Abstract:
:Evolved metabolic thriftiness in humans is a proposed contributor to the obesity epidemic. Insect models have been shown to evolve both 'metabolic thrift' in response to rearing on high-protein diets that promote leanness, and 'obesity resistance' when reared on fattening high-carbohydrate, low-protein foods. Despite the hypothesis that human obesity is caused by evolved metabolic thrift, genetic contributions to this physiological trait remain elusive. Here we conducted a pilot study to determine whether thrift and obesity resistance can arise under laboratory based 'quasi-natural selection' in the genetic model organism Drosophila melanogaster. We found that both these traits can evolve within 16 generations. Contrary to predictions from the 'thrifty genotype/phenotype' hypothesis, we found that when animals from a metabolic thrift inducing high-protein environment are mismatched to fattening high-carbohydrate foods, they did not become 'obese'. Rather, they accumulate less triglyceride than control animals, not more. We speculate that this may arise through as yet un-quantified parental effects - potentially epigenetic. This study establishes that D. melanogaster could be a useful model for elucidating the role of the trans- and inter-generational effects of diet on the genetics of metabolic traits in higher animals.
journal_name
Fly (Austin)journal_title
Flyauthors
J Gray L,B Sokolowski M,J Simpson Sdoi
10.1080/19336934.2021.1896960subject
Has Abstractpub_date
2021-12-01 00:00:00pages
47-59issue
1eissn
1933-6934issn
1933-6942journal_volume
15pub_type
杂志文章相关文献
文献大全abstract::Noroviruses interact with histo-blood group antigen (HBGA) receptors in a strain-specific manner probably detecting subtle structural differences in the carbohydrate receptors. The specific recognition of types A and B antigens by various norovirus strains is a typical example. The only difference between the types A ...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.3913
更新日期:2007-01-01 00:00:00
abstract::Displacement of [125I]reovirus from the surface of L cells by homologous and heterologous reovirus serotypes has indicated the presence of two different receptors. Corresponding experiments with Caco-2 cells and apical membrane vesicles suggest either two different receptors or different affinity of each reovirus sero...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.6621
更新日期:2008-07-01 00:00:00
abstract:PURPOSE:The repair of full-thickness defects of the eyelids poses a challenge, because the reconstruction of the tarsus-conjunctival layer often results in aesthetically and functionally unsatisfactory outcomes. The authors' aim was to create a new method to repair large tarsus-conjunctival losses and to examine the ou...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.6875
更新日期:2008-09-01 00:00:00
abstract::Cell signaling mediated by the Hedgehog (Hh) family of secreted proteins is essential for metazoan development and its malfunction causes congenital disorders and cancer. The seven-transmembrane protein Smoothened (Smo) transduces the Hh signal across the plasma membrane in both vertebrates and invertebrates but the u...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.4990
更新日期:2007-07-01 00:00:00
abstract::Cell signaling mediated by the Hedgehog (Hh) family of secreted proteins is essential for metazoan development and its malfunction causes congenital disorders and cancer. The seven-transmembrane protein Smoothened (Smo) transduces the Hh signal across the plasma membrane in both vertebrates and invertebrates but the u...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.4766
更新日期:2007-07-01 00:00:00
abstract::Cell signaling mediated by the Hedgehog (Hh) family of secreted proteins is essential for metazoan development and its malfunction causes congenital disorders and cancer. The seven-transmembrane protein Smoothened (Smo) transduces the Hh signal across the plasma membrane in both vertebrates and invertebrates but the u...
journal_title:Fly
pub_type: 杂志文章,评审
doi:10.4161/fly.3993
更新日期:2007-03-01 00:00:00
abstract::Cell signaling mediated by the Hedgehog (Hh) family of secreted proteins is essential for metazoan development and its malfunction causes congenital disorders and cancer. The seven-transmembrane protein Smoothened (Smo) transduces the Hh signal across the plasma membrane in both vertebrates and invertebrates but the u...
