A Chinese patient with the clinical features of Parkinson's disease contains a single copy of octarepeat deletion in PRNP case report.

abstract：:Human herpesvirus-6 (HHV-6) has been identified as the causal agent of exanthema subitum in early childhood (also called sixth disease or roseola), a mononucleosis-like disease in adults, and as an opportunistic pathogen in transplant recipients. In the latter setting, most infections are caused by reactivation of the...

journal_title：Prion

authors： Schutt CR,Bartz JC

更新日期：2008-04-01 00:00:00

abstract：:How autophagy, an evolutionarily conserved intracellular catabolic system for bulk degradation, selectively degrades protein aggregates is poorly understood. Here, we show that several maternally derived germ P granule components are selectively eliminated by autophagy in somatic cells during C. elegans embryogenesis....

journal_title：Prion

authors： Gazit E

更新日期：2007-01-01 00:00:00

abstract：:How autophagy, an evolutionarily conserved intracellular catabolic system for bulk degradation, selectively degrades protein aggregates is poorly understood. Here, we show that several maternally derived germ P granule components are selectively eliminated by autophagy in somatic cells during C. elegans embryogenesis....

journal_title：Prion

authors： Lefebvre-Roque M,Kremmer E,Gilch S,Zou WQ,Féraudet C,Gilles CM,Salès N,Grassi J,Gambetti P,Baron T,Schätzl H,Lasmézas CI

更新日期：2007-07-01 00:00:00

abstract：:How autophagy, an evolutionarily conserved intracellular catabolic system for bulk degradation, selectively degrades protein aggregates is poorly understood. Here, we show that several maternally derived germ P granule components are selectively eliminated by autophagy in somatic cells during C. elegans embryogenesis....

journal_title：Prion

authors： Pastor MT,Esteras-Chopo A,Serrano L

更新日期：2007-01-01 00:00:00

abstract：:We have previously shown that the first transcription start signal (TSS) of Zaire Ebola virus (ZEBOV) is involved in formation of an RNA secondary structure regulating VP30-dependent transcription activation. Interestingly, transcription of Marburg virus (MARV) minigenomes occurs independently of VP30. In this study, ...

journal_title：Prion

authors： Römer L,Scheibel T

更新日期：2008-10-01 00:00:00

abstract：:Monovalent antivenoms have a lower volume of specific antibodies that may reduce reactions but require accurate snake identification to be used. Polyvalent antivenoms are larger volume and may have a higher reaction rate. However, they avoid the problem of snake identification and may be more cost-effective to manufac...

journal_title：Prion

authors： Kobayashi A,Hizume M,Teruya K,Mohri S,Kitamoto T

更新日期：2009-01-01 00:00:00

abstract：:Histopathologic features were studied in postmortem examination of two men with adrenomyeloneuropathy, and biochemical studies were performed on one of these individuals. The histopathologic picture of one case included dying-back features in the nervous system and lamellar cytoplasmic inclusions in the brain, adrenal...

journal_title：Prion

authors： Rincon-Limas DE,Casas-Tinto S,Fernandez-Funez P

更新日期：2010-01-01 00:00:00

abstract：:Research to date in young children and adults shows a strong, inverse relationship between sleep duration and risk for overweight and obesity. Fewer studies examining this relationship have been conducted in adolescents. The purpose of the article is to describe the relationship between sleep and weight in a populatio...

journal_title：Prion

authors： Gough KC,Maddison BC

更新日期：2010-10-01 00:00:00

abstract：:Research to date in young children and adults shows a strong, inverse relationship between sleep duration and risk for overweight and obesity. Fewer studies examining this relationship have been conducted in adolescents. The purpose of the article is to describe the relationship between sleep and weight in a populatio...

journal_title：Prion

authors： Telling GC

更新日期：2010-10-01 00:00:00

abstract：:Research to date in young children and adults shows a strong, inverse relationship between sleep duration and risk for overweight and obesity. Fewer studies examining this relationship have been conducted in adolescents. The purpose of the article is to describe the relationship between sleep and weight in a populatio...

