Abstract:
:In recent years, the incidence of lipid metabolism disorders in adolescents has gradually increased, and the effects of DEHP on lipid metabolism have received widespread attention. In this study, 463 adolescents aged 16-19 years were enrolled as subjects. This study analyzed the associations between the urinary levels of DEHP metabolites (MEHP, MEOHP, MEHHP, MECPP, MCMHP, and ∑DEHP) and BMI, WHR, WtHR, VAI, LAP, the plasma levels of lipids (TC, TG, HDL-C, and LDL-C), and the peripheral blood leukocyte mRNA levels of SREBP-2, SR-BI, LDLR, and NR1H3. Animal experiments were performed to confirm and expand findings. Wistar rats were administered DEHP at 0, 5, 50, and 500 mg/kg/d for 8 weeks. The serum and liver levels of TC, TG, HDL-C, and LDL-C, and the liver mRNA and protein levels of SREBP-2, SR-BI, LDLR, and NR1H3 were measured. The results showed that WHR, VAI, and LAP were significantly positively associated with the urinary levels of MECPP and ∑DEHP; the plasma HDL-C level was significantly negatively associated with the levels of MECPP, MCMHP and ∑DEHP; the peripheral blood leukocyte mRNA levels of SREBP-2, NR1H3, and LDLR were significantly positively correlated with the MCMHP level; and the SR-BI mRNA level was significantly positively correlated with the levels of MECPP and MCMHP in adolescents. Moreover, the results of animal experiments showed that DEHP exposure significantly increased the serum levels of TC, HDL-C, and LDL-C in 500 mg/kg/d group, as well as the liver levels of TC and HDL-C, up-regulated SREBP-2 mRNA and protein expression in 50 and 500 mg/kg/d groups. DEHP exposure significantly down-regulated SR-BI and NR1H3 protein expression in the liver of the 500 mg/kg/d group rats. Our findings indicate that DEHP exposure can affect lipid metabolism in adolescents by regulating the expression of lipid metabolism-related genes.
journal_name
Environ Pollutjournal_title
Environmental pollution (Barking, Essex : 1987)authors
Ding S,Qi W,Xu Q,Zhao T,Li X,Yin J,Zhang R,Huo C,Zhou L,Ye Ldoi
10.1016/j.envpol.2021.117570keywords:
["Cholesterol metabolism","DEHP","Environmental endocrine disruptors","Lipid metabolism"]subject
Has Abstractpub_date
2021-10-01 00:00:00pages
117570eissn
0269-7491issn
1873-6424pii
S0269-7491(21)01152-0journal_volume
286pub_type
杂志文章相关文献
文献大全abstract::Immunoglobulins G (lgG) specific for benzo[a]pyrene-DNA adducts were elicited in Swiss mice by repeated subcutaneous injections of a high molecular weight benzo[a]pyrene-DNA conjugate-adjuvant mix. The immunization procedure resulted in the production of specific antibodies against adducted benzo[a]pyrene B[a]P in all...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00097-x
更新日期:2001-01-01 00:00:00
abstract::Immunoglobulins G (lgG) specific for benzo[a]pyrene-DNA adducts were elicited in Swiss mice by repeated subcutaneous injections of a high molecular weight benzo[a]pyrene-DNA conjugate-adjuvant mix. The immunization procedure resulted in the production of specific antibodies against adducted benzo[a]pyrene B[a]P in all...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(99)00329-2
更新日期:2001-01-01 00:00:00
abstract::Immunoglobulins G (lgG) specific for benzo[a]pyrene-DNA adducts were elicited in Swiss mice by repeated subcutaneous injections of a high molecular weight benzo[a]pyrene-DNA conjugate-adjuvant mix. The immunization procedure resulted in the production of specific antibodies against adducted benzo[a]pyrene B[a]P in all...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00032-4
更新日期:2001-01-01 00:00:00
abstract::Immunoglobulins G (lgG) specific for benzo[a]pyrene-DNA adducts were elicited in Swiss mice by repeated subcutaneous injections of a high molecular weight benzo[a]pyrene-DNA conjugate-adjuvant mix. The immunization procedure resulted in the production of specific antibodies against adducted benzo[a]pyrene B[a]P in all...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00075-0
更新日期:2001-01-01 00:00:00
abstract::Immunoglobulins G (lgG) specific for benzo[a]pyrene-DNA adducts were elicited in Swiss mice by repeated subcutaneous injections of a high molecular weight benzo[a]pyrene-DNA conjugate-adjuvant mix. The immunization procedure resulted in the production of specific antibodies against adducted benzo[a]pyrene B[a]P in all...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00067-1
更新日期:2001-01-01 00:00:00
abstract::Immunoglobulins G (lgG) specific for benzo[a]pyrene-DNA adducts were elicited in Swiss mice by repeated subcutaneous injections of a high molecular weight benzo[a]pyrene-DNA conjugate-adjuvant mix. The immunization procedure resulted in the production of specific antibodies against adducted benzo[a]pyrene B[a]P in all...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00091-9
更新日期:2001-01-01 00:00:00
