Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.

abstract：:Metastasis formation is a multistep process that requires tumor cells to progress through many different stages. One of the first steps is a disturbance of the epithelial integrity through a decrease in intercellular homotypic adhesion. Proteolysis of the extracellular matrix, as well as increased locomotion, leads to...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： McKenzie JA,Batterham P

更新日期：1998-10-29 00:00:00

abstract：:A study was conducted to assess local fish consumption patterns and their relationship to concentrations of total polychlorinated biphenyls (PCBs) in the serum of Mohawk men residing near three hazardous waste sites. From 1992 to 1995, 139 men were interviewed and donated a 20-ml venous blood sample. The results indic...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Sykes B

更新日期：1999-01-29 00:00:00

abstract：:This multicenter, randomized, double-blind trial compared the efficacy and safety of ciprofloxacin (CIP; 500 mg twice daily for 10 days, placebo for 4 days) to those of clarithromycin (CLARI; 500 mg twice daily for 14 days) in 560 adults with clinically documented and radiologically confirmed acute sinusitis. Of 457 e...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Benfenati F,Onofri F,Giovedí S

更新日期：1999-02-28 00:00:00

abstract：:This multicenter, randomized, double-blind trial compared the efficacy and safety of ciprofloxacin (CIP; 500 mg twice daily for 10 days, placebo for 4 days) to those of clarithromycin (CLARI; 500 mg twice daily for 14 days) in 560 adults with clinically documented and radiologically confirmed acute sinusitis. Of 457 e...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Borst JG,Sakmann B

更新日期：1999-02-28 00:00:00

abstract：:This multicenter, randomized, double-blind trial compared the efficacy and safety of ciprofloxacin (CIP; 500 mg twice daily for 10 days, placebo for 4 days) to those of clarithromycin (CLARI; 500 mg twice daily for 14 days) in 560 adults with clinically documented and radiologically confirmed acute sinusitis. Of 457 e...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Cohen P

更新日期：1999-02-28 00:00:00

abstract：:This multicenter, randomized, double-blind trial compared the efficacy and safety of ciprofloxacin (CIP; 500 mg twice daily for 10 days, placebo for 4 days) to those of clarithromycin (CLARI; 500 mg twice daily for 14 days) in 560 adults with clinically documented and radiologically confirmed acute sinusitis. Of 457 e...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Butler PJ

更新日期：1999-03-29 00:00:00

abstract：:This multicenter, randomized, double-blind trial compared the efficacy and safety of ciprofloxacin (CIP; 500 mg twice daily for 10 days, placebo for 4 days) to those of clarithromycin (CLARI; 500 mg twice daily for 14 days) in 560 adults with clinically documented and radiologically confirmed acute sinusitis. Of 457 e...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Citovsky V

更新日期：1999-03-29 00:00:00

abstract：:We have investigated the impact of cellular environment on the neurite outgrowth promoting properties of the alternatively spliced fibronectin type-III region (fnA-D) of tenascin-C. FnA-D promoted neurite outgrowth in vitro when bound to the surface of BHK cells or cerebral cortical astrocytes, but the absolute increa...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Greenwood B

更新日期：1999-04-29 00:00:00

abstract：:Studies from animal models and in human volunteers have permitted to construct a provisional continuum of acceptable intakes of copper that would avoid copper deficiency and/or toxicity: acceptable intakes may vary between 10 and 50 mg/kg body weight. ...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Ekeberg O,Grillner S

更新日期：1999-05-29 00:00:00

abstract：:Tumors arising in the pancreatico-biliary system arise from the same embryological source and share several similar clinical features. For both sites, the mortality rate is high and early diagnosis is difficult. Despite these similarities, there are clear epidemiologic differences between cancers of the biliary tract ...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Reddy PH,Charles V,Williams M,Miller G,Whetsell WO Jr,Tagle DA

更新日期：1999-06-29 00:00:00

abstract：:Tumors arising in the pancreatico-biliary system arise from the same embryological source and share several similar clinical features. For both sites, the mortality rate is high and early diagnosis is difficult. Despite these similarities, there are clear epidemiologic differences between cancers of the biliary tract ...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Goedert M

更新日期：1999-06-29 00:00:00

abstract：:The complex process of lung formation is determined by the action of numerous genes that influence cell commitment, differentiation, and proliferation. This review summarizes current knowledge of various factors involved in lung morphogenesis correlating their temporal and spatial expression with their proposed functi...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Wagner AD,Koutstaal W,Schacter DL

更新日期：1999-07-29 00:00:00

abstract：:Stationary manometry is the gold standard for the evaluation of patients with suspected esophageal motility disorders. Comparison of videoesophagram in the evaluation of esophageal motility disorders with stationary motility has not been objectively studied. Two hundred two patients with foregut symptoms underwent sta...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Pelham HR

更新日期：1999-08-29 00:00:00

abstract：:In rats, rapid eye movement (REM) sleep can be elicited by microinjection of vasoactive intestinal polypeptide (VIP) into the oral pontine reticular nucleus (PnO). In the present study, we investigated whether this area could also be a REM-promoting target for a peptide closely related to VIP: the pituitary adenylyl c...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Ohsumi Y

更新日期：1999-09-29 00:00:00

abstract：BACKGROUND:The cytokine response to cardiopulmonary bypass (CPB) is complex and can be modified. Among several mediators, the anti-inflammatory interleukin-10 (IL-10, 'cytokine-secretion inhibitory factor') is particularly interesting because of its ability to counteract pro-inflammatory cytokines triggering endothelia...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Kandel ER,Pittenger C

