Abstract:
:Regular exercise has the capability of decreasing the incidence and progress of certain cancers. Murine sarcoma, (S-180) cells were transplanted to control (TC), exercise trained (10 week, 1 hour day, 5 times/ week) mice, which had the swimming training terminated at the time of transplantation (ETT), and also to a group of mice that continued to exercise during tumor bearing (ETC). Continuous exercise decreased the size of tumor by about 50%. The accumulation of reactive carbonyl groups (RCD), were not significantly different for any group. The oxidative modification of proteins in the liver of the animals decreased in the exercise- trained non-tumor bearing group compared with control or tumor-bearing groups. No significant alteration was detected in the level of mutant p53. The data indicate that regular exercise retards the development of sarcoma solid tumors and it seems unlikely that massive uncompensated oxidative stress takes place in the tumor. Key pointsRegular exercise has a capability to reduce the inci-dence and progress of certain cancers.Free radicals could act as a promoters and suppres-sors of cancers.Exercise can suppress the development of Sarcoma, but the underlying mechanisms are not known.
journal_name
J Sports Sci Medjournal_title
Journal of sports science & medicineauthors
Sasvari M,Taylor AW,Gaal D,Radak Zsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
93-6issue
1issn
1303-2968journal_volume
10pub_type
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journal_title:Journal of sports science & medicine
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journal_title:Journal of sports science & medicine
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journal_title:Journal of sports science & medicine
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journal_title:Journal of sports science & medicine
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journal_title:Journal of sports science & medicine
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