Sestrin2 in hypoxia and hypoxia-related diseases.

abstract：:Antioxidant enzymes function to eliminate reactive oxygen species (ROS) produced as a consequence of normal metabolic functions as well as environmental stress. In these studies, the responses of catalase (Cat), superoxide dismutase (Sod) and glutathione S-transferase (Gst), as well as D-ribulose-1,5-bisphosphate carb...

journal_title：Redox report : communications in free radical research

authors： Ruzsa SM,Mylona P,Scandalios JG

更新日期：1999-01-01 00:00:00

abstract：:The effects of reactive nitrogen species on glutathione homeostasis in human endothelial ECV 304 cells challenged by 3-morpholinosydnonimine-N-ethylcarbamide (SIN-1) on RAW 264.7 activated macrophages using a co-culture model were investigated. SIN-1 or macrophages activated by lipopolysaccharide plus interferon-gamma...

journal_title：Redox report : communications in free radical research

authors： Rimbach G,Virgili F,Park YC,Packer L

更新日期：1999-01-01 00:00:00

abstract：:NAD(P)H:quinone oxidoreductase 1 (NQO1), a redox-regulated flavoenzyme, plays a central role in monitoring cellular redox state. NQO1 acts to protect against oxidative stress induced by a variety of metabolic situations, including metabolism of quinones and other xenobiotics, by: (i) functioning as a two electron dono...

journal_title：Redox report : communications in free radical research

authors： Raina AK,Templeton DJ,Deak JC,Perry G,Smith MA

更新日期：1999-01-01 00:00:00

abstract：:Full blood counts, ESR, CRP, haematinics and markers for oxidative stress were measured for 33 patients diagnosed with chronic fatigue syndrome (CFS) and 27 age and sex matched controls. All participants also completed symptom questionnaires. CFS patients had increases in malondialdehyde (P <0.006), methaemoglobin (P ...

journal_title：Redox report : communications in free radical research

authors： Richards RS,Roberts TK,McGregor NR,Dunstan RH,Butt HL

更新日期：2000-01-01 00:00:00

abstract：:Plant-derived isoflavones are currently receiving much attention because of their phyto-estrogenic and antioxidant activities. In this study, we describe novel photoprotective effects of one isoflavone derivative from red clover (NV07), following its application topically in Skh:HR-1 hairless mice. We found that in mi...

journal_title：Redox report : communications in free radical research

authors： Widyarini S,Spinks N,Reeve VE

更新日期：2000-01-01 00:00:00

abstract：:Myeloperoxidase is very susceptible to reducing radicals because the reduction potential of the ferric/ferrous redox couple is much higher compared with other peroxidases. Semiquinone radicals are known to reduce heme proteins. Therefore, the kinetics and spectra of the reactions of p-hydroquinone, 2,3-dimethylhydroqu...

journal_title：Redox report : communications in free radical research

authors： Burner U,Krapfenbauer G,Furtmüller PG,Regelsberger G,Obinger C

更新日期：2000-01-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae has been extensively utilised to address the mechanisms underlying the oxidative stress response. The antioxidant defences can be induced either by respiratory growth or in the presence of pro-oxidants. The cell response involves the transcriptional control of genes by protein regula...

journal_title：Redox report : communications in free radical research

authors： Moradas-Ferreira P,Costa V

更新日期：2000-01-01 00:00:00

abstract：:We present an up-to-date insight into the function of NADPH oxidase in human neutrophils, the signalling pathways involved in activation of this enzyme and the process of association of its components with the cytoskeleton. We also discuss the functional implications of morphological studies revealing localization of ...

journal_title：Redox report : communications in free radical research

authors： Kobayashi T,Tsunawaki S,Seguchi H

更新日期：2001-01-01 00:00:00

abstract：:The antioxidant activity of capsaicin (CAP) was measured in the oxidation of methyl linoleate (ML) in homogeneous solution, of ML micelles in aqueous dispersions and also of soybean phosphatidylcholine liposomal membrane, and was compared to that of alpha-tocopherol (alpha-TOH) which is one of the most important antio...

journal_title：Redox report : communications in free radical research

authors： Okada Y,Okajima H

更新日期：2001-01-01 00:00:00

abstract：:Reactive oxygen species and lipid peroxidation play a role in the pathogenesis induced by the non-steroidal anti-inflammatory drug indomethacin. Melatonin (MLT) protection against indomethacin-induced oxidative tissue injury was investigated in gastric mucosa and testis of rats. MLT was administered intragastrically (...

journal_title：Redox report : communications in free radical research

authors： Othman AI,El-Missiry MA,Amer MA

更新日期：2001-01-01 00:00:00

abstract：:The plasma protein haptoglobin and the endocytic hemoglobin receptor HbSR/CD163 are key molecules in the process of removing hemoglobin released from ruptured erythrocytes. Hemoglobin in plasma is instantly bound with high affinity to haptoglobin--an interaction leading to the recognition of the complex by HbSR/CD163 ...