更新日期：1999-12-29 00:00:00

abstract：:The molecular mechanisms underlying axonal pathfinding are not well understood. In a genetic screen for mutations affecting the projection of the larval optic nerve we isolated the abstrakt locus. abstrakt is required for pathfinding of the larval optic nerve, and it also affects development in both the adult visual s...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Stephan KE,Zilles K,Kötter R

更新日期：2000-01-29 00:00:00

abstract：:Werner's syndrome (WS) is a rare autosomal recessive human disorder and the patients exhibit many symptoms of accelerated ageing in their early adulthood. The gene (WRN) responsible for WS has been biochemically characterised as a 3'-5' helicase and is homologous to a number of RecQ superfamily of helicases. The yeast...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Camacho JP,Sharbel TF,Beukeboom LW

更新日期：2000-02-29 00:00:00

abstract：:Werner's syndrome (WS) is a rare autosomal recessive human disorder and the patients exhibit many symptoms of accelerated ageing in their early adulthood. The gene (WRN) responsible for WS has been biochemically characterised as a 3'-5' helicase and is homologous to a number of RecQ superfamily of helicases. The yeast...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Pelletier JD,Turcotte DL

更新日期：2000-02-29 00:00:00

abstract：PURPOSE:To evaluate the results of primary stenting in aortic occlusive disease. METHODS:Thirty patients underwent primary stenting of focal concentric (n = 2) and complex aortic stenoses (n = 19), and aortic or aorto-iliac occlusions (n = 9). Sixteen patients underwent endovascular outflow procedures, three of whom a...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： van Essen D,Dullforce P,Gray D

更新日期：2000-03-29 00:00:00

abstract：:High resolution structures of the active phosphorylated forms of two-component response regulators have recently been reported. The results provide a basis for understanding how metabolic energy is coupled to signal transduction in cellular regulatory networks. ...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Berry RM

更新日期：2000-04-29 00:00:00

abstract：:For didactic and documentation purposes the dermatoscopic ABCD rule and the dermatoscopic risk stratification have been proposed. The aim of this investigation was to compare the ability of the 2 methods to separate patients with cutaneous malignant melanoma from individuals with other pigmented skin lesions. Three de...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Hautefort I,Hinton JC

更新日期：2000-05-29 00:00:00

abstract：BACKGROUND:Few treatments are available for isolated pulmonary hypertension (PHT), which has a high morbidity and mortality. This trial was designed to assess the hemodynamic effects of bosentan, an endothelin receptor antagonist, in patients with PHT, in which local overproduction of endothelin-1 (ET-1) is thought to ...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Kenrick P

更新日期：2000-06-29 00:00:00

abstract：:One of the more unusual visual systems of the Actinopterygii is that of Pantodon buchholzi (Osteoglossomorpha: Osteoglossidae). Its adaptations associate neuroanatomy at different levels of the visual system with ecological and behavioural correlates and demonstrate that the visual system of this fish has adapted for ...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Webb JF,Smith WL

更新日期：2000-09-29 00:00:00

abstract：:One of the more unusual visual systems of the Actinopterygii is that of Pantodon buchholzi (Osteoglossomorpha: Osteoglossidae). Its adaptations associate neuroanatomy at different levels of the visual system with ecological and behavioural correlates and demonstrate that the visual system of this fish has adapted for ...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Saidel WM

更新日期：2000-09-29 00:00:00

abstract：:Previous studies have shown that expression of c-Jun protein, as well as the c-Jun amino-terminal kinase (JNK) group of mitogen-activated protein kinases, may play a critical role in the pathogenesis of glutamate neurotoxicity. In order to define the molecular cascade that leads to c-Jun activation following excitotox...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Reutter K,Boudriot F,Witt M

更新日期：2000-09-29 00:00:00

abstract：:Previous studies have shown that expression of c-Jun protein, as well as the c-Jun amino-terminal kinase (JNK) group of mitogen-activated protein kinases, may play a critical role in the pathogenesis of glutamate neurotoxicity. In order to define the molecular cascade that leads to c-Jun activation following excitotox...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Herring PJ

更新日期：2000-09-29 00:00:00

abstract：:Previous studies have shown that expression of c-Jun protein, as well as the c-Jun amino-terminal kinase (JNK) group of mitogen-activated protein kinases, may play a critical role in the pathogenesis of glutamate neurotoxicity. In order to define the molecular cascade that leads to c-Jun activation following excitotox...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： New JG,Kang PY

更新日期：2000-09-29 00:00:00

abstract：OBJECTIVE:To examine the effects of 17-wk physical exercise and enriched foods on cellular immune response (CIR) in frail elderly. METHODS:A total of 112 independently living, frail elderly men and women (mean age 79.2 +/- 5.9) received: twice weekly comprehensive, moderate intensity, progressive group exercise (group...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Godfray HC,Johnstone RA

更新日期：2000-11-29 00:00:00

abstract：OBJECTIVE:To examine the effects of 17-wk physical exercise and enriched foods on cellular immune response (CIR) in frail elderly. METHODS:A total of 112 independently living, frail elderly men and women (mean age 79.2 +/- 5.9) received: twice weekly comprehensive, moderate intensity, progressive group exercise (group...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Slatkin M

更新日期：2000-11-29 00:00:00

abstract：OBJECTIVE:To examine the effects of 17-wk physical exercise and enriched foods on cellular immune response (CIR) in frail elderly. METHODS:A total of 112 independently living, frail elderly men and women (mean age 79.2 +/- 5.9) received: twice weekly comprehensive, moderate intensity, progressive group exercise (group...

journal_title：Philosophical transactions of the Royal Society of London. Series B, Biological sciences

authors： Baroli I,Niyogi KK

更新日期：2000-10-29 00:00:00