当前位置： SCI文献检索 > DISEASES OF THE ESOPHAGUS期刊下所有文献 > Translational research on esophageal adenocarcinoma: from cell line to clinic.

Translational research on esophageal adenocarcinoma: from cell line to clinic.

Abstract：

:Human esophageal adenocarcinoma (EAC) cell lines have made a substantial contribution to elucidating mechanisms of carcinogenesis and drug discovery. Model research on EAC relies almost entirely on a relatively small set of established tumor cell lines because appropriate animal models are lacking. Nowadays, more than 20% of all fundamental translational research studies regarding EAC are partially or entirely based on these cell lines. The ready availability of these cell lines to investigators worldwide have resulted in more than 250 publications, including many examples of important biomedical discoveries. The high genomic similarities (but certainly not completely identical) between the EAC cell lines and their original tumors provide rational for their use. Recently, in a collaborative effort all available EAC cell lines have been verified resulting in the establishment of a reliable panel of 10 EAC cell lines. It could be expected that the value of these cell lines increases as unlimited source of tumor material because new biomedical techniques require more tumor cells and the supply of viable tumor cells is diminishing because of neoadjuvant chemo(radio)therapy of patients with EAC. Here, we review the history of the EAC cell lines and their utility in translational research and biomedical discovery.

journal_name

Dis Esophagus

journal_title

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

authors

Boonstra JJ,Tilanus HW,Dinjens WN

doi

10.1111/dote.12095

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

90-6

issue

1

eissn

1120-8694

issn

1442-2050

journal_volume

28

pub_type

杂志文章,评审

相关文献

DISEASES OF THE ESOPHAGUS文献大全
  • Adenocarcinoma in a gastric tube after esophagectomy for esophageal carcinoma.

    abstract：:The development of an adenocarcinoma in a reconstructed tube after subtotal esophagectomy for esophagus squamous cell carcinoma (ESCC) is uncommon and has been reported in articles from the Japanese medical community. We report three cases of patients who had this clinical presentation. We suggest an approach to posto...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1046/j.1442-2050.2003.00317.x

    authors： Lamblin A,Mariette C,Triboulet JP

    更新日期：2003-01-01 00:00:00

  • Outcome and risk factors assessment for adverse events in advanced esophageal cancer patients after self-expanding metal stents placement.

    abstract：:Self-expanding metal stents (SEMS) are the treatment of choice for advanced esophageal cancers. Literature is scarce on risk factors predictors for adverse events after SEMS placement. Assess risk factors for adverse events after SEMS placement in advanced esophageal cancer and evaluate survival after SEMS placement. ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/dote.12467

    authors： Rodrigues-Pinto E,Pereira P,Coelho R,Andrade P,Ribeiro A,Lopes S,Moutinho-Ribeiro P,Macedo G

    更新日期：2017-02-01 00:00:00

  • Laparoscopic transhiatal resection of epiphrenic diverticulum.

    abstract：:Our experience with videolaparoscopic operations for hiatus hernia and achalasia, which have almost replaced classical procedures, enabled us to use the same technique for other interventions in the distal third of the thoracic esophagus. Thus, we were able to treat epiphrenic diverticulum using a minimally invasive a...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1046/j.1442-2050.2002.00275.x

    authors： Neoral C,Aujeský R,Bohanes T,Klein J,Král V

    更新日期：2002-01-01 00:00:00

  • Comparison of the effect of a cornstarch thickened formula and strengthened regular formula on regurgitation, gastric emptying and weight gain in infantile regurgitation.

    abstract：:The purpose of this study was to evaluate the efficacy of a specially selected cornstarch-supplemented formula on clinical symptoms, gastric emptying and weight gain in infants with regurgitation. We performed a prospective randomised trial evaluating the therapeutic efficacy of two different formula feedings (cornsta...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2007.00662.x

    authors： Chao HC,Vandenplas Y

    更新日期：2007-01-01 00:00:00

  • Primary malignant melanoma of the esophagus: a study of clinical features, pathology, management and prognosis.

