Epidemiology of HPV Related Malignancies.

abstract：:The most common indication for the use of radiation therapy in the treatment of benign central nervous system disease is for the treatment of benign brain tumors, such as meningioma, pituitary adenoma, acoustic neuroma, arteriovenous malformation, and craniopharyngioma. Other less common benign intracranial tumors tre...

journal_title：Seminars in radiation oncology

authors： Tsao MN,Wara WM,Larson DA

更新日期：1999-04-01 00:00:00

abstract：:Preoperative chemotherapy and chemoradiation protocols are generally associated with high clinical response rates but limited pathologic responses for large primary tumors. We have initiated a prospective phase II study of weekly paclitaxel and carboplatin plus concurrent, fractionated external-beam radiation, followe...

journal_title：Seminars in radiation oncology

authors： Wanebo HJ,Chougule P,Ready N,Koness RJ,Akerley W,McRae R,Nigri P,Leone L,Webber B,Safran H

更新日期：1999-04-01 00:00:00

abstract：:Therapy for limited-disease (LD) small cell lung cancer (SCLC) includes combined modality therapy using radiation (XRT) and systemic chemotherapy. Because such therapy is effective in treating the disease, LD SCLC is now considered potentially curable. Based on data from the Intergroup study, the current standard chem...

journal_title：Seminars in radiation oncology

authors： Ettinger DS

更新日期：1999-04-01 00:00:00

abstract：:The decision whether to offer women with one to three positive nodes postmastectomy radiation after adjuvant chemotherapy has been the subject of intense discussion since the publication of two major randomized prospective trials. Although radiotherapy after mastectomy was an established treatment for women with four ...

journal_title：Seminars in radiation oncology

authors： Kuske RR

更新日期：1999-07-01 00:00:00

abstract：:Local tumor recurrence after complete resection may be due to treatment factors or represent a manifestation of tumor biology. The association of local tumor recurrence, distant metastases, and death in patients undergoing treatment for extremity soft tissue sarcoma (STS) has been described but continues to be enigmat...

journal_title：Seminars in radiation oncology

authors： Espat NJ,Lewis JJ

更新日期：1999-10-01 00:00:00

abstract：:High-risk endometrial cancer comprises an uncommon group of tumors, which includes pathological stage III adenocarcinoma and all stages of papillary serous carcinoma. Optimal management of this class of malignant female genital neoplasms is surgical resection, including debulking of any gross abdominopelvic disease. T...

journal_title：Seminars in radiation oncology

authors： Wolfson AH

更新日期：2000-01-01 00:00:00

abstract：:The article examines current laboratory and clinical information with respect to the relative importance of tumor hypoxia to the radiation control of carcinoma of the cervix. Its impact is difficult to quantify because of interrelated important parameters, which are also operational, including inherent radiosensitivit...

journal_title：Seminars in radiation oncology

authors： Thomas GM

更新日期：1994-01-01 00:00:00

abstract：:The radiation-modifying effect of cancer chemotherapeutic drugs is reviewed based on experimental studies covering skin, esophagus, intestinal tract, lungs, kidney, bladder, testis, and hematopoietic tissue. The results obtained in experimental studies have, whenever possible, been compared with observations of normal...

journal_title：Seminars in radiation oncology

authors： von der Maase H

更新日期：1994-04-01 00:00:00

abstract：:Adjuvant radiation therapy for esophageal cancer can be delivered preoperatively andøor postoperatively. Although one series reports a significant decrease in localøregional failure and two report a survival advantage, when the data are combined, there is no clear advantage for preoperative radiation therapy. One of t...

journal_title：Seminars in radiation oncology

authors： Minsky BD

更新日期：1994-07-01 00:00:00

abstract：:Because the greatest risk for patients with locally advanced breast cancer is the development of distant metastases and death, the goals of surgery are to obtain maximal locoregional control with minimal disfigurement and to enable accurate staging to determine prognosis and subsequent adjuvant therapy. Today, most ca...

journal_title：Seminars in radiation oncology

authors： Singletary SE

更新日期：1994-10-01 00:00:00

abstract：:Retrospective analyses have shown that, following surgical resection, patients with early-stage small cell lung cancer have a survival rate comparable to that seen with non-small cell lung cancer, especially if combined modality therapy is used. Surgery has been employed in three specific instances: primary surgery fo...

