Abstract：
:1. By study of the synthesis and turnover of brain monoamines and with the use of behavioral models which indicate the functional activity of brain 5HT and dopamine, it is possible to unravel the mechanisms by which some drugs produce behavioral effects. 2. Using these techniques the acute and chronic effects of certain neuroleptics, propranolol and other beta-adrenergic blocking agents, repeated electroconvulsive shock, and lithium upon the functional activity of brain 5HT and dopamine are examined. 3. The clinical relevance of these studies is discussed.
journal_name
Prog Neuropsychopharmacoljournal_title
Progress in neuro-psychopharmacologyauthors
Grahame-Smith DGdoi
10.1016/0364-7722(79)90065-1subject
Has Abstractpub_date
1979-01-01 00:00:00pages
15-23issue
1-3eissn
0364-7722issn
0278-5846journal_volume
3pub_type
杂志文章,评审abstract：:1. The first part of the paper is devoted to a critical review on the possible relationships between depression and monoamine oxidase. 2. This study describes the results of an investigation of MAO-activity in depression, using new approaches and methodology. This methodology was developed because the literature data ...
journal_title：Progress in neuro-psychopharmacology
pub_type： 杂志文章
doi：10.1016/0364-7722(79)90000-6
更新日期：1979-01-01 00:00:00
abstract：:1. Communication among scientists of similar professional interest is an often neglected but critical factor in medical research and practice. 2. Dissemination of information is vital for keeping abreast of one's field, for planning studies and treatment regimens, and for avoiding unnecessary research. 3. Today's comm...
journal_title：Progress in neuro-psychopharmacology
pub_type： 杂志文章
doi：10.1016/0364-7722(79)90077-8
更新日期：1979-01-01 00:00:00
abstract：:1. Some recent findings on fetal alcohol effects are presented under the headings of introduction, classification--clinical signs and symptoms, epidemiology, etiology--possible pathogenesis, diagnosis, prognosis, management, discussion and conclusions. 2. The present level of knowledge suggests that the toxic effects ...
journal_title：Progress in neuro-psychopharmacology
pub_type： 杂志文章,评审
doi：10.1016/0364-7722(79)90001-8
更新日期：1979-01-01 00:00:00
abstract：:1. The range of tricyclic antidepressant plasma levels (or doses) needed for therapeutic response remains largely unresolved, since quantal plasma concentration (or dose)--response relationships have not been clearly defined for either therapeutic or nontherapeutic effects. 2. The fact that certain patients apparently...
journal_title：Progress in neuro-psychopharmacology
pub_type： 杂志文章,评审
doi：10.1016/0364-7722(79)90085-7
更新日期：1979-01-01 00:00:00
abstract：:1. AHR-6646 blocked d-amphetamine lethality in mice under aggregated conditions when the pretreatment interval was between one hour and seven days. 2. Conditioned avoidance responding in mice and cats was suppressed by AHR-6646 in doses that did not impair escape behavior. The duration of this effect was markedly prol...
journal_title：Progress in neuro-psychopharmacology
pub_type： 杂志文章
doi：10.1016/0364-7722(79)90005-5
更新日期：1979-01-01 00:00:00
abstract：:Muscimol, ibotenic acid, isoguvacine, 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin-3-ol (THIP) and gamma-aminobutyric acid (GABA) injected intravenously exerted the following dose-dependent effects on the lumbosacral spinal cord of spinal cats: 1. The excitability of primary afferents and the amplitude of dorsal root re...
journal_title：Progress in neuro-psychopharmacology
pub_type： 杂志文章
doi：10.1016/0364-7722(79)90045-6
更新日期：1979-01-01 00:00:00
abstract：:1. The effects of apomorphine and sodium Di-n-propylacetate (DPA, sodium valproate) on pain-induced aggressive behavior were investigated in three inbred strains of mice: BALB/c, C57B1/6 and DBA/2, which exhibited spontaneously low levels of aggression. 2. Apomorphine elicited aggressive behavior in the three strains,...
journal_title：Progress in neuro-psychopharmacology
pub_type： 杂志文章
doi：10.1016/0364-7722(79)90003-1
更新日期：1979-01-01 00:00:00