    abstract：:Primary malignant melanoma of the esophagus (PMME) is a rare disease that is characterized by aggressive invasion, early metastasis, and poor prognosis. Treatment protocols are not well-established. To understand this condition more precisely, we performed a retrospective review of eight cases of PMME diagnosed at the...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01111.x

    authors： Yu H,Huang XY,Li Y,Xie X,Zhou JL,Zhang LJ,Fu JH,Wang X

    更新日期：2011-02-01 00:00:00

  • Can the rat be used as a valid model of human esophageal adenocarcinoma?

    abstract：:Animal models of Barrett's metaplasia and esophageal adenocarcinoma are important to further characterize the disease and test potential therapies. This paper reviews the development of the surgical model of esophageal adenocarcinoma in the rat and considers whether this model provides a biologically accurate represen...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2011.01228.x

    authors： Hindmarsh A,Belshaw N,Mehta S,Johnson IT,Rhodes M

    更新日期：2012-02-01 00:00:00

  • Telomerase activity and survival of late-stage South African esophageal carcinoma patients.

    abstract：:Squamous cell carcinoma of the esophagus is a cancer with a high incidence in South Africa. We have investigated the prognostic value of telomerase activity in tumors as well as nearby normal tissue. Biopsies from 98 patients (71 men and 27 women) were analyzed using an adaptation of the TRAP assay. We found all tumor...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2004.00417.x

    authors： van den Heever WM,Pretorius GH,Smit SJ

    更新日期：2004-01-01 00:00:00

  • Primary esophageal mucosa-associated lymphoid tissue lymphoma diagnosed by using stacked forceps biopsy.

    abstract：:Non-Hodgkin lymphoma involving the esophagus is very rare. Only a few cases have been reported in the English literature to date, and it accounts for less than 1% of all cases of gastrointestinal lymphoma. As this malignancy manifests as a submucosal tumor, pathological diagnosis by using a simple endoscopic biopsy al...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/dote.12309

    authors： Lee DS,Ahn YC,Eom DW,Lee SJ

    更新日期：2016-10-01 00:00:00

  • Long-term pharyngeal dysphagia after esophagectomy for esophageal cancer-an investigation using videofluoroscopic swallow studies.

    abstract：:Dysphagia is a common symptom of esophageal cancer (EC). Esophagectomy should relieve the presenting dysphagia as the mechanical obstruction caused by the tumor is removed. However, the new onset oropharyngeal dysphagia develops after esophagectomy and the deficit may persist increasing the risk of aspiration pneumoni...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doy068

    authors： Yuen MTY,Tsang RK,Wong IYH,Chan DKK,Chan FSY,Law SYK

    更新日期：2019-01-01 00:00:00

  • Trimodality therapy and definitive chemoradiotherapy for esophageal cancer: a single-center experience and review of the literature.

    abstract：:In the UK, the standard of care for esophageal cancer has generally combined surgery with neoadjuvant chemotherapy, with definitive chemoradiotherapy (dCRT) being reserved for certain subgroups. Chemoradiotherapy followed by surgery (trimodality therapy) has not been widely adopted. The outcomes of patients undergoing...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,评审

    doi：10.1111/dote.12242

    authors： Hategan M,Cook N,Prewett S,Hindmarsh A,Qian W,Gilligan D

    更新日期：2015-10-01 00:00:00

  • Intraoperative recurrent laryngeal nerve monitoring: a useful method for patients with esophageal cancer.

