Abstract:
:The Covid-19 disease has recently become one of the biggest challenges globally, and there is still no specific medication. Findings showed the immune system in severe Covid-19 patients loses regulatory control of pro-inflammatory cytokines, especially IL-6 production, called the "Cytokine storm" process. This process can cause injury to vital organs, including lungs, kidneys, liver, and ultimately death if not inhibited. While many treatments have been proposed to reduce cytokine storm, but the safety and effectiveness of each of them are still in doubt. Mesenchymal stem cells (MSCs) are multipotent cells with self-renewal potential capable of suppressing overactive immune responses and leading to tissue restoration and repair. These immuno-modulatory properties of MSCs and their derivatives (like exosomes) can improve the condition of Covid-19 patients with serious infectious symptoms caused by adaptive immune system dysfunction. Many clinical trials have been conducted in this field using various MSCs around the world. Some of these have been published and summarized in the present article, while many have not yet been completed. Based on these available data, MSCs can reduce inflammatory cytokines, increase oxygen saturation, regenerate lung tissue and improve clinical symptoms in Covid-19 patients. The review article aims to collect available clinical data in more detail and investigate the role of MSCs in reducing cytokine storms as well as improving clinical parameters of Covid-19 patients for use in future clinical studies.
journal_name
Regen Therjournal_title
Regenerative therapyauthors
Kaffash Farkhad N,Reihani H,Sedaghat A,Moghadam AA,Moghadam AB,Tavakol-Afshari Jdoi
10.1016/j.reth.2021.05.007keywords:
["Covid-19","Cytokine storm","Immune response","Mesenchymal stem cells"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
152-160issn
2352-3204pii
S2352-3204(21)00045-6journal_volume
18pub_type
杂志文章,评审abstract:Background:The present study focused on burning as one of the main causes of mortality with detrimental economic and social effects in the world. The purpose of this study was to investigate the impact of collagen-chitosan gel extracted from Scomberomorus guttatus and shrim...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2021.03.001
更新日期:2021-03-18 00:00:00
abstract:Introduction:Intraportal islet transplantation is a promising therapeutic approach for patients with type 1 diabetes mellitus (T1DM). However, despite being minimally invasive, the method has some limitations, such as short-term graft loss, portal venous thrombosis, and difficulty in collecting adequate amounts of isle...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2020.12.005
更新日期:2021-01-13 00:00:00
abstract::Osteonecrosis of the femoral head (ONFH) is a progressive disease with a complex etiology and unclear pathogenesis, resulting in severe hip pain and dysfunction mainly observed in young patients. Although total hip arthroplasty (THA) is the most effective treatment for patients with ONFH in the terminal stage, the res...
journal_title:Regenerative therapy
pub_type: 杂志文章,评审
doi:10.1016/j.reth.2020.11.003
更新日期:2020-11-28 00:00:00
abstract:Introduction:Responses of oral-microflora-exposed dental pulp to a triple antibiotic paste (TAP), a mixture of ciprofloxacin, metronidazole, and minocycline in ointment with macrogol and propylene glycol, remain to be fully clarified at the cellular level. This study aimed to elucidate responses of oral-microflora-expo...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2020.10.001
更新日期:2020-10-29 00:00:00
abstract::Wound healing requires well-coordinated events including hemostasis, inflammation, proliferation, and remodeling. Delays in any of these stages leads to chronic wounds, infections, and hypertrophic scarring. Burn wounds are particularly problematic, and may require intervention to ensure timely progression to reduce m...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2020.07.004
更新日期:2020-08-06 00:00:00
abstract:Introduction:Neural crest (NC)-like stem/progenitor cells provide an attractive cell source for regenerative medicine because of their multipotent property and ease of isolation from adult tissue. Although human umbilical cord blood (HUCB) is known to be a rich source of stem cells, the presence of the NC-like stem/pro...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2020.06.001
更新日期:2020-07-18 00:00:00
abstract:Introduction:The objective of this study is to evaluate the effect of basic fibroblast growth factor (bFGF) on the proliferation and secretion activity of feline adipose-derived mesenchymal stem cells (MSC). Methods:Feline MSC isolated from the subcutaneous adipose tissue of cats were cultured with or without bFGF. R...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2020.03.013
更新日期:2020-05-26 00:00:00
abstract::Because of the growing demand for human cell spheroids as functional cellular components for both drug development and regenerative therapy, the technology to non-invasively evaluate their quality has emerged. Image-based morphology analysis of spheroids enables high-throughput screening of their quality. However, sin...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2020.02.004
更新日期:2020-05-14 00:00:00
