Abstract:
:The recently-discovered endogenous formation of amorphous magnesium-calcium phosphate nanoparticles (AMCPs) in human distal small intestine occurs in a complex environment, which is rich in biologically-relevant molecules and macromolecules that can shape the properties and the stability of these inorganic particles. In this work, we selected as case studies four diverse molecules, which have different properties and are representative of intestinal luminal components, namely butyric acid, lactose, gluten and peptidoglycan. We prepared AMCPs in the presence of these four additives and we investigated their effect on the features of the particles in terms of morphology, porosity, chemical nature and incorporation/adsorption. The combined use of electron microscopy, infrared spectroscopy and thermal analysis showed that while the morphology and microstructure of the particles do not depend on the type of additive present during the synthesis, AMCPs are able to incorporate a significant amount of peptidoglycan, similarly to the process in which they are involved in vivo.
journal_name
J Nanosci Nanotechnoljournal_title
Journal of nanoscience and nanotechnologyauthors
Gelli R,Salvestrini S,Ridi Fdoi
10.1166/jnn.2021.19049subject
Has Abstractpub_date
2021-05-01 00:00:00pages
2872-2878issue
5eissn
1533-4880issn
1533-4899journal_volume
21pub_type
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