    abstract：:It is well accepted that recurrent laryngeal nerve paralysis is a severe complication of esophagectomy or lymphadenectomy performed adjacent to the recurrent laryngeal nerves. Herein, determination of the effectiveness of implementing continuous recurrent laryngeal nerve monitoring to reduce the incidence of recurrent...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2012.01414.x

    authors： Zhong D,Zhou Y,Li Y,Wang Y,Zhou W,Cheng Q,Chen L,Zhao J,Li X,Yan X

    更新日期：2014-07-01 00:00:00

  • Benign esophagorespiratory fistula: a case series and a novel technique of definitive management.

    abstract：:Benign esophagorespiratory fistula is a relatively rare condition in adults that poses a technical challenge to manage. This case series describes our experience in the treatment of benign esophagorespiratory fistula in 12 adults. A retrospective review of case records of 12 patients with benign esophagorespiratory fi...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2012.01347.x

    authors： Deshpande G,Samarasam I,Banerjee S,Gnanamuthu RB,Chandran S,Mathew G

    更新日期：2013-02-01 00:00:00

  • Sub-diaphragmatic fascia: role in the recurrence of hiatal hernias.

    abstract：:One of the most common causes of a failed Nissen fundoplication is disruption of the crural repair. We investigated the thickness of the subdiaphragmatic fascia overlying the right and left limb of the right crus in cadavers to determine any difference. Sub-diaphragmatic fascia specimens were obtained from three sites...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2006.00554.x

    authors： Tierney BJ,Iqbal A,Awad Z,Penka W,Filipi CJ,Mittal SK

    更新日期：2006-01-01 00:00:00

  • Endoscopic bougienage of benign anastomotic strictures in patients after esophageal resection: the effect of the extent of stricture on bougienage results.

    abstract：SUMMARY:The aim of our retrospective study was to determine the incidence of benign anastomotic strictures (BAS) in patients after esophageal resection and to examine the influence of the extent of BAS on the results of bougienage therapy. From January 2001 to July 2006, 79 patients at risk of BAS development were incl...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2008.00819.x

    authors： Marjanovic G,Schrag HJ,Fischer E,Hopt UT,Fischer A

    更新日期：2008-01-01 00:00:00

  • Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis.

    abstract：:To find new genes involved in esophageal squamous cell carcinogenesis, we constructed custom cDNA arrays and used the arrays to compare gene expression profiles of 12 matched normal and malignant esophageal samples including seven superficial cancer tissues. The arrays represented nearly 4000 genes, including 1728 tha...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2005.00432.x

    authors： Makino H,Tajiri T,Miyashita M,Sasajima K,Anbazhagan R,Johnston J,Gabrielson E

    更新日期：2005-01-01 00:00:00

  • Concurrent chemoradiation alone with curative intent for limited-disease small-cell esophageal cancer in nine Japanese patients.

    abstract：:Small-cell carcinoma of the esophagus is a rare and aggressive tumor with early widespread dissemination. In this retrospective study, we report clinical outcomes of limited-disease small-cell carcinoma of the esophagus from the analysis of nine patients. Between 2003 and 2006, nine consecutive patients with small-cel...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2008.00863.x

    authors： Yamashita H,Nakagawa K,Asari T,Murakami N,Igaki H,Okuma K,Ohtomo K

    更新日期：2009-01-01 00:00:00

  • Distal esophagus is the most commonly involved site for strictures in patients with eosinophilic esophagitis.

    abstract：:While strictures are common in eosinophilic esophagitis (EoE), there are few data on stricture distribution and characteristics. Our primary aim was to characterize strictures by location in the esophagus in EoE and associated clinical, endoscopic, and histologic features. This was a retrospective study from the UNC E...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doz088

    authors： Eluri S,Tappata M,Huang KZ,Koutlas NT,Robey BS,Fan C,Reed CC,Shaheen NJ,Dellon ES

    更新日期：2020-03-05 00:00:00

  • Same-day discharge in benign esophageal surgery: a prospective cohort study.