abstract:Introduction:Clinical outcomes after the implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in osteoarthritic knees have been rarely reported. Our study aimed to investigate clinical outcomes of osteoarthritic patients who underwent hUCB-MSC implantation. Methods:In this ca...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.10.003
更新日期:2020-01-14 00:00:00
abstract:Introduction:Toward the commercial production of human-induced pluripotent stem (hiPS) cells, the process design and operation have to be standardized. Considering the change in cell quality during filling of the hiPS cells into containers, lot sizing during filling also needs to be standardized. Methods:We present a ...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.04.012
更新日期:2019-05-17 00:00:00
abstract::A differentiation of human induced pluripotent stem cells (hiPSCs) into definitive endoderm linage is required for a preparation of metabolic organ derived cells. The differentiation consumed high-priced cytokines and small molecules, which have hampered the manufacturability of differentiated cells. Although the cyto...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.05.004
更新日期:2019-05-30 00:00:00
abstract::Human cells and tissue products belong to a relatively new class of medical products. Therefore, limited information is available on the classification and premarket evaluation of human cells and tissue products in the United States (US), the European Union (EU), and Japan. In this study, the definition, legislation, ...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2014.10.001
更新日期:2014-11-11 00:00:00
abstract:Introduction:Krüppel-like factor 4 (KLF4) is considered one of the Yamanaka factors, and recently, we and others have shown that KLF4 is one of the transcription factors essential for reprogramming non-human corneal epithelial cells (HCECs) into HCECs. Since epithelial to mesenchymal transition (EMT) suppression is vit...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.08.003
更新日期:2019-09-12 00:00:00
abstract:Introduction:We devised a strategy for the fabrication of an 'anatomy-mimicking' cylinder-type engineered trachea combined with cartilage engineering. The engineered BIOTUBEs are used to support the architecture of the body tissue, for long-segment trachea (>5 cm) with carinal reconstruction. The aim of the present stu...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.07.004
更新日期:2019-08-08 00:00:00
abstract:Introduction:Macrophages play an important role in regulating inflammation and tissue regeneration. It is known that anti-inflammatory macrophages play an important role for tissue regeneration. The objective of this study is to modify macrophages phenotypes for anti-inflammatory function by utilizing drug delivery tec...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.06.008
更新日期:2019-07-10 00:00:00
abstract:Introduction:To investigate the efficacy of the transplantation of autologous bone marrow-derived mesenchymal stem cells (BMSCs) under arthroscopy with microfracture (MFX) compared with microfracture alone. Methods:Eleven patients with a symptomatic articular cartilage defect of the knee were included in the study. Th...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.06.002
更新日期:2019-06-28 00:00:00
abstract::Cardiovascular disease is the leading cause of death globally. Cardiomyocytes (CMs) have poor regenerative capacity, and pharmacological therapies have limited efficacy in severe heart failure. Currently, there are several promising strategies for cardiac regeneration. The most promising approach to remuscularize fail...
journal_title:Regenerative therapy
pub_type: 杂志文章,评审
doi:10.1016/j.reth.2019.06.004
更新日期:2019-06-27 00:00:00
abstract::Human pluripotent stem cells, including human induced pluripotent stem cells (hiPSCs), are promising materials for regenerative medicine and cell transplantation therapy. However, tumorigenic potential of residual undifferentiated stem cells hampers their use in these therapies. Therefore, it is important to develop m...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2016.07.001
更新日期:2016-09-10 00:00:00
abstract:Background:Fibroblasts are indispensable for the fabrication of cell-sheet-based bioengineered cardiac tissues; however, whether cardiac fibroblasts can improve tissue properties for transplantation or in vitro models compared with other fibroblast types remains unclear. We compared the cell organization and functional...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2016.01.005
更新日期:2016-06-01 00:00:00
abstract:Introduction:Bone marrow mesenchymal stem cells (BMMSCs) ameliorate tissue damage after ischemic injury. Erythropoietin (Epo) has pleiotropic effects in addition to hematopoietic activity. The aim of this study was to investigate whether Epo enhanced cell survival and angiogenic effect of BMMSC implantation in rat limb...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2016.01.004
更新日期:2016-02-13 00:00:00
abstract::The development of biologically relevant three-dimensional (3D) tissue constructs is essential for the alternative methods of organ transplantation in regenerative medicine, as well as the development of improved drug discovery assays. Recent technological advances in hydrogel microfabrication, such as micromolding, 3...
