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The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials.

Abstract：

:An engineered nanomaterial (ENM) may actually consist of a population of primary particles, aggregates and agglomerates of various sizes. Furthermore, their physico-chemical characteristics may change during the various life-cycle stages. It will probably not be feasible to test all varieties of all ENMs for possible health and environmental risks. There is therefore a need to further develop the approaches for risk assessment of ENMs. Within the EU FP7 project Managing Risks of Nanoparticles (MARINA) a two-phase risk assessment strategy has been developed. In Phase 1 (Problem framing) a base set of information is considered, relevant exposure scenarios (RESs) are identified and the scope for Phase 2 (Risk assessment) is established. The relevance of an RES is indicated by information on exposure, fate/kinetics and/or hazard; these three domains are included as separate pillars that contain specific tools. Phase 2 consists of an iterative process of risk characterization, identification of data needs and integrated collection and evaluation of data on the three domains, until sufficient information is obtained to conclude on possible risks in a RES. Only data are generated that are considered to be needed for the purpose of risk assessment. A fourth pillar, risk characterization, is defined and it contains risk assessment tools. This strategy describes a flexible and efficient approach for data collection and risk assessment which is essential to ensure safety of ENMs. Further developments are needed to provide guidance and make the MARINA Risk Assessment Strategy operational. Case studies will be needed to refine the strategy.

journal_name

Int J Environ Res Public Health

journal_title

International journal of environmental research and public health

authors

Bos PM,Gottardo S,Scott-Fordsmand JJ,van Tongeren M,Semenzin E,Fernandes TF,Hristozov D,Hund-Rinke K,Hunt N,Irfan MA,Landsiedel R,Peijnenburg WJ,Sánchez Jiménez A,van Kesteren PC,Oomen AG

doi

10.3390/ijerph121214961

subject

Has Abstract

pub_date

2015-11-27 00:00:00

pages

15007-21

issue

eissn

1661-7827

issn

1660-4601

pii

ijerph121214961

journal_volume

pub_type

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The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials.