当前位置： SCI文献检索 > DISEASES OF THE ESOPHAGUS期刊下所有文献 > Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma.

Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma.

Abstract：

:Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but the etiology and mode of carcinogenesis of this disease remain poorly understood. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator of Akt/mTOR pathway, frequently mutates or is inactive in many cancers. Although mTOR has been thought a promising cancer therapeutic target, the sensitivity of tumor cells to rapamycin was still to be revaluated. In this study, we measured the effects of rapamycin on cell proliferation and phosphorylation of Akt in ESCC cells with varying degrees of differentiation. And then, the relationship between PTEN status and the sensitivity of cells to rapamycin was investigated in EC9706 cells with or without wild-type PTEN in vitro and in vivo. The results demonstrated ESCC cells with poor differentiation were insensitive to rapamycin of high concentration and rapamycin obviously promoted the phosphorylation of Akt in these cells, but it had no obvious effects on p-Akt in cells with well differentiation. Also, we showed that wild-type PTEN improved the sensitivity of poor differentiation cells to rapamycin through inhibiting phosphorylation of Akt in vitro and in vivo. This study explored the possible molecular mechanism of some ESCC cells insensitive to rapamycin and provided a measure for treating ESCC patients with PTEN inactivation using mTOR inhibitors.

journal_name

Dis Esophagus

journal_title

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

authors

Lu Z,Wang J,Zheng Y,Yang S,Liu M,Chen X,Wang C,Hou G

doi

10.1111/dote.12448

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

1-8

issue

2

eissn

1120-8694

issn

1442-2050

journal_volume

30

pub_type

杂志文章

相关文献

DISEASES OF THE ESOPHAGUS文献大全
  • Progression of diffuse esophageal spasm to achalasia: incidence and predictive factors.

    abstract：:The progression of certain primary esophageal motor disorders to achalasia has been documented; however, the true incidence of this decay is still elusive. This study aims to evaluate: (i) the incidence of the progression of diffuse esophageal spasm to achalasia, and (ii) predictive factors to this progression. Thirty...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2012.01377.x

    authors： Fontes LH,Herbella FA,Rodriguez TN,Trivino T,Farah JF

    更新日期：2013-07-01 00:00:00

  • Expression of p21(Waf1/Cip1) predicts response and survival of esophageal cancer patients treated by chemoradiotherapy.

    abstract：:Chemoradiotherapy is a multimodal therapy routinely used as a primary treatment for advanced esophageal cancer. However, it is beneficial only to patients who respond. To identify pretreatment markers predicting response and survival, we examined the expression of cell cycle regulatory molecules, p53, p21(Waf1/Cip1) c...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2004.00433.x

    authors： Nakamura T,Hayashi K,Ota M,Ide H,Takasaki K,Mitsuhashi M

    更新日期：2004-01-01 00:00:00

  • Nonoperative treatment of four esophageal perforations with hemostatic clips.

    abstract：:Spontaneous or iatrogenic esophageal perforations are despite advances of modern surgery and intensive care medicine still potentially life-threatening events with a considerable mortality rate. Recently, encouraging results on the sealing of esophageal perforations by placement of endoluminal prostheses were reported...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00652.x

    authors： Fischer A,Schrag HJ,Goos M,von Dobschuetz E,Hopt UT

    更新日期：2007-01-01 00:00:00

  • The impact of the speed of food intake on gastroesophageal reflux events in obese female patients.

    abstract：:Obesity increases the risk of gastroesophageal reflux disease (GERD). The majority of the reflux attacks occur postprandially. The influence of the speed of food intake on gastroesophageal reflux events is unclear in obese patients. To determine the influence of the speed of food intake on intraesophageal reflux event...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/dote.12499

    authors： Bor S,Erdogan A,Bayrakci B,Yildirim E,Vardar R

    更新日期：2017-01-01 00:00:00

  • Neoadjuvant chemoradiotherapy followed by esophagectomy for initially resectable squamous cell carcinoma of the esophagus with multiple lymph node metastasis.

    abstract：:Neoadjuvant chemoradiotherapy (CRT) was expected to improve surgical curability and prognosis for advanced esophageal cancer. However, the clinical efficacy of neoadjuvant CRT followed by esophagectomy with three-field lymphadenectomy (3FL) for initially resectable esophageal squamous cell carcinoma (SCC) remains uncl...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2005.00521.x

    authors： Nabeya Y,Ochiai T,Matsubara H,Okazumi S,Shiratori T,Shuto K,Aoki T,Miyazaki S,Gunji Y,Uno T,Ito H,Shimada H

    更新日期：2005-01-01 00:00:00

  • Morbidity following salvage esophagectomy for squamous cell carcinoma: the MD Anderson experience.