    abstract：:Day-case esophageal surgery has been demonstrated to be safe in small prospective cohorts and only for laparoscopic fundoplication. The aims of this study are to assess the feasibility and safety of a large series of esophageal day-case surgeries, including laparoscopic Nissen fundoplication (LNF), Zenker diverticulec...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/dow036

    authors： Desbeaux A,Gronnier C,Piessen G,Vanderbeken M,Ruolt N,Triboulet JP,Mariette C

    更新日期：2017-04-01 00:00:00

  • The overall metastatic rate in early esophageal adenocarcinoma: long-time follow-up of surgically treated patients.

    abstract：:The overall metastatic potential of surgically treated early esophageal adenocarcinoma has not been studied in detail. This paper therefore assessed lymph node metastases at surgery, loco regional and distant metastases, in order to assess the metastatic potential of early esophageal adenocarcinoma. Two hundred and se...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/doy127

    authors： Oetzmann von Sochaczewski C,Haist T,Pauthner M,Mann M,Fisseler-Eckhoff A,Braun S,Ell C,Lorenz D

    更新日期：2019-11-13 00:00:00

  • Evaluation of clinical significance of 18F-fluorodeoxyglucose positron emission tomography in superficial squamous cell carcinomas of the thoracic esophagus.

    abstract：:(18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used for pre-treatment staging and evaluation of response to pre-operative therapy in advanced thoracic esophageal cancers. To evaluate the clinical significance of PET diagnosis of superficial thoracic esophageal cancers, FDG-PET was conducted preop...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00743.x

    authors： Miyata H,Doki Y,Yasuda T,Yamasaki M,Higuchi I,Makari Y,Matsuyama J,Hirao T,Takiguchi S,Fujiwara Y,Monden M

    更新日期：2008-01-01 00:00:00

  • Omission of preoperative esophageal manometry does not alter operative approach or postoperative dysphagia following laparoscopic paraesophageal hernia repair.

    abstract：:Routine esophageal manometry for surgical planning before laparoscopic paraesophageal hernia (PEH) has been advocated in an effort to reduce the likelihood of postoperative dysphagia. The purpose of this study is to investigate whether omitting routine preoperative esophageal manometry is associated with a change in t...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/dox044

    authors： Zevin B,Jones EL,Martin Del Campo SE,Perry KA

    更新日期：2017-07-01 00:00:00

  • Risk of malignant progression in Barrett's esophagus indefinite for dysplasia.

    abstract：:Barrett's esophagus is a well-recognized risk factor for esophageal adenocarcinoma. The natural history of Barrett's esophagus classified as ‘indefinite for dysplasia’ (IND) is poorly characterized. The aim of this study is to characterize the natural history of IND by determining the rate of neoplastic progression an...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/dow025

    authors： Ma M,Shroff S,Feldman M,DeMarshall M,Price C,Tierney A,Falk GW

    更新日期：2017-03-01 00:00:00

  • Neoadjuvant chemoradiotherapy followed by esophagectomy for initially resectable squamous cell carcinoma of the esophagus with multiple lymph node metastasis.

    abstract：:Neoadjuvant chemoradiotherapy (CRT) was expected to improve surgical curability and prognosis for advanced esophageal cancer. However, the clinical efficacy of neoadjuvant CRT followed by esophagectomy with three-field lymphadenectomy (3FL) for initially resectable esophageal squamous cell carcinoma (SCC) remains uncl...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2005.00521.x

    authors： Nabeya Y,Ochiai T,Matsubara H,Okazumi S,Shiratori T,Shuto K,Aoki T,Miyazaki S,Gunji Y,Uno T,Ito H,Shimada H

    更新日期：2005-01-01 00:00:00

  • Characterization of tissue chromogranin A (CgA) immunostaining and clinicohistopathological changes for the 125 Chinese patients with primary small cell carcinoma of the esophagus.

