Abstract：
:Acrylamide (ACR) is a water-soluble chemical used in different industrial and laboratory processes. ACR monomer is neurotoxic in humans and laboratory animals. Subchronic exposure to this chemical causes neuropathies, hands and feet numbness, gait abnormalities, muscle weakness, ataxia, skin and in some cases, cerebellar alterations. ACR neurotoxicity involves mostly the peripheral but also the central nervous system, because of damage to the nerve terminal through membrane fusion mechanisms and tubulovescicular alterations. Nevertheless, the exact action mechanism is not completely elucidated. In this paper we have reviewed the current literature on its neurotoxicity connected to work-related ACR exposure. We have analyzed not only the different pathogenetic hypotheses focusing on possible neuropathological targets, but also the critical behavior of ACR poisoning. In addition we have evaluated the ACR-exposed workers case studies. Despite all the amount of work which have being carried out on this topic more studies are necessary to fully understand the pathogenetic mechanisms, in order to propose suitable therapies.
journal_name
Int J Environ Res Public Healthauthors
Pennisi M,Malaguarnera G,Puglisi V,Vinciguerra L,Vacante M,Malaguarnera Mdoi
10.3390/ijerph10093843subject
Has Abstractpub_date
2013-08-27 00:00:00pages
3843-54issue
9eissn
1661-7827issn
1660-4601pii
ijerph10093843journal_volume
10pub_type
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