Molecular pathology of adamantinomatous craniopharyngioma: review and opportunities for practice.

Abstract:

:Since the first identification of CTNNB1 mutations in adamantinomatous craniopharyngioma (ACP), much has been learned about the molecular pathways and processes that are disrupted in ACP pathogenesis. To date this understanding has not translated into tangible patient benefit. The recent development of novel techniques and a range of preclinical models now provides an opportunity to begin to support treatment decisions and develop new therapeutics based on molecular pathology. In this review the authors summarize many of the key findings and pathways implicated in ACP pathogenesis and discuss the challenges that need to be tackled to translate these basic science findings for the benefit of patients.

journal_name

Neurosurg Focus

journal_title

Neurosurgical focus

authors

Apps JR,Martinez-Barbera JP

doi

10.3171/2016.8.FOCUS16307

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

E4

issue

6

issn

1092-0684

journal_volume

41

pub_type

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