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Role of laminin and cognate receptors in cholangiocarcinoma cell migration.

Abstract：

:Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell-matrix interaction. This study demonstrated laminin as the most potent attractant for CCA cell migration and the vast elevation of its receptor integrin β4 (ITGB4) in CCA cell lines. Besides, their high expressions in CCA tissues were correlated with lymphatic invasion and the presence of ITGB4 was also associated with short survival time. ITGB4 silencing revealed it as the receptor for laminin-induced HuCCA-1 migration, but KKU-213 utilized 37/67-kDa laminin receptor (LAMR) instead. These findings highlight the role of ITGB4 and LAMR in transducing laminin induction of CCA cell migration and the potential of ITGB4 as diagnostic and prognostic biomarkers for CCA.

journal_name

Cell Adh Migr

journal_title

Cell adhesion & migration

authors

Islam K,Thummarati P,Kaewkong P,Sripa B,Suthiphongchai T

doi

10.1080/19336918.2021.1924422

keywords:

["37\/67-kDa human laminin receptor","cell migration","cholangiocarcinoma","extracellular matrix","integrin β4","laminin"]

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

152-165

issue

1

eissn

1933-6918

issn

1933-6926

journal_volume

15

pub_type

杂志文章

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