Abstract:
:Candida albicans, which can cause superficial and life-threatening systemic infections, is the most common opportunistic fungal pathogen in the human microbiome. The two-component system is one of the most important C. albicans signal transduction pathways, regulating the response to oxidative and osmotic stresses, adhesion, morphogenesis, cell wall synthesis, virulence, drug resistance, and the host-pathogen interactions. Notably, some components of this signaling pathway have not been found in the human genome, indicating that the two-component system of C. albicans can be a potential target for new antifungal agents. Here, we summarize the composition, signal transduction, and regulation of the two-component system of C. albicans to emphasize its essential roles in the pathogenesis of C. albicans and the new therapeutic target for antifungal drugs.
journal_name
Virulencejournal_title
Virulenceauthors
Liao B,Ye X,Chen X,Zhou Y,Cheng L,Zhou X,Ren Bdoi
10.1080/21505594.2021.1949883keywords:
["Candida albicans","Histidine protein kinase","Phosphorelay","Response regulator","Two-component systems"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
1884-1899issue
1eissn
2150-5594issn
2150-5608journal_volume
12pub_type
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