journal_title：Redox report : communications in free radical research

authors： Madsen M,Graversen JH,Moestrup SK

更新日期：2001-01-01 00:00:00

abstract：:We have shown that 1,2-diacylglycerol hydroperoxides activate protein kinase C (PKC) as efficiently as does phorbol ester [Takekoshi S, Kambayashi Y, Nagata H, Takagi T, Yamamoto Y, Watanabe K. Activation of protein kinase C by oxidized diacylglycerol. Biochem Biophys Res Commun 1995; 217: 654-660]. 1,2-Diacylglycerol...

journal_title：Redox report : communications in free radical research

authors： Kambayashi Y,Takekoshi S,Watanabe K,Yamamoto Y

更新日期：2002-01-01 00:00:00

abstract：:The detailed chemistry of nitric oxide (*NO) and regulation of this potent signal molecule through interactions with cellular components are complex and not clearly understood. In the vasculature, *NO plays a crucial role in vessel dilation by activating soluble guanylyl cyclase (sGC) in vascular smooth muscle cells (...

journal_title：Redox report : communications in free radical research

authors： Andriambeloson E,Witting PK

更新日期：2002-01-01 00:00:00

abstract：:It is thought that disulfide bonds in secreted proteins are inert because of the oxidizing nature of the extracellular milieu. We have suggested that this is not necessarily the case and that certain secreted proteins contain one or more disulfide bonds that can be cleaved and that this cleavage is central to the prot...

journal_title：Redox report : communications in free radical research

authors： Hogg PJ

更新日期：2002-01-01 00:00:00

abstract：:Elevated extracellular glutamate levels can increase malondialdehyde production in the brains of anesthetized rats. Thus, we investigated whether ionotropic glutamate receptors are involved in glutamate-induced malondialdehyde production. A microdialysis probe was implanted in the brain cortex of anesthetized rats. Th...

journal_title：Redox report : communications in free radical research

authors： Yang CS,Tsai PJ,Chen WY,Kuo JS

更新日期：2003-01-01 00:00:00

abstract：:Oxidative stress induced by hyperglycemia possibly causes the dysfunction of pancreatic beta-cells and various forms of tissue damage in patients with diabetes mellitus. Astaxanthin, a carotenoid of marine microalgae, is reported as a strong anti-oxidant inhibiting lipid peroxidation and scavenging reactive oxygen spe...

journal_title：Redox report : communications in free radical research

authors： Uchiyama K,Naito Y,Hasegawa G,Nakamura N,Takahashi J,Yoshikawa T

更新日期：2002-01-01 00:00:00

abstract：:The kinetics of DNA and protein damage in two lines of cultured cells exposed to radiation-generated hydroxyl free radicals were measured. The results show that DNA damage is a relatively late event, preceded by the formation of protein hydroperoxides which may play a role in the degradation of the DNA. ...

journal_title：Redox report : communications in free radical research

authors： Du J,Gebicki JM

更新日期：2002-01-01 00:00:00

abstract：:This study was designed to evaluate the effect of high concentrations of melatonin on the peroxidation of human low density lipoproteins (LDLs) initiated by O(2)(*-) and ethanol-derived peroxyl radicals (RO(2)(*)) from water gamma radiolysis in the presence of ethanol. LDL (3 g/l; total LDL concentration) was oxidized...

journal_title：Redox report : communications in free radical research

authors： Bonnefont-Rousselot D,Guilloz V,Lepage S,Bizard C,Duriez P,Lesieur D,Delattre J,Jore D,Gardès-Albert M

更新日期：2003-01-01 00:00:00

abstract：:This paper describes the discovery of a novel free radical scavenger, 3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone, 1), as a potent antioxidant agent against lipid peroxidation. The structure-activity relationship of edaravone indicated that lipophilic substituents were essential to show its lipid peroxidation-inhib...

journal_title：Redox report : communications in free radical research

authors： Watanabe K,Morinaka Y,Iseki K,Watanabe T,Yuki S,Nishi H

更新日期：2003-01-01 00:00:00

abstract：:Enhanced oxidative stress is implicated in the pathogenesis of Parkinson's disease. The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) induces the production of reactive oxygen species (ROS), leading to neuronal cell death. On the other hand, apomorphine, a dopamine D1/D2 receptor agonist and known as a poten...

journal_title：Redox report : communications in free radical research

authors： Hara H,Ohta M,Ohta K,Kuno S,Adachi T

更新日期：2003-01-01 00:00:00

abstract：:Heterozygous thalassemia and sickle cell disease produce mild hematological symptoms but provide protection against malaria mortality and severe malaria symptoms. Two explanations for resistance are considered in the literature - impaired growth of the parasite or enhanced removal by the host immune cells. A critical ...

