), as exemplified by the model of psychotherapy developed and refined over the past 40 years by A.T. Beck and colleagues, is one of the treatments of first choice for ambulatory depressive and anxiety disorders. Over the past several decades, there have been vigorous efforts to adapt CBT...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20149
更新日期:2014-10-01 00:00:00
abstract::Metabolic syndrome (MetS) and its components are highly predictive of cardiovascular diseases. The primary aim of this systematic review and meta-analysis was to assess the prevalence of MetS and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:10.1002/wps.20252
更新日期:2015-10-01 00:00:00
abstract::Uganda has passed through political and bloody civil strife stretching over 40 years. Since 1987 the HIV/AIDS pandemic has compounded the problems of the country. The present paper describes some initiatives to develop mental health services in one district of the country. A bottom-up approach in the district resulted...
journal_title:World psychiatry : official journal of the World Psychiatric Association (WPA)
pub_type: 杂志文章
doi:
更新日期:2007-02-01 00:00:00