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Fibrinogen and smooth muscle cell detection in atherosclerotic plaques from stable and unstable angina -- an immunohistochemical study.

Abstract：

BACKGROUND:This study presents a systematic analysis of atherothrombotic lesions taken by percutaneous atherectomy and post mortem examination from coronary arteries, in order to identify: a) the topographic occurrence of fibrinogen and smooth muscle cells (SMCs), b) their independent expression in stable and unstable plaques, and c) their co-expression, which can provide a better understanding of the involvement of fibrinogen and SMCs in the development and progression of atherosclerotic plaques. MATERIAL/METHODS:120 specimens from atherosclerotic lesions were collected, using directional coronary atherectomy; 40 additional specimens were collected from postmortem examinations. All specimens were stained by immunohistochemical methods with monoclonal and polyclonal antibodies (DAKO) for fibrinogen and SMCs. RESULTS:Fibrinogen appeared to be a component of all stable and unstable coronary atherosclerotic plaques, with a significant predominance in unstable angina. No significant difference was observed between SMC-stained areas in stable and unstable angina; however, a significant difference exists in co-expression of SMCs and fibrinogen between unstable and stable angina. Interestingly, the total number of SMCs at the first stages of formation of unstable plaques is less than in stable plaques. However, in a number of advanced coronary atherosclerotic plaques associated with unstable angina, we observed an increasingly progressive inflammatory cell activity, in which SMC areas were significantly increased. CONCLUSIONS:This distribution of fibrinogen and SMCs suggests the possibility of a link between SMC migration and proliferation, intensifying the increased fibrinogen concentration in atherosclerotic plaques.

journal_name

Med Sci Monit

journal_title

Medical science monitor : international medical journal of experimental and clinical research

authors

Loukas M,Dabrowski M,Wagner T,Walczak E,Witkowski A,Ruzyłło W

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

BR144-8

issue

eissn

1234-1010

issn

1643-3750

pii

2070

journal_volume

pub_type

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Fibrinogen and smooth muscle cell detection in atherosclerotic plaques from stable and unstable angina -- an immunohistochemical study.