Association between miR-212-3p and SOX11, and the effects of miR-212-3p on cell proliferation and migration in mantle cell lymphoma.

abstract：:Mitochondria are central to a variety of cellular processes, from metabolism to cell death. In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma. Increased cytochrome c expression was also cor...

journal_title：Oncology letters

authors： Wilkinson ST,Johnson DB,Tardif HL,Tome ME,Briehl MM

更新日期：2010-03-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are considered to be significant environmental carcinogens. Additionally, various planar ring systems are capable of intercalating with DNA, leading to a number of drugs that possess chemotherapeutic activity. In this study, three new polyaromatic compounds with a side chain wer...

journal_title：Oncology letters

authors： Bandyopadhyay D,Granados JC,Short JD,Banik BK

更新日期：2012-01-01 00:00:00

abstract：:A number of studies have shown that cyclooxygenase-2 (COX-2) gene polymorphisms were associated with gastric cancer. However, the results from different research groups have not been consistent. The present study aimed to investigate the association between polymorphisms of the cyclooxygenase-2 promoter region (-1195G...

journal_title：Oncology letters

authors： Li Y,Dai L,Zhang J,Wang P,Chai Y,Ye H,Zhang J,Wang K

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of glyceollins on the suppression of tumorigenesis in triple-negative breast carcinoma cell lines. We further explored the effects of glyceollins on microRNA and protein expression in MDA-MB-231 cells. Triple-negative (ER-, PgR- and Her2/neu-) breast carcinoma c...

journal_title：Oncology letters

authors： Rhodes LV,Tilghman SL,Boue SM,Wang S,Khalili H,Muir SE,Bratton MR,Zhang Q,Wang G,Burow ME,Collins-Burow BM

更新日期：2012-01-01 00:00:00

abstract：:Gastric cancer (GC) is the fourth most common cancer and the second most common cause of cancer-associated mortality worldwide. Approximately 10% of gastric cancers are hereditary and a small percentage of these cases (1-3%) have been classified as a single hereditary syndrome (hereditary diffuse gastric cancer). We p...

journal_title：Oncology letters

authors： Zuk K,Peczek L,Stec-Michalska K,Medrek M,Nawrot B

更新日期：2012-01-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is one of the most frequently occurring types of cancer worldwide. We focused on the fact that the aberrant function of Wnt/β-catenin signaling is a frequent event in malignancies. Dickkopf (Dkk)-3 is a major negative regulator of Wnt/β-catenin signaling, which is a known ...

journal_title：Oncology letters

authors： Katase N,Lefeuvre M,Gunduz M,Gunduz E,Beder LB,Grenman R,Fujii M,Tamamura R,Tsujigiwa H,Nagatsuka H

更新日期：2012-02-01 00:00:00

abstract：:Protein kinase AKT mediates cell proliferation and survival signals, and also contributes to cancer progression. Increased expression and/or activation of AKT is involved in a variety of human cancers. In cells treated with sage or rosemary extract, mRNA and protein expression levels of AKT1 were reduced compared with...

journal_title：Oncology letters

authors： Okumura N,Yoshida H,Nishimura Y,Kitagishi Y,Matsuda S

更新日期：2012-02-01 00:00:00

abstract：:Urea derivatives have been widely used in biology and medicine. The substituted urea derivative URD12 introduced in this study exhibits cytotoxic activity against the K562 human leukemia and KB human mouth epidermal carcinoma cell lines. To further study the bioactivity of URD12 and examine its feasibility as a new an...

journal_title：Oncology letters

authors： Wang AY,Lu Y,Zhu HL,Jiao QC

更新日期：2012-02-01 00:00:00

abstract：:Acute lymphoblastic leukemia (ALL), cancer of the white blood cells, is a heterogeneous disease that mainly occurs due to the malignant cloning of original and naive lymphocytes. The aim of this study was to explore the immunophenotype, the percentage of CD4(+)CD25(+) regulatory T cells (Tregs) and the expression of c...

journal_title：Oncology letters

authors： Wu CP,Qing X,Wu CY,Zhu H,Zhou HY

更新日期：2012-02-01 00:00:00

abstract：:CD8(+) T cells play critical roles in immunosurveillance by killing malignant or virally infected cells. Interleukin 15 (IL-15) is a critical cytokine for promoting proliferation and the effector capacity of CD8(+) T cells, and has been used to support the growth of CD8(+) T cells in cellular therapies of neoplastic d...

journal_title：Oncology letters

authors： Qian L,Zhang Y,Pan XY,Ji MC,Gong WJ,Tian F

更新日期：2012-02-01 00:00:00

abstract：:Targeting tumor-specific receptors is a promising approach for cytotoxic agents. The orexin 2 receptor (OX2R) has reportedly been expressed in a few types of cancer, but not in normal, cells. This study aimed to explore and assess the expression levels of OX2R in a wide range of cancer cell lines and clinical samples ...