journal_title：Prion

authors： Gunapala KM,Chang D,Hsu CT,Manaye K,Drenan RM,Switzer RC,Steele AD

更新日期：2010-10-01 00:00:00

abstract：:The in vivo wavelength dependence of hematoporphyrin derivative (HpD) photodynamic treatment (PDT) has been studied. Ears of 136 rats were treated at six red and four blue-green laser wavelengths (615-635, 488-514.5 nm). Hematoporphyrin derivative was administered intraperitoneally (15 mg/kg) and 24 h later both ears ...

journal_title：Prion

authors： Kang SG,Roh YM,Lau A,Westaway D,McKenzie D,Aiken J,Kim YS,Yoo HS

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Angiogenesis is an indispensable process during tumor development. The currently accepted standard method for quantifying tumor angiogenesis is to assess microvessel density (MVD) based on CD105 staining, which is an independent prognostic factor for survival in patients with most solid tumor types. The goal of...

journal_title：Prion

authors： Miranda A,Pericuesta E,Ramírez MÁ,Gutiérrez-Adán A

更新日期：2011-07-01 00:00:00

abstract：:Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of t...

journal_title：Prion

authors： Reidy M,Masison DC

更新日期：2011-10-01 00:00:00

abstract：:Although the NINCDS-ADRDA Work Group has recently developed uniform clinical criteria for the diagnosis of Alzheimer's disease (AD), inter-rater reliability studies of these criteria are few. We report a study in which 2 neurologists and 2 psychiatrists independently reviewed clinical data abstracted from the records ...

journal_title：Prion

authors： Hines JK,Higurashi T,Srinivasan M,Craig EA

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND/AIM:X-linked adrenal hypoplasia congenita (AHC) is a rare disorder characterized by primary adrenal insufficiency and hypogonadic hypogonadism. It is caused by deletions or point mutations of the NR0B1 gene, on Xp21. AHC can be associated with glycerol kinase deficiency, Duchenne muscular dystrophy and menta...

journal_title：Prion

authors： Daus ML,Beekes M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND/AIM:X-linked adrenal hypoplasia congenita (AHC) is a rare disorder characterized by primary adrenal insufficiency and hypogonadic hypogonadism. It is caused by deletions or point mutations of the NR0B1 gene, on Xp21. AHC can be associated with glycerol kinase deficiency, Duchenne muscular dystrophy and menta...

journal_title：Prion

authors： Abdallah A,Wang P,Richt JA,Sreevatsan S

更新日期：2012-01-01 00:00:00

abstract：:Series (Fowler) dead space (VD) and slope of the alveolar plateau of two inert gases (He and SF6) with similar blood-gas partition coefficients (approximately 0.01) but different diffusivities were analyzed in 10 anesthetized paralyzed mechanically ventilated dogs (mean body wt 20 kg). Single-breath constant-flow expi...

journal_title：Prion

authors： Masliah E,Rockenstein E,Inglis C,Adame A,Bett C,Lucero M,Sigurdson CJ

更新日期：2012-04-01 00:00:00

abstract：:Alar base retraction is a common yet difficult problem faced by the rhinoplasty surgeon. It may be caused by weakened, overresected lateral crura, vestibular lining deficiencies, or congenital alar malpositioning. Methods of correction include soft tissue manipulation, auricular composite grafting, and cartilage graft...

journal_title：Prion

authors： Maddison BC,Owen JP,Taema MM,Shaw G,Gough KC

更新日期：2012-07-01 00:00:00

abstract：:Alar base retraction is a common yet difficult problem faced by the rhinoplasty surgeon. It may be caused by weakened, overresected lateral crura, vestibular lining deficiencies, or congenital alar malpositioning. Methods of correction include soft tissue manipulation, auricular composite grafting, and cartilage graft...

journal_title：Prion

authors： Herva ME,Weissman C

更新日期：2012-09-01 00:00:00

abstract：:Patients with pancreatic cancer frequently suffer from both biliary and duodenal obstruction. For such patients, both biliary and duodenal self-expandable metal stent placement is necessary to palliate their symptoms, but it was difficult to cross two metal stents. Recently, endoscopic ultrasonography-guided choledoch...

journal_title：Prion

authors： Moda F,Vimercati C,Campagnani I,Ruggerone M,Giaccone G,Morbin M,Zentilin L,Giacca M,Zucca I,Legname G,Tagliavini F