journal_title：Redox report : communications in free radical research

authors： Akide-Ndunge OB,Ayi K,Arese P

更新日期：2003-01-01 00:00:00

abstract：:Peptide methionine sulfoxide reductases are important enzymes in the defense against cellular oxidative stress as they reduce methionine sulfoxide, the product of methionine oxidation by physiologically relevant reactive oxygen species. Two distinct enzyme classes, MSRA and MSRB, have evolved for selectively reducing ...

journal_title：Redox report : communications in free radical research

authors： Hansel A,Jung S,Hoshi T,Heinemann SH

更新日期：2003-01-01 00:00:00

abstract：:Four analogues of Ebselen were synthesized and their glutathione peroxidase activity and antioxidant property evaluated and compared to Ebselen. Among the studied compounds, only diselenide [3] exhibited both glutathione peroxidase activity and radical-scavenging capability. Compounds [3] and [4] showed a strong inhib...

journal_title：Redox report : communications in free radical research

authors： Mouithys-Mickalad Mareque A,Faez JM,Chistiaens L,Kohnen S,Deby C,Hoebeke M,Lamy M,Deby-Dupont G

更新日期：2004-01-01 00:00:00

abstract：:There is evidence that omega-3 (omega3) fatty acids derived from fish and fish oils reduce the risk of cardiovascular disease via mechanisms underlying atherosclerosis, thrombosis and inflammation. Despite these benefits, there has been concern that these fatty acids may increase lipid peroxidation. However, the in vi...

journal_title：Redox report : communications in free radical research

authors： Mori TA

更新日期：2004-01-01 00:00:00

abstract：:Rapid perfusion of oxygen in infants at birth may increase oxidative stress which has been incriminated in serious diseases including neonatal respiratory distress syndrome, chronic lung disease, and retinopathy of prematurity. Elucidating the antioxidant defense systems of neonates in clinical practice is important. ...

journal_title：Redox report : communications in free radical research

authors： Sato S,Tsukahara H,Ohshima Y,Ohta N,Uchiyama M,Sekine K,Uetake T,Mayumi M

更新日期：2004-01-01 00:00:00

abstract：:Trans-plasma membrane electron transport (tPMET) in mammalian cells has been demonstrated using artificial cell-impermeable dyes, but the extent to which reduction of these dyes involves distinct pathways remains unclear. Here we compare the properties of three commonly used dyes, WST-1, FeCN and DCIP. The presence of...

journal_title：Redox report : communications in free radical research

authors： Tan AS,Berridge MV

更新日期：2004-01-01 00:00:00

abstract：:The objectives were to determine the effects of alacepril, an angiotensin-converting enzyme inhibitor, on the expression of adhesion molecules and monocyte adherence to endothelial cells induced by 7-ketocholesterol (7-KC) and tumor necrosis factor (TNF)-alpha. We used human aortic endothelial cells (HAECs) and U937 m...

journal_title：Redox report : communications in free radical research

authors： Shimozawa M,Naito Y,Manabe H,Uchiyama K,Katada K,Kuroda M,Nakabe N,Yoshida N,Yoshikawa T

更新日期：2004-01-01 00:00:00

abstract：:Many biological properties have been attributed to ruthenium complexes including anti-tumor activity and the attenuation of reperfusion damage and infarct size. In this work, we characterize the antioxidant activity of trans-[RuCl2(nic)4] where nic is 3-pyridinecarboxylic acid and trans-[RuCl2(i-nic)4] where i-nic is ...

journal_title：Redox report : communications in free radical research

authors： Paula MM,Pich CT,Petronilho F,Drei LB,Rudnicki M,de Oliveira MR,Moreira JC,Henriques JA,Franco CV,Dal Pizzol F

更新日期：2005-01-01 00:00:00

abstract：:The production of ROS is an inevitable consequence of metabolism. However, high levels of ROS within a cell can be lethal and so the cell has a number of defences against oxidative cell stress. Occasionally the cell's antioxidant mechanisms fail and oxidative stress occurs. High levels of ROS within a cell have a numb...

journal_title：Redox report : communications in free radical research

authors： England K,Cotter TG

更新日期：2005-01-01 00:00:00

abstract：:Farnesol is an isoprenoid found in essential oils of ambrette seeds, citronella and in various aromatic plants. Exposure to cadmium from various sources affects the renal system adversely and Cd is an established genotoxic agent. In the present study, we evaluated the antigenotoxic and antioxidant efficacy of farnesol...

journal_title：Redox report : communications in free radical research

authors： Jahangir T,Khan TH,Prasad L,Sultana S

更新日期：2005-01-01 00:00:00