journal_title：Seminars in radiation oncology

authors： Ginsberg RJ,Shepherd FA

更新日期：1995-01-01 00:00:00

abstract：:Many different electronic portal imaging devices (EPIDs) have been developed to improve geometric accuracy in radiation therapy. This article describes the two types of EPIDs that have become available commercially-the television camera-based EPID and the matrix ion chamber EPID-as well as describing the amorphous sil...

journal_title：Seminars in radiation oncology

authors： Munro P

更新日期：1995-04-01 00:00:00

abstract：:The Gamma Knife (Leksell Gamma Unit; Elekta Radiosurgery, Inc, Atlanta, GA) and specially adapted linear accelerators are the systems most commonly used for intracranial stereotactic external beam irradiation. Both systems deliver collimated radiation to a treatment isocenter and a stereotactic head frame is required ...

journal_title：Seminars in radiation oncology

authors： Coy SR,Houdek PV

更新日期：1995-07-01 00:00:00

abstract：:The application of high-dose chemotherapy and radiation followed by marrow stem cell rescue has been extensively used over the last decade in the management of relapsed and refractory lymphomas. More recently, this approach has also been evaluated as consolidation therapy in first remissions or even as primary therapy...

journal_title：Seminars in radiation oncology

authors： Yahalom J

更新日期：1995-10-01 00:00:00

abstract：:Lung cancer has been particularly recalcitrant to standard therapeutic interventions. Improvement in the outcome for this disease requires the ability to identify the disease while it is still localized in the airways. Usually, radiation therapy to eliminate this disease fails because of progression of the cancer outs...

journal_title：Seminars in radiation oncology

authors： Mulshine JL,Scott F,Zhou J,Avis I I,Vos M,Miller MJ,Szabo E,Martinez A,Treston AM,Cuttitta F,Tockman M

更新日期：1996-04-01 00:00:00

abstract：:Prognostic factors in Hodgkin's disease (HD) are reviewed. The Ann Arbor staging classification remains the basis for evaluation of patients with HD. However, subgroups of patients with differing prognoses exist within the individual stages. In pathological stages I and II, the number of involved regions and the tumor...

journal_title：Seminars in radiation oncology

authors： Specht L

更新日期：1996-07-01 00:00:00

abstract：:The current understanding of cellular responses to ionizing radiation fuses traditional radiobiological concepts with recent insight into underlying molecular mechanisms. Cell cycle arrest, induction of specific cascades of genes, and activation of DNA repair mechanisms have been reported after radiation exposure. Of ...

journal_title：Seminars in radiation oncology

authors： Jung M,Dritschilo A

更新日期：1996-10-01 00:00:00

abstract：:The management of data for three-dimensional conformal radiation therapy (3D CRT) is a multifaceted enterprise that includes image data transfer and format conversion, the safeguarding and distribution of treatment planning data, and the construction of efficient and secure user environments. Because 3D radiation ther...

journal_title：Seminars in radiation oncology

authors： Bosch WR,Purdy JA

更新日期：1997-01-01 00:00:00

abstract：:This report presents results from the facilities surveys that are useful for radiation oncology practices facing the challenges of managed care. Facilities surveys collect data from the entire census of facilities practicing megavoltage radiation therapy. Data include equipment, personnel, and patient load. The data p...

journal_title：Seminars in radiation oncology

authors： Owen JB,Coia LR

更新日期：1997-04-01 00:00:00

abstract：:Neuroblastoma (NBL) is the fourth most common pediatric malignancy. With a median age at diagnosis of 2 years, it represents half of all malignancies that present in the first month of life and one third of those that are diagnosed in the first year of life. NBL is unique among human cancers in its ability to undergo ...

journal_title：Seminars in radiation oncology

authors： Marcus KC,Tarbell NJ

更新日期：1997-07-01 00:00:00

abstract：:The use of external irradiation and 5-fluorouracil continues because of the proven benefits of this combination in the treatment of a variety of human malignancies. There are probably several mechanisms of action on the cellular level that account for radiation sensitization. One main feature of both laboratory and ap...

