Genetic and environmental influences in sleep-disordered breathing in older male twins.

Abstract:

STUDY OBJECTIVES:To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins. DESIGN AND SETTING:A biometric genetic study based on data from unattended Edentrace recordings in a sample of elderly male twins. PARTICIPANTS:122 World War II male veteran twin pairs, including 68 monozygotic pairs aged 78.9 (+/- 2.7) years and 54 dizygotic pairs aged 78.4 (+/- 2.4) years. INTERVENTIONS:N/A. MEASUREMENTS AND RESULTS:The average (+/- SD) respiratory disturbance index for this sample was 17.2 +/- 14.5, the average (+/- SD) oxygen desaturation index was 18.8 +/- 16.4, and the average (+/- SD) minimum SaO2 level was 79.6 +/- 8.1%. Intraclass twin-pair correlations for log-transformed respiratory disturbance index were 0.59 in monozygotic pairs and 0.36 in dizygotic pairs. For oxygen desaturation index, intraclass correlations were 0.44 in monozygotic pairs and 0.24 in dizygotic pairs. For minimum SaO2, intraclass correlations were 0.38 and 0.11, respectively. Maximum likelihood estimates of heritability with associated 95% confidence intervals were 37% [22%, 52%] for respiratory disturbance index, 36% [19%, 53%] for oxygen desaturation index, and 10% [0%, 30%] for minimum SaO2. Adjustments of sleep-disordered breathing measures for age, body mass index, and waist and neck circumference had minimal effect on estimates of heritability. CONCLUSIONS:The present data indicate that sleep-disordered breathing, even in old age, is determined, in part, by genetic factors.

journal_name

Sleep

journal_title

Sleep

authors

Carmelli D,Colrain IM,Swan GE,Bliwise DL

doi

10.1093/sleep/27.5.917

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

917-22

issue

5

eissn

0161-8105

issn

1550-9109

journal_volume

27

pub_type

杂志文章

相关文献

SLEEP文献大全
  • Relationship of arousal threshold to sleep stage distribution and subjective estimates of depth and quality of sleep.

    abstract::The relationship of arousal threshold, amounts of various sleep stages, and subjective rating of sleep was studied in two separate experiments involving 7 and 26 young adult subjects, respectively. Electroencephalographic sleep stage data, subjective response data, and arousal threshold data were collected over a seri...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/1.2.161

    authors: Bonnet MH,Johnson LC

    更新日期:1978-01-01 00:00:00

  • Predictive value of clinical features in diagnosing obstructive sleep apnea.

    abstract::We examined the predictive value of history and physical examination in the diagnosis of obstructive sleep apnea (OSA) syndrome. This was achieved by studying a set of 594 patients referred to the sleep clinic because of suspicion of sleep apnea. All patients were asked a set of standard sleep-related questions and al...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:

    authors: Hoffstein V,Szalai JP

    更新日期:1993-02-01 00:00:00

  • Breast cancer patients have progressively impaired sleep-wake activity rhythms during chemotherapy.

    abstract:PURPOSE:Prior cross-sectional studies have shown that cancer patients have sleep-wake activity cycles that show little distinction between daytime and nighttime, a pattern indicative of circadian disruption. This pattern is seen both before and during cancer treatment. Long-term data are needed, however, to assess to w...

    journal_title:Sleep

    pub_type: 临床试验,杂志文章

    doi:10.1093/sleep/32.9.1155

    authors: Savard J,Liu L,Natarajan L,Rissling MB,Neikrug AB,He F,Dimsdale JE,Mills PJ,Parker BA,Sadler GR,Ancoli-Israel S

    更新日期:2009-09-01 00:00:00

  • Sleep, dreaming, and adaptation to a stressful intellectual activity.

    abstract::Sixteen male subjects slept in the laboratory for 4 consecutive nights. Night 1 was an adaptation night and night 2 was a baseline night of uninterrupted sleep. On nights 3 and 4 subjects were asked to complete "intelligence" tests prior to sleep. One half of the subjects attempted to complete difficult versions of "i...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/8.3.244

    authors: Koulack D,Prevost F,De Koninck J

    更新日期:1985-01-01 00:00:00

  • Maxillomandibular Volume Influences the Relationship between Weight Loss and Improvement in Obstructive Sleep Apnea.

    abstract:STUDY OBJECTIVES:Obesity is the major risk factor for OSA; however, weight loss reduces OSA to a variable extent. We aimed to assess whether size of the maxillomandibular skeletal enclosure influences the relationship between weight loss and OSA reduction. METHODS:Obese males (≥ 30 kg/m2) with moderate-severe OSA (AHI...