abstract::Immunoglobulins G (lgG) specific for benzo[a]pyrene-DNA adducts were elicited in Swiss mice by repeated subcutaneous injections of a high molecular weight benzo[a]pyrene-DNA conjugate-adjuvant mix. The immunization procedure resulted in the production of specific antibodies against adducted benzo[a]pyrene B[a]P in all...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00080-4
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The presence of diabetes mellitus adversely affects the late survival of patients undergoing coronary artery bypass grafting (CABG). The purpose of this study is to clarify the role of diabetic nephropathy on outcomes of a group of patients on chronic hemodialysis undergoing CABG. METHODS:Between April 1984...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00120-2
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:The presence of diabetes mellitus adversely affects the late survival of patients undergoing coronary artery bypass grafting (CABG). The purpose of this study is to clarify the role of diabetic nephropathy on outcomes of a group of patients on chronic hemodialysis undergoing CABG. METHODS:Between April 1984...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00108-1
更新日期:2001-01-01 00:00:00
abstract::There is evidence of similarities and interactions between central opioid and cannabinoid system with reference to drug reinforcement and abuse. Here we demonstrate that repeated injection of heroin produces behavioral sensitization towards administration of the synthetic cannabinoid receptor agonist WIN55212.2 in the...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00137-8
更新日期:2001-01-01 00:00:00
abstract::There is evidence of similarities and interactions between central opioid and cannabinoid system with reference to drug reinforcement and abuse. Here we demonstrate that repeated injection of heroin produces behavioral sensitization towards administration of the synthetic cannabinoid receptor agonist WIN55212.2 in the...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00135-4
更新日期:2001-01-01 00:00:00
abstract::An affinity study between the G protein of the visual photoreceptor, transducin, and eight different non-hydrolyzable GDP analogues is described. Imidodiphosphate derivatives have been shown to exhibit good affinities to transducin. This very important heterotrimeric G protein is shown to be highly restrictive with re...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00160-3
更新日期:2001-01-01 00:00:00
abstract::In view of the tendency toward vascular disease in diabetes mellitus, we studied platelet aggregation in 15 normal, 7 prediabetic, 12 latent, and 20 frankly diabetic subjects. Platelets from latent and frank diabetics showed increased platelet aggregation 4 minutes after adding adenosine 5'-diphosphate (60% verus 29% ...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00167-6
更新日期:2001-01-01 00:00:00
abstract::BACKGROUND/AIMS: Automated image analysis of complex tissues is usually limited by the difficulty of recognizing special structures by computer. The aim of this study was to test the applicability of discriminant and cluster analysis to the interpretation of skin images. METHODS: Digital images from microscopic, derma...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00193-7
更新日期:2001-01-01 00:00:00
abstract::BACKGROUND/AIMS: Automated image analysis of complex tissues is usually limited by the difficulty of recognizing special structures by computer. The aim of this study was to test the applicability of discriminant and cluster analysis to the interpretation of skin images. METHODS: Digital images from microscopic, derma...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00183-4
更新日期:2001-01-01 00:00:00
abstract::Saikosaponin a, a purified ingredient of Chinese herb with known antitumor activity, can inhibit cell growth and DNA synthesis of hepatoma cell line HepG2. Both mRNA and protein of the CDK inhibitor p-16(INK4a) and p-15(INK4b) in HepG2 were greatly induced by saikosaponin a while that of p-21(CIP), p-27(KIP) and other...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00205-0
更新日期:2001-01-01 00:00:00
abstract::Treatment with the 3-hydroxy-3-methylglutaryl coenyzme A reductase inhibitors (or statins) reduces the risk for cardiovascular events across a broad spectrum of patient profiles, as evidenced by both primary prevention and secondary prevention trials. Improved survival by way of reduced deaths from coronary heart dise...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00217-7
更新日期:2001-01-01 00:00:00
abstract::Distribution of glucose transporter (GLUT-1) in the microvascular endothelium of scrapie-infected SJL/J hyperglycemic mice showing clinical signs of scrapie, obesity and reduced glucose tolerance was studied in five brain regions: cerebral cortex, hippocampus, thalamus, cerebellum and olfactory bulb. Uninfected normog...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00240-2
更新日期:2001-01-01 00:00:00