journal_title：Seminars in radiation oncology

authors： Rich TA

更新日期：1997-10-01 00:00:00

abstract：:Experimental radioimmunotherapy (RIT) studies in animal models have contributed significantly to the design of clinical RIT protocols, although the results have not always been directly translated. Reviewed in this article are current areas of active research in experimental RIT to increase the therapeutic ratio that ...

journal_title：Seminars in radiation oncology

authors： Buchsbaum DJ

更新日期：2000-04-01 00:00:00

abstract：:Bone pain from osteoblastic metastases can be ameliorated 40% to 80% of the time. Although we can predict nonresponders, we cannot predict responders; however, patients with a better performance scale may have a better chance of pain relief. Radiopharmaceuticals containing phosphorus 32, strontium 89, samarium 153, rh...

journal_title：Seminars in radiation oncology

authors： Silberstein EB

更新日期：2000-07-01 00:00:00

abstract：:Fewer than 15% of the 170,000 patients who develop lung cancer each year will survive their disease, which shows the need for novel, more specific, and less toxic therapeutic strategies. Recent advances in molecular biology have made it possible to ascertain which genetic alterations contribute to the etiology of canc...

journal_title：Seminars in radiation oncology

authors： Roth JA,Grammer SF,Swisher SG,Nemunaitis J,Merritt J,Meyn RE Jr

更新日期：2000-10-01 00:00:00

abstract：:Angiogenesis, the growth of new blood vessels, is a critical component in the development of solid tumors. Over the last decade, progress in the study of the biology of angiogenesis has led to identification of a large number of molecules that promote, participate, and regulate the growth of new vessels in normal tiss...

journal_title：Seminars in radiation oncology

authors： Neeman M,Provenzale JM,Dewhirst MW

更新日期：2001-01-01 00:00:00

abstract：:The management of patients with anaplastic astrocytoma (AA) requires multidisciplinary involvement. In this article, the literature on the treatment of patients with AA is reviewed, emphasizing randomized trials and key retrospective studies. The role of surgery, radiation therapy, and chemotherapy in newly diagnosed ...

journal_title：Seminars in radiation oncology

authors： Chang S,Theodosopoulos P,Sneed P

更新日期：2001-04-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is an enzyme induced by a variety of factors including tumor promoters, cytokines, growth factors and hypoxia. It is involved in the metabolic conversion of arachidonic acid to prostanoids, primarily in inflammatory states and tumors. In normal tissues, prostanoids are synthesized by COX-1, an...

journal_title：Seminars in radiation oncology

authors： Milas L

更新日期：2001-10-01 00:00:00

abstract：:Experience accumulated over several decades in the treatment of head and neck tumors by irradiation has demonstrated the need for a high tumor dose to achieve local control. With external beam irradiation alone, it is difficult to spare adjacent normal tissues, resulting in undesirable late effects on the salivary gla...

journal_title：Seminars in radiation oncology

authors： Mazeron JJ,Noël G,Simon JM

更新日期：2002-01-01 00:00:00

abstract：:A prospective randomized study was conducted to determine whether amifostine (Ethyol) reduces the rate of severe esophagitis and hematologic and pulmonary toxicity associated with chemoradiation or improves control of non-small cell lung cancer (NSCLC). Sixty patients with inoperable stage II or III NSCLC were treated...

journal_title：Seminars in radiation oncology

authors： Komaki R,Lee JS,Kaplan B,Allen P,Kelly JF,Liao Z,Stevens CW,Fossella FV,Zinner R,Papadimitrakopoulou V,Khuri F,Glisson B,Pisters K,Kurie J,Herbst R,Milas L,Ro J,Thames HD,Hong WK,Cox JD

更新日期：2002-01-01 00:00:00

abstract：:The effects of WR1065 (SH), the free thiol form of amifostine, on nuclear transcription factor kappaB (NFkappaB) activation, manganese superoxide dismutase (MnSOD) gene expression, and secretion of human vascular endothelial cell growth factor (hVEGF), basic fibroblast growth factor (bFGF), tumor necrosis factor-alpha...

journal_title：Seminars in radiation oncology

authors： Grdina DJ,Murley JS,Kataoka Y,Calvin DP

更新日期：2002-01-01 00:00:00