    journal_title:Sleep

    pub_type: 临床试验,杂志文章

    doi:10.5665/sleep.5314

    authors: Sutherland K,Phillips CL,Yee BJ,Grunstein RR,Cistulli PA

    更新日期:2016-01-01 00:00:00

  • Subjective estimates of sleep differ from polysomnographic measurements in obstructive sleep apnea patients.

    abstract::It is well established that, as a group, insomnia patients overestimate sleep onset latency (SOL) and underestimate total sleep time (TST) when compared to objective polysomnographic (PSG) findings. Whether a similar phenomenon occurs with other sleep disorders is not fully established. We compared the PSG sleep of 84...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/18.8.646

    authors: McCall WV,Turpin E,Reboussin D,Edinger JD,Haponik EF

    更新日期:1995-10-01 00:00:00

  • Effects of sleep deprivation on performance: a meta-analysis.

    abstract::To quantitatively describe the effects of sleep loss, we used meta-analysis, a technique relatively new to the sleep research field, to mathematically summarize data from 19 original research studies. Results of our analysis of 143 study coefficients and a total sample size of 1.932 suggest that overall sleep deprivat...

    journal_title:Sleep

    pub_type: 杂志文章,meta分析

    doi:10.1093/sleep/19.4.318

    authors: Pilcher JJ,Huffcutt AI

    更新日期:1996-05-01 00:00:00

  • Therapeutic CPAP Level Predicts Upper Airway Collapsibility in Patients With Obstructive Sleep Apnea.

    abstract:Study Objectives:Upper airway collapsibility is a key determinant of obstructive sleep apnea (OSA) which can influence the efficacy of certain non-continuous positive airway pressure (CPAP) treatments for OSA. However, there is no simple way to measure this variable clinically. The present study aimed to develop a clin...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/zsx056

    authors: Landry SA,Joosten SA,Eckert DJ,Jordan AS,Sands SA,White DP,Malhotra A,Wellman A,Hamilton GS,Edwards BA

    更新日期:2017-06-01 00:00:00

  • The effect of sleep before or after learning on memory.

    abstract::Early studies in which it was found that learning followed by sleep was better remembered than learning followed by wakefulness were interpreted as giving support for the Interference Theory of Forgetting. More recent studies have shown better retention over the first half of the night's sleep (slow-wave sleep) than o...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/7.2.155

    authors: Grosvenor A,Lack LC

    更新日期:1984-01-01 00:00:00

  • MRI findings in narcolepsy.

    abstract::The neuropathology of narcolepsy is unknown. Recently, Plazzi et al. (1) reported magnetic resonance imaging (MRI) abnormalities in the pontine tegmentum of three patients with long-standing idiopathic narcolepsy. Considering the localization of the neuroradiological findings in the pontine reticular formation, where ...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/20.8.630

    authors: Bassetti C,Aldrich MS,Quint DJ

    更新日期:1997-08-01 00:00:00

  • Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies.

    abstract::Sleep-wake disturbances following traumatic brain injury (TBI) are increasingly recognized as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep-wake disturbances can persist for years, often impairing quality of life. Recently, there has been a nearly exponential increase in the...

    journal_title:Sleep

    pub_type: 杂志文章,评审

    doi:10.1093/sleep/zsx044

    authors: Sandsmark DK,Elliott JE,Lim MM

    更新日期:2017-05-01 00:00:00

  • Wake detection capacity of actigraphy during sleep.

    abstract:STUDY OBJECTIVES:To evaluate the ability of actigraphy compared to polysomnography (PSG) to detect wakefulness in subjects submitted to 3 sleep conditions with different amounts of wakefulness: a nocturnal sleep episode and 2 daytime recovery sleep episodes, one with placebo and one with caffeine. A second objective wa...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/30.10.1362

    authors: Paquet J,Kawinska A,Carrier J

    更新日期:2007-10-01 00:00:00

  • Effects of night work, sleep loss and time on task on simulated threat detection performance.

    abstract:STUDY OBJECTIVES:To investigate the effects of night work and sleep loss on a simulated luggage screening task (SLST) that mimicked the x-ray system used by airport luggage screeners. DESIGN:We developed more than 5,800 unique simulated x-ray images of luggage organized into 31 stimulus sets of 200 bags each. 25% of e...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:

    authors: Basner M,Rubinstein J,Fomberstein KM,Coble MC,Ecker A,Avinash D,Dinges DF

    更新日期:2008-09-01 00:00:00

  • Differences in insulin secretion and sensitivity in short-sleep insomnia.

    abstract:OBJECTIVE:Short-sleep insomnia is associated with increased risk of diabetes. The role of altered insulin secretion and action in this association is poorly understood. DESIGN:Observational study. SETTING:Academic clinical research center. PARTICIPANTS:Nondiabetic individuals with insomnia (mean [standard deviation]...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.5665/sleep.2734

    authors: Vasisht KP,Kessler LE,Booth JN 3rd,Imperial JG,Penev PD

    更新日期:2013-06-01 00:00:00

  • A workshop report on the causes and consequences of sleep health disparities.

