Genetic and environmental influences in sleep-disordered breathing in older male twins.


STUDY OBJECTIVES:To estimate the extent to which genetic factors contribute to the variation in several indices of sleep-disordered breathing in elderly male twins. DESIGN AND SETTING:A biometric genetic study based on data from unattended Edentrace recordings in a sample of elderly male twins. PARTICIPANTS:122 World War II male veteran twin pairs, including 68 monozygotic pairs aged 78.9 (+/- 2.7) years and 54 dizygotic pairs aged 78.4 (+/- 2.4) years. INTERVENTIONS:N/A. MEASUREMENTS AND RESULTS:The average (+/- SD) respiratory disturbance index for this sample was 17.2 +/- 14.5, the average (+/- SD) oxygen desaturation index was 18.8 +/- 16.4, and the average (+/- SD) minimum SaO2 level was 79.6 +/- 8.1%. Intraclass twin-pair correlations for log-transformed respiratory disturbance index were 0.59 in monozygotic pairs and 0.36 in dizygotic pairs. For oxygen desaturation index, intraclass correlations were 0.44 in monozygotic pairs and 0.24 in dizygotic pairs. For minimum SaO2, intraclass correlations were 0.38 and 0.11, respectively. Maximum likelihood estimates of heritability with associated 95% confidence intervals were 37% [22%, 52%] for respiratory disturbance index, 36% [19%, 53%] for oxygen desaturation index, and 10% [0%, 30%] for minimum SaO2. Adjustments of sleep-disordered breathing measures for age, body mass index, and waist and neck circumference had minimal effect on estimates of heritability. CONCLUSIONS:The present data indicate that sleep-disordered breathing, even in old age, is determined, in part, by genetic factors.






Carmelli D,Colrain IM,Swan GE,Bliwise DL




Has Abstract


2004-08-01 00:00:00














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    abstract:OBJECTIVES:To determine the incidence and remission rates of insomnia in older adults according to race and associated risk factors in a three-year longitudinal study. METHODS:2,971 men and women, aged 65 years and older, completed questionnaires administered by trained interviewers at baseline and three years later. ...


    pub_type: 杂志文章


    authors: Foley DJ,Monjan AA,Izmirlian G,Hays JC,Blazer DG

    更新日期:1999-05-01 00:00:00

  • Nasal CPAP in cardiac failure: case not proven.

    abstract::Cheyne-Stokes Respiration (CSR) has long been recognized to be associated with congestive cardiac failure. It is present in at least 45% of such patients with stable disease and is a predictor of future mortality. Nasal continuous positive airway pressure (CPAP) reduces the work of breathing in congestive cardiac fail...


    pub_type: 杂志文章,评审


    authors: Calverley PM

    更新日期:1996-12-01 00:00:00

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    authors: Grandner MA,Buxton OM,Jackson N,Sands-Lincoln M,Pandey A,Jean-Louis G

    更新日期:2013-05-01 00:00:00

  • Post-implant Care Pathway: lessons learned and recommendations after 5 years of clinical implementation of hypoglossal nerve stimulation.

    abstract::Hypoglossal nerve stimulation (HNS) therapy is now an established and widely-available OSA treatment alternative for CPAP-intolerant patients. Additionally, the HNS body of literature is robust with strong data on safety, efficacy, and durability - from the 5-year STAR Trial outcomes, to post-approval studies of indep...


    pub_type: 杂志文章


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    更新日期:2020-12-12 00:00:00

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    pub_type: 临床试验,杂志文章


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    更新日期:2016-01-01 00:00:00

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    更新日期:2013-11-01 00:00:00

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    authors: Bakker JP,O'Keeffe KM,Neill AM,Campbell AJ

    更新日期:2011-11-01 00:00:00

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    authors: Punjabi NM,Bandeen-Roche K,Young T

    更新日期:2003-09-01 00:00:00

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    更新日期:1995-11-01 00:00:00

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    authors: Sharafkhaneh A,Giray N,Richardson P,Young T,Hirshkowitz M

    更新日期:2005-11-01 00:00:00

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    pub_type: 杂志文章,meta分析


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    pub_type: 杂志文章


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    pub_type: 杂志文章,随机对照试验


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    更新日期:2019-05-01 00:00:00

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    pub_type: 杂志文章,随机对照试验


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    更新日期:2014-03-01 00:00:00