    abstract：:The survival advantage associated with the addition of surgical therapy in esophageal squamous cell carcinoma (ESCC) patients who demonstrate a complete clinical response to chemoradiotherapy is unclear, and many institutions have adopted an organ-preserving strategy of selective surgery in this population. We sought ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doz067

    authors： Mitchell KG,Nelson DB,Corsini EM,Vaporciyan AA,Antonoff MB,Mehran RJ,Rice DC,Roth JA,Sepesi B,Walsh GL,Bhutani MS,Maru DM,Wu CC,Nguyen QN,Ajani JA,Swisher SG,Hofstetter WL

    更新日期：2020-03-16 00:00:00

  • Evolution of the surgical technique of minimally invasive Ivor-Lewis esophagectomy: description according to the IDEAL framework.

    abstract：:Totally minimally invasive Ivor-Lewis esophagectomy (Ivor Lewis TMIE) is a technically challenging procedure and is associated with a learning curve. Refinement of surgical technique is an important part of this learning curve. However, detailed descriptions of these refinements according to the idea, development, exp...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doy079

    authors： Stenstra MHBC,van Workum F,van den Wildenberg FJH,Polat F,Rosman C

    更新日期：2019-03-01 00:00:00

  • Gastroesophageal reflux disease progressing to achalasia.

    abstract：:Two achalasia patients with former complaints of heartburn were examined. Antisecretory drugs were used by the patients when dysphagia occurred. Barium X-ray and esophageal manometry were performed and achalasia was diagnosed in both patients. Twenty-four-hour pH-metry showed significant and long-lasting acid reflux d...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2005.00515.x

    authors： Király A,Illés A,Undi S,Varga G,Kalmár K,Horváth PO

    更新日期：2005-01-01 00:00:00

  • Comparison of bolus transit patterns identified by esophageal impedance to barium esophagram in patients with dysphagia.

    abstract：:Bolus transit through the esophagus has not been validated by videoesophagram in patients with dysphagia and changes in impedance with abnormal barium transit have not been described in those patients. The aim of this study was to compare esophageal impedance findings with barium esophagram measurements in patients wi...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01212.x

    authors： Cho YK,Choi MG,Oh SN,Baik CN,Park JM,Lee IS,Kim SW,Choi KY,Chung IS

    更新日期：2012-01-01 00:00:00

  • Efficacy of leukotriene receptor antagonist for erosive esophagitis: a preliminary retrospective comparative study.

    abstract：:While diagnostic overlap exists between gastroesophageal reflux disease and eosinophilic esophagitis especially on histological findings, therapeutic approaches for the two disease entities are very different. Recently, anti-inflammatory treatment, in addition to acid suppressants, has been investigated for gastroesop...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01299.x

    authors： Lee H,Park JC,Shin SK,Lee SK,Lee YC

    更新日期：2012-09-01 00:00:00

  • Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus.

    abstract：BACKGROUND AND AIMS:There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. METHODS:This is a cross-sectional study conducted at a ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/dote.12475

    authors： Pantham G,Ganesan S,Einstadter D,Jin G,Weinberg A,Fass R

    更新日期：2017-01-01 00:00:00

  • Superiority of anti-reflux stent compared with conventional stents in the palliative management of patients with cancer of the lower esophagus and esophago-gastric junction: results of a randomized clinical trial.

    abstract：:Palliation of inoperable esophageal cancer with covered stents aims to relieve progressive dysphagia and improve health-related quality of life (HRQoL). Introducing a stent across the esophagogastric junction in lower third tumors may predispose to unchecked gastro-esophageal reflux (GER). Esophageal stents incorporat...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2007.00696.x

    authors： Power C,Byrne PJ,Lim K,Ravi N,Moore J,Fitzgerald T,Keeling PW,Reynolds JV

    更新日期：2007-01-01 00:00:00

  • Primary malignant melanoma of the esophagus: a study of clinical features, pathology, management and prognosis.

    abstract：:Primary malignant melanoma of the esophagus (PMME) is a rare disease that is characterized by aggressive invasion, early metastasis, and poor prognosis. Treatment protocols are not well-established. To understand this condition more precisely, we performed a retrospective review of eight cases of PMME diagnosed at the...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01111.x

    authors： Yu H,Huang XY,Li Y,Xie X,Zhou JL,Zhang LJ,Fu JH,Wang X

    更新日期：2011-02-01 00:00:00

  • Influence of splenectomy on perioperative morbidity and long-term survival after esophagectomy in patients with esophageal carcinoma.

    abstract：:The aim of this study was to determine the influence of splenectomy on perioperative morbidity and mortality, as well as on the long-term survival after esophageal resection for carcinoma of the esophagus. From September 1985 to July 2003, 404 patients underwent surgery for esophageal carcinoma in our institution. Spl...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2005.00512.x

    authors： Gockel I,Kneist W,Junginger T

    更新日期：2005-01-01 00:00:00

  • ERK1/2 signaling pathway in mast cell activation-induced sensitization of esophageal nodose C-fiber neurons.