更新日期：2012-09-01 00:00:00

abstract：:A receptor model analysis has been applied to ambient PM(2.5) measurements taken at Santiago, Chile (33.5°S, 70.7°W) in 2004 (117 samples) and in 1999 (95 samples) on a receptor site on the eastern side of the city. For both campaigns, six sources have been identified at Santiago and their contributions in 1999/2004 a...

journal_title：Prion

authors： Zhang J,Dong XP

更新日期：2012-09-01 00:00:00

abstract：:A simple technique is described for lightening overly dark radiographs in the interest of enhancing them for display or for making photographic slides or prints. The object of the technique is to remove the emulsion from one side of the radiograph. ...

journal_title：Prion

authors： Nussbaum JM,Seward ME,Bloom GS

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To investigate the hemostatic capability of mono- and bipolar transurethral resection of the prostate by comparing the perioperative blood loss with the coagulation depth achieved with mono- and bipolar transurethral resection of the prostate. METHODS:A total of 136 patients with lower urinary tract symptoms...

journal_title：Prion

authors： Um JW,Strittmatter SM

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To investigate the hemostatic capability of mono- and bipolar transurethral resection of the prostate by comparing the perioperative blood loss with the coagulation depth achieved with mono- and bipolar transurethral resection of the prostate. METHODS:A total of 136 patients with lower urinary tract symptoms...

journal_title：Prion

authors： Sang JC,Lee CY,Luh FY,Huang YW,Chiang YW,Chen RP

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Intracerebral haemorrhage (ICH) remains the most devastating yet unpredictable complication of intravenous thrombolysis for acute ischaemic stroke. We performed a systematic review and meta-analysis, to assess whether the presence of cerebral microbleeds (CMBs) on prethrombolysis MRI scans is associated with...

journal_title：Prion

authors： Jang B,Ishigami A,Maruyama N,Carp RI,Kim YS,Choi EK

更新日期：2013-01-01 00:00:00

abstract：:In this study operative blood loss was measured in 177 transurethral prostatectomies performed over a six-year period in one hospital by the author. A comparison was made relative to type of anaesthesia used i.e. general inhalation versus spinal anaesthesia. The two groups were similar in age and physical condition. T...

journal_title：Prion

authors： Passet B,Halliez S,Béringue V,Laude H,Vilotte JL

更新日期：2013-03-01 00:00:00

abstract：:Ligands for ErbB1-4 receptor tyrosine kinases, such as epidermal growth factor (EGF) and neuregulins, regulate brain development and function. Thus, abnormalities in their signaling are implicated in the etiology or pathology of schizophrenia and Parkinson's disease. Among the ErbB receptors, ErbB1, and ErbB4 are expr...

journal_title：Prion

authors： Schmidt C,Artjomova S,Hoeschel M,Zerr I

更新日期：2013-05-01 00:00:00

abstract：:Health care at population level is a complex problem. Having this in mind, the purpose of this paper is to focus on the goods that are ethically relevant in the process of caring for health at this level. We briefly analyze some of the Chilean health statistics that, although they show important improvements along the...

journal_title：Prion

authors： Elmallah MI,Borgmeyer U,Betzel C,Redecke L

更新日期：2013-09-01 00:00:00

abstract：:Of the approximately 795,000 strokes in the United States annually, 87% are ischemic and result in significant morbidity and mortality. Improvements in acute ischemic stroke (AIS) outcomes have been achieved with intravenous thrombolytics (IVT) and intra-arterial thrombolytics vs supportive medical therapy. Given its ...

journal_title：Prion

authors： Kabir ME,Safar JG

更新日期：2014-01-01 00:00:00

abstract：:Prions are a novel form of infectivity based on the misfolding of a self-protein (PrP(C)) into a pathological, infectious isomer (PrP(Sc)). The current uncontrolled spread of chronic wasting disease in cervids, coupled with the demonstrated zoonotic nature of select livestock prion diseases, highlights the urgent need...

journal_title：Prion

authors： Taschuk R,Marciniuk K,Määttänen P,Madampage C,Hedlin P,Potter A,Lee J,Cashman NR,Griebel PJ,Napper S

更新日期：2014-01-01 00:00:00