Fabrication of substituted hydroxyapatite-starch-clay bio-composite coated titanium implant for new bone formation.

Abstract:

:The clay/polymeric matrices have much attention from researchers in bio-medical applications due to their numerous uses. This study introduces new orthopedic titanium (Ti) implant with increasing bio-activity by treating the surface of the Ti implant with bio-compatible composite coating. Wollastonite (WST) clay combined minerals (Mg2+and Gd3+) substituted hydroxyapatite (HAP)/Starch composite was prepared using in-situ co-precipitation method. It was successfully coated on the orthopedic grade Ti plate by the Electrophoretic Deposition (EPD) method. The functionality, phase, morphology, and bio-activity analysis of the composite were evaluated by FT-IR, XRD, HR-TEM, and SEM analysis, respectively. The mechanical property, i.e., Vickers microhardness value of the MHAP/Starch/WST composite coated Ti plate, showed 242 ± 1.92 Hv. The in-vitro MG-63 osteoblast cells viability, differentiation, and Ca mineralization of MHAP/Starch/WST composite suggests that this new implant will be used for bone regeneration application after careful evaluation of in-vivo and clinical studies.

journal_name

Carbohydr Polym

journal_title

Carbohydrate polymers

authors

Prabakaran S,Rajan M,Geng Z,Liu Y

doi

10.1016/j.carbpol.2021.118432

keywords:

["Bentonite clay (Pub Chem SID:24856869)","Calcium nitrate tetrahydrate (Pub Chem CID:16211656)","Clay-polymeric matrix","Diammonium hydrogen phosphate (Pub Chem CID:24540)","Electrophoretic deposition","Gadolinium nitrate hexahydrate (Pub Chem CID:209258)","Magnesium nitrate hexahydrate (Pub Chem SID:329752449)","Mineral substituted hydroxyapatite","Nitric acid (Pub chem CID: 944)","Potato starch (Pub Chem CID:24899595)","Sodium Sulfate (Pub Chem CID:24436)","Sodium bicarbonate (Pub Chem CID:516892)","Sulfuric acid (Pub Chem CID:1118)","Tissue engineering","Wollastonite"]

subject

Has Abstract

pub_date

2021-11-01 00:00:00

pages

118432

eissn

0144-8617

issn

1879-1344

pii

S0144-8617(21)00819-5

journal_volume

271

pub_type

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