Abstract:
:Alginic acid and its sodium salt are well-accepted pharmaceutical excipients fulfilling several roles in the development of solid oral dosage forms. Although they have attractive advantages as safety, abundance, relatively low cost and biodegradability, these natural polysaccharides possess a high variability that may limit their use as excipients for tablet formulation. Thus, to obtain robust formulations and high-quality drug products with consistent performance a complete understanding of the structure-property relationship becomes necessary as the structure of alginates affects both, technological and biopharmaceutical properties. This review compiles the compaction studies carried out that relate the structure of alginates to their mechanical and dissolution performances. The different analytical methods used to determine the chemical composition, primary structure and molecular weight distribution, major factors affecting the behavior of alginates in direct compression, are also exposed. Finally, different strategies reported to improve the properties of alginic acid as direct compression excipient are discussed.
journal_name
Carbohydr Polymjournal_title
Carbohydrate polymersauthors
Sanchez-Ballester NM,Bataille B,Soulairol Idoi
10.1016/j.carbpol.2021.118399keywords:
["Alginic acid","Biosourced","Direct compression","Pharmaceutical excipient","Sodium alginate","Tablet formulations"]subject
Has Abstractpub_date
2021-10-15 00:00:00pages
118399eissn
0144-8617issn
1879-1344pii
S0144-8617(21)00786-4journal_volume
270pub_type
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