    abstract::Sleep deficiencies, which include insufficient or long sleep duration, poor sleep quality, and irregular timing of sleep, are disproportionately distributed among populations that experience health disparities in the United States. Sleep deficiencies are associated with a wide range of suboptimal health outcomes, high...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/zsaa037

    authors: Jackson CL,Walker JR,Brown MK,Das R,Jones NL

    更新日期:2020-08-12 00:00:00

  • Local increase of sleep slow wave activity after three weeks of working memory training in children and adolescents.

    abstract:STUDY OBJECTIVES:Evidence is accumulating that electroencephalographic (EEG) sleep slow wave activity (SWA), the key characteristic of deep sleep, is regulated not only globally, but also locally. Several studies have shown local learning- and use-dependent changes in SWA. In vitro and in vivo animal experiments and st...

    journal_title:Sleep

    pub_type: 临床试验,杂志文章

    doi:10.5665/sleep.4580

    authors: Pugin F,Metz AJ,Wolf M,Achermann P,Jenni OG,Huber R

    更新日期:2015-04-01 00:00:00

  • Onset of Impaired Sleep and Cardiovascular Disease Risk Factors: A Longitudinal Study.

    abstract:STUDY OBJECTIVES:Impaired sleep has been linked to increased risk of cardiovascular disease (CVD), but the underlying mechanisms are still unsettled. We sought to determine how onset of impaired sleep affects the risk of established physiological CVD risk factors (i.e., hypertension, diabetes, and dyslipidemia). METHO...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.5665/sleep.6098

    authors: Clark AJ,Salo P,Lange T,Jennum P,Virtanen M,Pentti J,Kivimäki M,Rod NH,Vahtera J

    更新日期:2016-09-01 00:00:00

  • Prolonged assessment of sleep and daytime sleepiness in unrestrained Macaca mulatta.

    abstract:STUDY OBJECTIVE:To establish a method for the prolonged recording of electrophysiologic variables of sleep in freely moving nonhuman primates. To establish and validate means for scoring nocturnal sleep and quantifying daytime alertness in these subjects. DESIGN:Four animals (M. mulatta) were permanently instrumented ...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:

    authors: Daley JT,Turner RS,Freeman A,Bliwise DL,Rye DB

    更新日期:2006-02-01 00:00:00

  • An evidence-based recommendation for a new definition of respiratory-related leg movements.

    abstract:STUDY OBJECTIVES:Current sleep scoring rules exclude leg movements that occur near respiratory events from being scored as periodic leg movements during sleep (PLMS) but differ in whether they exclude leg movements occurring at the end (WASM/ IRLSSG) or during a respiratory event (AASM). The aim of the present study wa...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.5665/sleep.4418

    authors: Manconi M,Zavalko I,Fanfulla F,Winkelman JW,Fulda S

    更新日期:2015-02-01 00:00:00

  • Prolonged interval from body temperature nadir to sleep offset in patients with delayed sleep phase syndrome.

    abstract::In order to clarify the relationship between sleep-wake and core body temperature rhythms in the delayed sleep phase syndrome (DSPS), we conducted simultaneous monitoring of these rhythms in seven patients with DSPS and nine healthy control subjects for 6-10 days during their conventional sleep-wake schedules. The sle...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:

    authors: Ozaki S,Uchiyama M,Shirakawa S,Okawa M

    更新日期:1996-01-01 00:00:00

  • Short sleep duration in middle childhood: risk factors and consequences.

    abstract:STUDY OBJECTIVES:To measure sleep duration in 7-year-old children; identify the determinants of sleep duration; and assess the association between short sleep duration and obesity, cognitive functioning, and behaviour. DESIGN:Longitudinal study with disproportionate sampling of the participants. SETTING:Community. P...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/31.1.71

    authors: Nixon GM,Thompson JM,Han DY,Becroft DM,Clark PM,Robinson E,Waldie KE,Wild CJ,Black PN,Mitchell EA

    更新日期:2008-01-01 00:00:00

  • Parent-Reported Symptoms of Sleep-Disordered Breathing Are Associated With Increased Behavioral Problems at 2 Years of Age: The Canadian Healthy Infant Longitudinal Development Birth Cohort Study.

    abstract:Study Objectives:To examine the association between the age of onset and duration of parent-reported symptoms of sleep-disordered breathing (SDB) and behavioral problems at age 2. Methods:Parent-reported SDB symptoms were assessed quarterly between 3 months and 2 years among 583 Canadian Healthy Infant Longitudinal De...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/zsx177

    authors: Tamana SK,Smithson L,Lau A,Mariasine J,Young R,Chikuma J,Lefebvre DL,Subbarao P,Becker AB,Turvey SE,Sears MR,CHILD Study Investigators.,Pei J,Mandhane PJ