journal_title:Fly
pub_type: 杂志文章,评审
doi:10.4161/fly.5570
更新日期:2007-11-01 00:00:00
abstract::Breast conservation by wide local excision for early breast cancer is now considered safe and should be considered default therapy wherever possible. Unfortunately, this requires access to costly radiotherapy centers. Many women in the developing world or for that matter in wealthy countries with large land masses and...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.5247
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of bone marrow transplantation in children with Hunter syndrome. STUDY DESIGN:Eight boys received a bone marrow graft between the ages of 3 and 16 years from 1990 to 2000. In 6 cases, the donor was a sibling with identical HLA status, in 1 case an unrelated donor with HLA-compatible, a...
journal_title:Fly
pub_type: 杂志文章,评审
doi:10.4161/fly.3.1.7726
更新日期:2009-01-01 00:00:00
abstract::Nutrient removal in treatment wetlands declines during winter months due to temperature. A 3-mo (wintertime) mesocosm study was conducted to determine the effectiveness of alum in immobilizing P as well as other nutrients during this period of reduced treatment efficiency. Eighteen mesocosms, triplicate alum, and thre...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.7831
更新日期:2009-04-01 00:00:00
abstract::Nutrient removal in treatment wetlands declines during winter months due to temperature. A 3-mo (wintertime) mesocosm study was conducted to determine the effectiveness of alum in immobilizing P as well as other nutrients during this period of reduced treatment efficiency. Eighteen mesocosms, triplicate alum, and thre...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.8054
更新日期:2009-04-01 00:00:00
abstract:AIM:The aim was to obtain the information regarding the choice of antipsychotic drugs in the treatment of first episode schizophrenia. In particular, the factors influencing doctors' preferences and their opinion about several antipsychotics and the availability of these drugs were evaluated. METHODS:The anonymous que...
journal_title:Fly
pub_type: 杂志文章,评审
doi:10.4161/fly.8827
更新日期:2009-04-01 00:00:00
abstract::The phosphatidylinositol 3-kinase (PI3K) pathway controls the regulation of cell growth, proliferation, migration and apoptosis. In many tumors, the PI3K gene is mutated or overexpressed, and/or the PI3K pathway is hyperactive. PI3K is therefore a potential pharmacological target for the development of anti-tumor drug...
journal_title:Fly
pub_type: 杂志文章,评审
doi:10.4161/fly.3.1.7748
更新日期:2009-01-01 00:00:00
abstract::A central issue in genome-wide association (GWA) studies is assessing statistical significance while adjusting for multiple hypothesis testing. An equally important question is the statistical efficiency of the GWA design as compared to the traditional sequential approach in which genome-wide linkage analysis is follo...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.3.3.9138
更新日期:2009-07-01 00:00:00
abstract::The current study investigated the effects of cold pressor stress (CPS) on 2 working memory (WM) tasks differing in the demand they put on maintenance and executive processing. For this purpose 72 healthy young men were exposed either to a stress group or a nonstressful control group. Subsequently, WM performance on t...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.9978
更新日期:2009-10-01 00:00:00
abstract::Mammalian cells accumulate iron via the binding of transferrin to high affinity surface receptors, or through a transferrin-independent pathway which involves the uptake of iron-organic anion chelates by a membrane-based transport system. Previously we determined that the transferrin-independent transport system was p...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.10443
更新日期:2009-10-01 00:00:00
abstract::The obesity epidemic is in Germany as well as worldwide a major health problem which is associated with increased morbidity and mortality. Bariatric surgery is currently the most effective therapy for significant and sustained weight loss. The most common form of bariatric surgery worldwide is Roux-en-Y gastric bypass...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.4.1.10838
更新日期:2010-01-01 00:00:00
abstract::Proteasomes are large multisubunit complexes responsible for regulated protein degradation. Made of a core particle (20S) and regulatory caps (19S), proteasomal proteins are encoded by at least 33 genes, of which 12 have been shown to have testis-specific isoforms in Drosophila melanogaster. Pros28.1A (also known as P...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.4.1.11136