    abstract：:The rarity of primary small cell carcinoma of the esophagus (PSCE) has limited the clinical feature and survival analysis with large sample size. Tissue chromogranin A (CgA) protein expression has been reported to be a useful biomarker for diagnosing PSCE. Interestingly, recent studies have indicated tissue CgA as a s...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1093/dote/dox041

    authors： Ku JW,Zhang DY,Song X,Li XM,Zhao XK,Lv S,Hu SJ,Cheng R,Zhou FY,Wu HF,Wang LD

    更新日期：2017-08-01 00:00:00

  • Population-based assessment of heartburn in urban Black Americans.

    abstract：:Prevalence data for heartburn in the urban Black American community is lacking. In order to estimate prevalence for this community, we analyzed data from an ongoing cohort study in progress at our hospital. Comprehensive interviews allowed for exploration of factors associated with heartburn. Complex, stratified sampl...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/dote.12007

    authors： Friedenberg FK,Makipour K,Palit A,Shah S,Vanar V,Richter JE

    更新日期：2013-08-01 00:00:00

  • Liver metastases from esophageal carcinoma: is there a role for surgical resection?

    abstract：:Esophageal cancer recurrence rates after esophagectomy are high, and locally recurrent or distant metastatic disease has poor prognosis. Management is limited to palliative chemotherapy and symptomatic interventions. We report our experience of four patients who have undergone successful liver resection for metastases...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/dote.12233

    authors： Huddy JR,Thomas RL,Worthington TR,Karanjia ND

    更新日期：2015-07-01 00:00:00

  • Estrogen and progesterone receptors in esophageal carcinoma.

    abstract：:Information is sparse and contradictory in the literature regarding the role of estrogen receptor (ER) and progesterone receptor (PR) in esophageal carcinoma. This study was conducted over a period of 18 months from September 2004 with the primary aim of determining the PR, ER alpha (ERalpha) and ER beta (ERbeta) stat...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2007.00767.x

    authors： Kalayarasan R,Ananthakrishnan N,Kate V,Basu D

    更新日期：2008-01-01 00:00:00

  • Expression of the putative stem cell marker Musashi-1 in Barrett's esophagus and esophageal adenocarcinoma.

    abstract：:The cancer stem cell theory states that cancers contain tumor-forming cells that have the ability to self-renew as well as give rise to cells that differentiate. Cancer stem cells have been identified in several solid tumors, but stem cells in normal human esophagus or in Barrett's esophagus or adenocarcinoma have not...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/j.1442-2050.2010.01061.x

    authors： Bobryshev YV,Freeman AK,Botelho NK,Tran D,Levert-Mignon AJ,Lord RV

    更新日期：2010-09-01 00:00:00

  • Prospective randomized controlled study on the effects of perioperative administration of a neutrophil elastase inhibitor to patients undergoing video-assisted thoracoscopic surgery for thoracic esophageal cancer.

    abstract：:Sivelestat sodium hydrate (Ono Pharmaceutical Co., Osaka, Japan) is a selective inhibitor of neutrophil elastase (NE) and is effective in reducing acute lung injury associated with systemic inflammatory response syndrome (SIRS). We conducted a prospective randomized controlled study to investigate the efficacy of peri...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1442-2050.2009.01010.x

    authors： Kawahara Y,Ninomiya I,Fujimura T,Funaki H,Nakagawara H,Takamura H,Oyama K,Tajima H,Fushida S,Inaba H,Kayahara M

    更新日期：2010-05-01 00:00:00

  • Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus.

    abstract：BACKGROUND AND AIMS:There has been a recent increase in the incidence of oropharyngeal cancer (OPC) associated with high-risk human papilloma virus (HPV) infection. We investigated the incidence of esophageal papilloma and the presence of high-risk HPV infection. METHODS:This is a cross-sectional study conducted at a ...

    journal_title：Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type： 杂志文章

    doi：10.1111/dote.12475

    authors： Pantham G,Ganesan S,Einstadter D,Jin G,Weinberg A,Fass R

    更新日期：2017-01-01 00:00:00