    abstract：:Sensitization of esophageal nociceptive afferents by inflammatory mediators plays an important role in esophageal inflammatory nociception. Our previous studies demonstrated that esophageal mast cell activation increases the excitability of esophageal nodose C-fibers. But the intracellular mechanism of this sensitizat...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01127.x

    authors： Gao G,Ouyang A,Kaufman MP,Yu S

    更新日期：2011-04-01 00:00:00

  • Outcome of floppy Nissen fundoplication with intraoperative manometry to treat sliding hiatal hernia.

    abstract：:The aim of this study was to evaluate the effectiveness of floppy Nissen fundoplication with intraoperative esophageal manometry. Between February 1992 and July 2004, there were 102 patients with sliding hiatal hernia undergoing transabdominal Nissen fundoplication. They were divided into three groups: 27 patients wer...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00777.x

    authors： Lei Y,Li JY,Jiang J,Wang J,Zhang QY,Wang TY,Krasna MJ

    更新日期：2008-01-01 00:00:00

  • Health-related quality of life in long-term survivors after high-dose chemoradiotherapy followed by surgery in esophageal cancer.

    abstract：:Curative treatment of esophageal cancer with definitive or preoperative high-dose chemoradiotherapy inflicts a major strain on the patients with potentially severe physical, emotional, and social consequences. The aim of this study was to assess various aspects of quality of life and fatigue in long-term survivors fol...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01104.x

    authors： Hurmuzlu M,Aarstad HJ,Aarstad AK,Hjermstad MJ,Viste A

    更新日期：2011-01-01 00:00:00

  • Distal esophagus is the most commonly involved site for strictures in patients with eosinophilic esophagitis.

    abstract：:While strictures are common in eosinophilic esophagitis (EoE), there are few data on stricture distribution and characteristics. Our primary aim was to characterize strictures by location in the esophagus in EoE and associated clinical, endoscopic, and histologic features. This was a retrospective study from the UNC E...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doz088

    authors： Eluri S,Tappata M,Huang KZ,Koutlas NT,Robey BS,Fan C,Reed CC,Shaheen NJ,Dellon ES

    更新日期：2020-03-05 00:00:00

  • Feasibility of endoscopic mucosal resection as salvage treatment for patients with local failure after definitive chemoradiotherapy for stage IB, II, and III esophageal squamous cell cancer.

    abstract：:Local failure after definitive chemoradiotherapy (CRT) for stage IB, II, and III esophageal cancer is one of the causes of poor outcome. Endoscopic mucosal resection (EMR) is an effective treatment for superficial esophageal cancer. However, its feasibility as a salvage treatment for local recurrent or residual tumors...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/dote.12037

    authors： Makazu M,Kato K,Takisawa H,Yoshinaga S,Oda I,Saito Y,Mayahara H,Ito Y,Itami J,Hamaguchi T,Yamada Y,Shimada Y

    更新日期：2014-01-01 00:00:00

  • Laparoscopic inversion esophagectomy: simplifying a daunting operation.

    abstract：:Minimally invasive esophageal resection is a technically demanding procedure that may reduce patient morbidity and improve convalescence when compared with the open approach. Despite these proposed advantages, the minimally invasive approach has not been widely embraced and is routinely performed in only a few special...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2004.00383.x

    authors： Jobe BA,Reavis KM,Davis JJ,Hunter JG

    更新日期：2004-01-01 00:00:00

  • The inaccuracy of ICD-9-CM Code 530.2 for identifying patients with Barrett's esophagus.

    abstract：:Barrett's esophagus (BE) is a chronic complication associated with gastroesophageal reflux disease. The ICD-9-CM code used for BE, 530.2, is also used for patients with 'ulcer of the esophagus.' We aimed to determine if the ICD-9-CM code of 530.2 is reliable for identifying cases of Barrett's esophagus within database...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1442-2050.2007.00800.x

    authors： Jacobson BC,Gerson LB

    更新日期：2008-01-01 00:00:00

  • Clinical benefits of a swallowing intervention for esophageal cancer patients after esophagectomy.

    abstract：:Dysphagia after esophagectomy is the main cause of a prolonged postoperative stay. The present study investigated the effects of a swallowing intervention led by a speech-language-hearing therapist (SLHT) on postoperative dysphagia. We enrolled 276 consecutive esophageal cancer patients who underwent esophagectomy and...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doaa094

    authors： Takatsu J,Higaki E,Hosoi T,Yoshida M,Yamamoto M,Abe T,Shimizu Y

    更新日期：2020-10-29 00:00:00

  • Fas ligand and Fas receptor are coexpressed in normal human esophageal epithelium: a potential mechanism of apoptotic epithelial turnover.