journal_title：Oncology letters

authors： Kishida M,Ishige K,Horibe T,Tada N,Koibuchi N,Shoda J,Kita K,Kawakami K

更新日期：2012-03-01 00:00:00

abstract：:The present study aimed to retrospectively evaluate the efficacy and toxicities of adjuvant chemotherapy with paclitaxel and carboplatin (TC) following concurrent cisplatin-based chemoradiation (CCRT) in patients with cervical cancer with lymphadenopathy (N1). A total of 37 patients with FIGO stage IB2-IVA cervical ca...

journal_title：Oncology letters

authors： Abe A,Furumoto H,Nishimura M,Irahara M,Ikushima H

更新日期：2012-03-01 00:00:00

abstract：:FAS and its ligand FASL are crucial in apoptotic cell death. Loss of FAS and gain of aberrant FASL expression are common features of malignant transformation. This study was designed to investigate whether the functional polymorphisms of FAS -1377G/A (rs2234767) and FASL -844T/C (rs763110) affect the risk of developin...

journal_title：Oncology letters

authors： Wang W,Zheng Z,Yu W,Lin H,Cui B,Cao F

更新日期：2012-03-01 00:00:00

abstract：:The purpose of this study was to determine whether computed tomographic scans and attenuation measurements on contrast material-enhanced and non-enhanced computed tomographic scans could be used to characterize solitary pulmonary nodules and, in particular, to characterize these lesions using washout characteristics o...

journal_title：Oncology letters

authors： Ye XD,Ye JD,Yuan Z,Dong S,Xiao XS

更新日期：2012-03-01 00:00:00

abstract：:It has been reported that treating cancer cells with dichloroacetate (DCA), an approved treatment for congenital lactic acidosis, reverses the Warburg effect and inhibits tumor growth). Furthermore, omeprazole (OMP) is a well-known agent that enhances the effects of anticancer drugs. The aim of this study was to find ...

journal_title：Oncology letters

authors： Ishiguro T,Ishiguro M,Ishiguro R,Iwai S

更新日期：2012-03-01 00:00:00

abstract：:Fibronectin 1 (FN1) is a glycoprotein that is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defenses and metastasis. The aim of this study was to elucidate the FN1 protein expression in renal cell carcinoma (RCC) and to determine its potential prognos...

journal_title：Oncology letters

authors： Steffens S,Schrader AJ,Vetter G,Eggers H,Blasig H,Becker J,Kuczyk MA,Serth J

更新日期：2012-04-01 00:00:00

abstract：:The outcomes of treatment of physical illnesses are strongly affected by the presence of schizophrenia. We aimed to quantify the clinical course of schizophrenic breast cancer patients who were eligible for adjuvant chemotherapy to determine whether patients with this mental illness receive appropriate treatment for t...

journal_title：Oncology letters

authors： Hwang M,Farasatpour M,Williams CD,Margenthaler JA,Virgo KS,Johnson FE

更新日期：2012-04-01 00:00:00

abstract：:Breast cancer is a highly malignant disease in women. A convenient screening tool with high accuracy for early detection, not only in high-risk individuals but in the general population, is necessary. Two hundred breast cancer patients, 100 healthy controls and 100 hyperplasia patients were enrolled in this study. Sam...

journal_title：Oncology letters

authors： Gong B,Xue J,Yu J,Li H,Hu H,Yen H,Hu J,Dong Q,Chen F

更新日期：2012-04-01 00:00:00

abstract：:Recently, high-risk human papillomavirus (HPV) has emerged as a possible agent associated with head and neck squamous cell carcinoma (HNSCC) in younger patients. Therefore, the purpose of the present study was to assess the effect of age on the distribution of HPV-16/18 in HNSCC, together with the impact of the virus ...

journal_title：Oncology letters

authors： Marques-Silva L,Farias LC,Fraga CA,de Oliveira MV,Cardos CM,Fonseca-Silva T,Gomes CC,De-Paula AM,Gomez RS,Guimarães AL

更新日期：2012-04-01 00:00:00

abstract：:The aim of this study was to evaluate the usefulness of urinary N(1),N(12)-diacetylspermine (DiAcSpm) measured by the colloidal gold aggregation method as a tumor marker for colorectal cancer (CRC). The preoperative urine of 113 CRC patients was collected, and the urinary DiAcSpm was measured by a reagent kit for DiAc...