journal_title:Regenerative therapy
pub_type: 杂志文章,评审
doi:10.1016/j.reth.2016.02.007
更新日期:2016-03-17 00:00:00
abstract::As a series of endeavors to establish suitable measures for the sound development of regenerative medicine using human stem cell-based products, we studied scientific principles, concepts, and basic technical elements to ensure the quality and safety of therapeutic products derived from autologous human iPS cells or i...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2015.06.002
更新日期:2015-11-24 00:00:00
abstract::The M2 isoform of pyruvate kinase, the final rate-limiting enzyme of aerobic glycolysis, is expressed during embryonic development. In contrast, the M1 isoform is expressed in differentiated cells due to alternative splicing. Here we investigated murine embryonic stem cells (ESCs) with Pkm1 or Pkm2 knock-in alleles. P...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2015.01.001
更新日期:2015-03-09 00:00:00
abstract:Objective:Myocardial infarction remains the number one killer disease worldwide. Cellular therapy using cardiac c-kit cells (CCs) are capable of regenerating injured heart. Previous studies showed mesenchymal stem cell-derived (MSC) extracellular matrices can provide structural support and are capable of regulating ste...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.03.006
更新日期:2019-05-10 00:00:00
abstract:Introduction:Triamcinolone acetonide (TA), a steroid, is often used clinically to prevent dysfunctions associated with fibrosis. The objective of this study was to examine whether TA can be suspended in a gelatin sheet for tissue engineering using a mouse skin wound model. Methods:TA was suspended in biodegradable gel...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2019.04.001
更新日期:2019-05-10 00:00:00
abstract::Magnetic targeting is a cell delivery system using the magnetic labeling of cells and the magnetic field; it has been developed for minimally invasive cell transplantation. Cell transplantation with both minimal invasiveness and high efficacy on tissue repair can be achieved by this system. Magnetic targeting has been...
journal_title:Regenerative therapy
pub_type: 杂志文章,评审
doi:10.1016/j.reth.2018.10.001
更新日期:2018-11-02 00:00:00
abstract:Introduction:Using a rat model of nontraumatic early arthritis induced by intra-articular administration of low-dose monoiodoacetic acid (MIA), we transplanted allogeneic chondrocyte sheets and examined the effects on tissue repair. Methods:MIA (0.2 mg/50 μl) was injected into the right knee of 20 male Wistar rats. Fo...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2018.07.003
更新日期:2018-08-24 00:00:00
abstract:Introduction:The anterior cruciate ligament (ACL) consists of various components, such as collagen, elastin fibres, and fibroblasts. Because ACL has a poor regenerative ability, ACL reconstruction need require the use of autologous tendons. In recent years, tissue-resident stem cells have been studied to promote ACL re...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2017.12.001
更新日期:2018-01-23 00:00:00
abstract:Introduction:Formation of cell spheres is an important procedure in biomedical research. A large number of high-quality cell spheres of uniform size and shape are required for basic studies and therapeutic applications. Conventional approaches, including the hanging drop method and suspension culture, are used for cell...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2017.08.003
更新日期:2017-09-11 00:00:00
abstract:Introduction:Large animal experiments are important for translational research in regenerative medicine. Recently, mini pigs have been used in large animal studies and surgical training. The use of multipotent mesenchymal stromal cell (MSC) sheets for the treatment of many diseases is increasing. The purpose of the pre...
journal_title:Regenerative therapy
pub_type: 杂志文章
doi:10.1016/j.reth.2017.02.001
更新日期:2017-04-03 00:00:00