    abstract：:Fas (CD95/Apo-1) receptor (FasR) is a cell-surface receptor that mediates apoptotic cell death upon triggering by Fas ligand (FasL). We sought to determine whether normal human esophageal epithelial cells express FasL and/or FasR and whether their localization is consistent with a role in the turnover of normal esopha...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1046/j.1442-2050.1999.00032.x

    authors： Bennett MW,O'Connell J,O'Sullivan GC,Roche D,Brady C,Collins JK,Shanahan F

    更新日期：1999-01-01 00:00:00

  • The natural history of gastro-esophageal reflux disease: a comprehensive review.

    abstract：:Gastroesophageal reflux disease (GERD) is a common disorder of the upper gastrointestinal tract which is typically characterized by heartburn and acid regurgitation. These symptoms are widespread in the community and range from 2.5% to more than 25%. Economic analyses showed an increase in direct and indirect costs re...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/dote.12511

    authors： Savarino E,de Bortoli N,De Cassan C,Della Coletta M,Bartolo O,Furnari M,Ottonello A,Marabotto E,Bodini G,Savarino V

    更新日期：2017-02-01 00:00:00

  • Risk factors for surgical site infection after surgery for esophageal perforation.

    abstract：:Esophageal perforations carry a high potential for morbidity and mortality. The prognosis depends on rapid and precise diagnosis and management. Surgical site infections (SSIs) are very common following the surgical treatment of esophageal lesions. We aimed identify significant risk factors for SSI after surgery for e...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00779.x

    authors： Breigeiron R,de Souza HP,Sidou JP

    更新日期：2008-01-01 00:00:00

  • FA01.02: THE EFFECT OF POSTOPERATIVE COMPLICATIONS AFTER MIE ON LONG-TERM SURVIVAL: A RETROSPECTIVE, MULTI-CENTER COHORT STUDY.

    abstract：Background:Esophagectomy has a high incidence of postoperative morbidity. Complications lead to a decreased short-term survival, however the influence of those complications on long-term survival is still unclear. Most of the performed studies are small, single center cohort series with inconclusive or conflicting resu...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,多中心研究

    doi：10.1093/dote/doy089.FA01.02

    authors： Fransen L,Berkelmans G,Asti E,Van Berge Henegouwen M,Berlth F,Bonavina L,Brown A,Bruns C,Gisbertz S,Grimminger P,Gutschow C,Hölscher A,Kauppi J,Lagarde SM,Mercer S,Moons J,Nafteux P,Nilsson M,Palazzo F,Pattyn P,Ph

    更新日期：2018-09-01 00:00:00

  • Association of preoperative inflammation-based prognostic score with survival in patients undergoing salvage esophagectomy.

    abstract：:Salvage esophagectomy (SALV) is potentially beneficial for patients with residual or relapsed esophageal carcinoma after definitive chemoradiotherapy (dCRT), although preoperatively identifying good candidates for SALV remains difficult. We investigated the prognostic impacts of inflammatory and nutritional status in ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doy066

    authors： Sugawara K,Mori K,Yagi K,Aikou S,Uemura Y,Yamashita H,Seto Y

    更新日期：2019-04-01 00:00:00

  • Can the rat be used as a valid model of human esophageal adenocarcinoma?

    abstract：:Animal models of Barrett's metaplasia and esophageal adenocarcinoma are important to further characterize the disease and test potential therapies. This paper reviews the development of the surgical model of esophageal adenocarcinoma in the rat and considers whether this model provides a biologically accurate represen...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01228.x

    authors： Hindmarsh A,Belshaw N,Mehta S,Johnson IT,Rhodes M

    更新日期：2012-02-01 00:00:00

  • Comparison of the prognostic value of the 6th and 7th editions of the Union for International Cancer Control TNM staging system in patients with lower esophageal cancer undergoing neoadjuvant chemotherapy followed by surgery.

    abstract：:Carcinoma of the esophagus is classified according to the Union for International Cancer Control (UICC) TNM staging system. The 7th edition of the UICC TNM staging system was published in 2009. This is the first study to compare the prognostic value of the TNM 6th and 7th editions in patients with esophageal carcinoma...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2012.01350.x

    authors： Mehta SP,Jose P,Mirza A,Pritchard SA,Hayden JD,Grabsch HI

    更新日期：2013-02-01 00:00:00

  • End-stage achalasia.

    abstract：:Despite symptom improvement offered to achalasia patients by either pneumatic dilation or surgical myotomy, 10% to 15% of those so treated will present progressive deterioration of their esophageal function and up to 5% may eventually require an esophagectomy. The natural evolution of achalasia to its end stage as wel...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/j.1442-2050.2010.01157.x

    authors： Duranceau A,Liberman M,Martin J,Ferraro P

    更新日期：2012-05-01 00:00:00