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To assess pragmatic challenges faced when implementing, delivering, and sustaining models of integrated mental health intervention in primary care settings. Thirty percent of primary care patients with chronic medical conditions and up to 80% of those with health complexity have mental health comorbidity, yet...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.4.3.12001
更新日期:2010-07-01 00:00:00
abstract:OBJECT:Stereotactic radiosurgery (SRS) is an important management option for patients with small- and medium-sized vestibular schwannomas. To assess the potential role of SRS in larger tumors, the authors reviewed their recent experience. METHODS:Between 1994 and 2008, 65 patients with vestibular schwannomas between 3...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.4.4.13148
更新日期:2010-10-01 00:00:00
abstract::Oleanolic acid (OA), a pentacyclic triterpenoid exhibits potent anti-tumor activity against many tumor cell lines. But the mechanisms through which OA inhibits osteosarcoma cells are not known. The mammalian target of rapamycin (mTOR) serves as a central regulator of cell growth, proliferation, survival, and metabolis...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.5.2.14396
更新日期:2011-04-01 00:00:00
abstract:AIM:To investigate associations between anxiety and measures of glycaemia in a White European and South Asian population attending community-based diabetes screening. METHODS:In total, 4688 White European and 1353 South Asian participants (aged 40-75 years) without a previous diagnosis of Type 2 diabetes underwent an ...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.5.4.16419
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:A lot of pathogens enter the body via the nasal route. The construction of non-toxic mutants of heat labile Escherichia coli enterotoxin (LT), which is a potent mucosal adjuvant, represents a major breakthrough for the development of mucosal vaccines. OBJECTIVE:This study was undertaken to critically evalua...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.5.4.17560
更新日期:2011-10-01 00:00:00
abstract::Lactobacillus sakei is a meat-borne lactic acid bacterium species exhibiting a wide genomic diversity. We have investigated the diversity of response to various oxidative compounds, between L. sakei strains, among a collection representing the genomic diversity. We observed various responses to the different compounds...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.18415
更新日期:2012-01-01 00:00:00
abstract::A method employing solid phase extraction followed by gas chromatography-mass spectrometry with negative chemical ionization has been developed for determination of ultratrace concentrations of perfluoroalkyl carboxylic acids in river water. The effects of the experimental parameters, such as the pH, additions of NaCl...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.18330
更新日期:2012-01-01 00:00:00
abstract:OBJECT:Liver cirrhosis was identified as an independent predictor of poor outcomes in patients suffering trauma and in those undergoing major surgeries. The aim of this study was to report the authors' experiences treating patients with cirrhosis who undergo brain surgeries. METHODS:Between 2004 and 2009, 121 consecut...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.19552
更新日期:2012-04-01 00:00:00
abstract::Methionine sulfoxide reductases A and B (MsrA and MsrB) have been known to be thioredoxin (Trx)-dependent enzymes that catalyze the reduction of methionine sulfoxide in a stereospecific manner. This work reports that glutaredoxin, another major thiol-disulfide oxidoreductase, can serve as a reductant for both MsrA and...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.19862
更新日期:2012-04-01 00:00:00
abstract::Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. In this review we summarize recent data elucidating the roles that the Wnt pathway play...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.20861
更新日期:2012-07-01 00:00:00
abstract::The absorption process in animals of TAK-491, designed as ester-based prodrug with medoxomil moiety, was evaluated. In the plasma of rats and dogs, TAK-536, the pharmacologically active metabolite, was present as the main component with hardly detectable concentrations of TAK-491 after oral administration of TAK-491. ...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.20999
更新日期:2012-07-01 00:00:00
abstract::Hering's law describes the equal and symmetrical rotation of the two eyes. It is possible to calibrate the binocular yoking of the two eyes in response to disparate size and/or motion of the two ocular images. It is unclear if the ratio of movements by the two eyes is modified by selective adaptation of each versional...
journal_title:Fly
pub_type: 杂志文章
doi:10.4161/fly.21161
更新日期:2012-10-01 00:00:00