    更新日期:2018-01-01 00:00:00

  • Changes in Brain-Derived Neurotrophic Factor Expression Influence Sleep-Wake Activity and Homeostatic Regulation of Rapid Eye Movement Sleep.

    abstract:STUDY OBJECTIVES:Brain-derived neurotrophic factor (BDNF) expression and homeostatic regulation of rapid eye movement (REM) sleep are critical for neurogenesis and behavioral plasticity. Accumulating clinical and experimental evidence suggests that decreased BDNF expression is causally linked with the development of RE...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/zsx194

    authors: Garner JM,Chambers J,Barnes AK,Datta S

    更新日期:2018-02-01 00:00:00

  • Work-Family Conflict and Employee Sleep: Evidence from IT Workers in the Work, Family and Health Study.

    abstract:STUDY OBJECTIVES:Work-family conflict is a threat to healthy sleep behaviors among employees. This study aimed to examine how Work-to-Family Conflict (demands from work that interfere with one's family/personal life; WTFC) and Family-to-Work Conflict (demands from family/personal life that interfere with work; FTWC) ar...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.5665/sleep.6172

    authors: Buxton OM,Lee S,Beverly C,Berkman LF,Moen P,Kelly EL,Hammer LB,Almeida DM

    更新日期:2016-10-01 00:00:00

  • Actigraphy Measured Sleep Indices and Adiposity: The Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract:STUDY OBJECTIVES:To investigate the cross-sectional relationship between objectively measured sleep characteristics and multiple indices of adiposity in racially/ethnically diverse older adults within the MESA Sleep study (n = 2,146). METHODS:7-day actigraphy was used to assess sleep duration, sleep efficiency, and ni...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.5665/sleep.6096

    authors: Ogilvie RP,Redline S,Bertoni AG,Chen X,Ouyang P,Szklo M,Lutsey PL

    更新日期:2016-09-01 00:00:00

  • Work time control and sleep disturbances: prospective cohort study of Finnish public sector employees.

    abstract:OBJECTIVES:Employee control over work times has been associated with favorable psychosocial and health-related outcomes, but the evidence regarding sleep quality remains inconclusive. We examined cross-sectional and prospective associations between work time control and sleep disturbances in a large working population,...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.5665/sleep.3842

    authors: Salo P,Ala-Mursula L,Rod NH,Tucker P,Pentti J,Kivimäki M,Vahtera J

    更新日期:2014-07-01 00:00:00

  • Differential effect of intermittent hypoxia and sleep fragmentation on PD-1/PD-L1 upregulation.

    abstract::Immunosurveillance is compromised in patients with obstructive sleep apnea (OSA) as reflected by overexpression of the programmed death cell receptor and its ligand (PD-1/PD-L1) coinhibitory axis. However, the contributions of intermittent hypoxia (IH) and sleep fragmentation (SF) are unclear. We therefore evaluated t...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/zsz285

    authors: Cubillos-Zapata C,Almendros I,Díaz-García E,Toledano V,Casitas R,Galera R,López-Collazo E,Farre R,Gozal D,García-Rio F

    更新日期:2020-05-12 00:00:00

  • Baroreflex sensitivity during sleep in infants: impact of sleeping position and sleep state.

    abstract:STUDY OBJECTIVES:The prone sleeping position is a major risk for the sudden infant death syndrome (SIDS) and has been associated with lowered blood pressure and impaired blood pressure control. This study aimed to assess the effects of sleeping position, sleep state, and postnatal age on baroreflex control of heart rat...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.5665/SLEEP.1036

    authors: Yiallourou SR,Sands SA,Walker AM,Horne RS

    更新日期:2011-06-01 00:00:00

  • Life events in the year preceding the onset of narcolepsy.

    abstract::A multifactorial etiology for narcolepsy has been postulated, stressing the importance of environmental factors in the clinical onset of the condition. Our study evaluated the occurrence of stressful life events in the year preceding the onset of narcolepsy. Fifty narcoleptic and 50 control subjects completed a life e...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:10.1093/sleep/17.suppl_8.s50

    authors: Orellana C,Villemin E,Tafti M,Carlander B,Besset A,Billiard M

    更新日期:1994-12-01 00:00:00

  • Significance and treatment of nonapneic snoring.

    abstract::Snoring has been associated with an increased risk of vascular morbidity and mortality and with the complaint of excessive daytime sleepiness. Much of this risk may be attributable to concomitant sleep apnea or hypopnea. Recent work suggests that in certain individuals, snoring without apnea or hypopnea can lead to sl...

    journal_title:Sleep

    pub_type: 杂志文章

    doi:

    authors: Strollo PJ Jr,Sanders MH

    更新日期:1993-08-01 00:00:00