journal_title：Oncology letters

authors： Nakayama Y,Torigoe T,Minagawa N,Yamaguchi K

更新日期：2012-05-01 00:00:00

abstract：:Teratoma is a tumor that forms triploblastic tissues and the common sites of occurrence are sacrococcygeal lesions and the ovaries. The majority of cases are curable with surgical resection and the prognosis depends on the extent and histological scoring of the tumor. In the present study, we report a case of sacrococ...

journal_title：Oncology letters

authors： Takamatsu M,Aoki H,Hirose Y,Kobayashi K,Tomita H,Kuno T,Koumura H,Hara A

更新日期：2012-05-01 00:00:00

abstract：:The John Cunningham virus (JCV) infects a large proportion of the population worldwide and may cause progressive multifocal leukoencephalopathy upon immunodeficiency. Recent reports provided evidence of its oncogenetic role in malignancies. In this study, JCV was examined by targeting T antigen, viral protein and agno...

journal_title：Oncology letters

authors： Wang JP,Wang ZZ,Zheng YS,Xia P,Yang XH,Liu YP,Takano Y,Zheng HC

更新日期：2012-05-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) and its receptor c-Met are important in the development and homeostasis of a variety of human malignancies. However, the role of the HGF/c-Met signaling pathway in nasopharyngeal carcinoma (NPC) has not been clearly elucidated. This study examined the effect of HGF/c-Met on proliferation...

journal_title：Oncology letters

authors： Sun R,Zhang Q,Guo L,Chen MY,Sun Y,Cao B,Sun J

更新日期：2012-05-01 00:00:00

abstract：:Taxanes inhibit the disassembly of microtubules, which are involved in mitosis and axoplasmatic transport, and may cause the degeneration of peripheral, mainly small, sensory nerves. Peripheral neurotoxicity is a dose-limiting side-effect of taxanes. Neuroprotective agents may aid in the reduction of neurotoxicity, th...

journal_title：Oncology letters

authors： Imai A,Matsunami K,Takagi H,Ichigo S

更新日期：2012-06-01 00:00:00

abstract：:The role of Rab coupling protein (RCP) has not been previously investigated in squamous cell carcinoma of the head and neck (SCCHN). The aim of this study was to explore RCP protein expression and its clinicopathological significance in SCCHN. RCP protein expression in 95 SCCHN samples, 18 vocal nodule epithelia and 1...

journal_title：Oncology letters

authors： Dai Y,Liu Y,Huang D,Yu C,Cai G,Pi L,Ren C,Chen GZ,Tian Y,Zhang X

更新日期：2012-06-01 00:00:00

abstract：:RhoA, an extensively studied member of the Rho GTPase family, has been identified as a mediator of pro-inflammatory responses and aggressive carcinogenesis. Bacterial lipopolysaccharide (LPS) is known to be a potent stimulator of inflammatory cytokine production. LPS is able to alter the activity of RhoA and the subce...

journal_title：Oncology letters

authors： Tao Y,Chen YC,Lan T,Qian H,Wang Y,Jiang L

更新日期：2012-06-01 00:00:00

abstract：:The aim of this study was to determine the methylation status of the p16(INK4a), p14(ARF) and p15(INK4b) genes and the subsequent effect of hypermethylation on the expression of these genes in cervical cancer patients. Methylation-specific PCR (MSP) was performed to analyse the methylation status of p16(INK4a), p14(AR...

journal_title：Oncology letters

authors： Jha AK,Nikbakht M,Jain V,Capalash N,Kaur J

更新日期：2012-06-01 00:00:00

abstract：:Neuroendocrine carcinoma (NEC) of the breast is a rare distinct clinicopathological entity, which, clinically, tends not to be aggressive. Mucinous carcinoma of the breast is also a rare distinct entity and is classified into types A (paucicellular) and B (hypercellular). It is well known that type B mucinous carcinom...

journal_title：Oncology letters

authors： Ishida M,Umeda T,Abe H,Tani T,Okabe H

更新日期：2012-07-01 00:00:00

abstract：:The use of CD133 as a marker for identifying and isolating colon cancer stem cells (CSCs) is controversial. In particular, it is not clear whether the pattern of expression is influenced by the tumor microenvironment. We analysed the expression of CD133 in the SW620 colon cancer cell line, which produces subpopulation...

journal_title：Oncology letters

authors： Yang Z,Wang Z,Fan Y,Zheng Q

更新日期：2012-07-01 00:00:00

abstract：:The purpose of this study was to develop predictive/prognostic markers for liver metastasis and recurrence following liver resection, investigating not only clinical parameters but also molecular markers that are known to be involved in the process of liver metastasis. Seventy colon cancer patients with either no dist...

journal_title：Oncology letters

authors： Min BS,Kim NK,Jeong HC,Chung HC

更新日期：2012-07-01 00:00:00