abstract::Distribution of glucose transporter (GLUT-1) in the microvascular endothelium of scrapie-infected SJL/J hyperglycemic mice showing clinical signs of scrapie, obesity and reduced glucose tolerance was studied in five brain regions: cerebral cortex, hippocampus, thalamus, cerebellum and olfactory bulb. Uninfected normog...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(00)00226-8
更新日期:2001-01-01 00:00:00
abstract::Recently, we identified four kinetically distinct voltage-gated K(+) currents, I(Af), I(As), I(K), and I(SS), in rat superior cervical ganglion (SCG) neurons and demonstrated that I(Af) and I(As) are differentially expressed in type I (I(Af), I(K), I(SS)), type II (I(Af), I(As), I(K), I(SS)), and type III (I(K), I(SS)...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00091-4
更新日期:2001-01-01 00:00:00
abstract::The results of previous radiation experiments, which indicated that the centriole serves as a control center for bull sperm motility, appear to be in conflict with experiments showing that the bull sperm flagellum is an autonomous oscillator. To resolve this conflict experiments were conducted to calibrate absolutely ...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00110-5
更新日期:2001-01-01 00:00:00
abstract::The results of previous radiation experiments, which indicated that the centriole serves as a control center for bull sperm motility, appear to be in conflict with experiments showing that the bull sperm flagellum is an autonomous oscillator. To resolve this conflict experiments were conducted to calibrate absolutely ...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00099-9
更新日期:2001-01-01 00:00:00
abstract::A protein structure model generally needs to be evaluated to assess whether or not it has the correct fold. To improve fold assessment, four types of a residue-level statistical potential were optimized, including distance-dependent, contact, Phi/Psi dihedral angle, and accessible surface statistical potentials. Appro...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00232-9
更新日期:2001-01-01 00:00:00
abstract::1. Utilization of 5mM-glucose by slices of lactating mammary gland was decreased 33% on addition of acetoacetate (2mM) to the incubation medium. This inhibition was accompanied by increases in the intracellular concentrations of citrate and glucose 6-phosphate. 2. In the presence of acetoacetates the accumulation of p...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00129-4
更新日期:2002-01-01 00:00:00
abstract::1. Utilization of 5mM-glucose by slices of lactating mammary gland was decreased 33% on addition of acetoacetate (2mM) to the incubation medium. This inhibition was accompanied by increases in the intracellular concentrations of citrate and glucose 6-phosphate. 2. In the presence of acetoacetates the accumulation of p...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00187-7
更新日期:2002-01-01 00:00:00
abstract::Iron overload is a major concern in hepatitis C virus (HCV) infection because excess iron can promote hepatocyte damage by activating iron-mediated lipid peroxidation. This may also facilitate viral replication. The objective of this pilot study was to test the hypothesis that Puerto Rican HCV patients have an altered...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00123-3
更新日期:2002-01-01 00:00:00
abstract::Ground squirrels undergo extreme body temperature fluctuations during hibernation. The effect of low body temperatures on the mammalian circadian system is still under debate. Using implanted temperature loggers, we recorded body temperature patterns in European ground squirrels kept in an enclosure under natural cond...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00211-1
更新日期:2002-01-01 00:00:00
abstract::Ground squirrels undergo extreme body temperature fluctuations during hibernation. The effect of low body temperatures on the mammalian circadian system is still under debate. Using implanted temperature loggers, we recorded body temperature patterns in European ground squirrels kept in an enclosure under natural cond...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00221-4
更新日期:2002-01-01 00:00:00
abstract::It has been demonstrated that the type of dietary fat affects insulin receptors in various tissues in normal humans and animals by altering membrane fluidity. This study compares the effects of n-3 fatty acids from fish oil and n-6 fatty acids from corn oil on red blood cell membrane insulin receptors in normal and hy...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00268-8
更新日期:2002-01-01 00:00:00
abstract::It has been demonstrated that the type of dietary fat affects insulin receptors in various tissues in normal humans and animals by altering membrane fluidity. This study compares the effects of n-3 fatty acids from fish oil and n-6 fatty acids from corn oil on red blood cell membrane insulin receptors in normal and hy...
journal_title:Environmental pollution (Barking, Essex : 1987)
pub_type: 杂志文章
doi:10.1016/s0269-7491(01)00258-5
更新日期:2002-01-01 00:00:00