Abstract：
:Highly simple, sensitive and selective method is developed for the spectrophotometric determination of Metronidazole (MDZ) antibacterial drug either in pure form or in pharmaceutical formulations. This method is based on reduction of potassium permanganate by Metronidazole drug in sodium hydroxide solution to give green manganate ion which recorded at 610 nm. The method produced linear responses in the concentration range 4.28 - 59.91 µg mL-1 with limit of detection (LOD) and limit of quantification (LOQ) 0.21 and 0.69 µg mL-1 for Metronidazole drug respectively. The apparent molar absorptivity is 0.865 × 104 L mol-1 cm-1, Sandell sensitivity is 0.019 µg cm-2 and correlation coefficient is 0.951. The method is highly reproducible and has been applied to a wide variety of pharmaceutical formulations and the results compare favourably with those of official methods.
journal_name
Spectrochim Acta A Mol Biomol Spectroscauthors
Abdel-Kader DA,Hashem EYdoi
10.1016/j.saa.2021.119858keywords:
["Drug","KMnO(4)","Metronidazole","Pharmaceutical formulation","Spectrophotometric analysis"]subject
Has Abstractpub_date
2021-10-05 00:00:00pages
119858eissn
1386-1425issn
1873-3557pii
S1386-1425(21)00434-0journal_volume
259pub_type
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