Influence of adjunctive azithromycin on microbiological and clinical outcomes in periodontitis patients: 6-month results of randomized controlled clinical trial.


BACKGROUND:Our aim was to determine if azithromycin therapy, as an adjunct to scaling and root planing (SRP), decreases the number of pathobiontic subgingival plaque species and sites demonstrating pocket depth (PD) ≥ 5 mm and bleeding on probing (BOP) 6 months post-treatment. METHODS:In a double-blind randomized parallel-arm placebo-controlled trial, 40 patients received nonsurgical periodontal treatment in two sessions within 7 days. Patients then received systemic antibiotic therapy (n = 20, azithromycin 500 mg/day for 3 days) or placebo (n = 20). Pooled microbiologic samples were taken before and 6 months after therapy and analysed by established culture methods. The primary outcome variable was the number of sites with PD ≥ 5 mm and BOP at the 6-month re-evaluation. Using multivariate multilevel logistic regression, the effects of gender, age, antibiotic therapy, presence of P. gingivalis or A. actinomycetemcomitans, smoking, tooth being a molar and interdental location were evaluated. RESULTS:The number of sites with PD ≥ 5 mm and BOP after 6 months was similar in the test (Me = 4, IQR = 0-11) and control (Me = 5, IQR = 1-22) group. Adjunctive azithromycin treatment, compared to SRP alone, resulted in more frequent eradication of A. actinomycetemcomitans (p = 0.013) and C. rectus (p = 0.029), decreased proportion (p = 0.006) and total counts (p = 0.003) of P. gingivalis, and decreased proportion of C. rectus (p = 0.012). Both groups showed substantial but equivalent improvements in periodontal parameters, with no intergroups differences at initially shallow or deep sites. The logistic regression showed a lower odds ratio for healing of diseased sites on molars (OR = 0.51; p <  0,001). CONCLUSION:Despite significant changes in numbers of A. actinomycetemcomitans, P. gingivalis and C. rectus, patients with periodontitis do not benefit from adjunctive systemic azithromycin in terms of number of persisting sites with PD ≥ 5 mm and BOP. TRIAL REGISTRATION:EUDRA-CT: 2015-004306-42; , registered 17. 12. 2015.


BMC Oral Health


BMC oral health


Čuk K,Povšič K,Milavec S,Seme K,Gašperšič R




Has Abstract


2020-09-01 00:00:00












  • Confusion over live/dead stainings for the detection of vital microorganisms in oral biofilms--which stain is suitable?

    abstract:BACKGROUND:There is confusion over the definition of the term "viability state(s)" of microorganisms. "Viability staining" or "vital staining techniques" are used to distinguish live from dead bacteria. These stainings, first established on planctonic bacteria, may have serious shortcomings when applied to multispecies...

    journal_title:BMC oral health

    pub_type: 杂志文章,评审


    authors: Netuschil L,Auschill TM,Sculean A,Arweiler NB

    更新日期:2014-01-11 00:00:00

  • Big toenail and hair samples as biomarkers for fluoride exposure - a pilot study.

    abstract:BACKGROUND:Biomarkers can aid in detecting and preventing clinical disease through the recognition of change in biological samples. The objective of this case-control study was to further the knowledge on the use of big toenail and hair samples as biomarkers for fluoride exposure. METHODS:A total of 48 participants fr...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Elekdag-Turk S,Almuzian M,Turk T,Buzalaf MAR,Alnuaimi A,Dalci O,Darendeliler MA

    更新日期:2019-05-13 00:00:00

  • The association between denture self-satisfaction rates and OHRQoL - a follow-up study.

    abstract:BACKGROUD:The objectives of this study were to try to identify the key dimension in satisfaction from the combination of satisfaction clusters, and its effect on the change of OHRQoL(Oral Health-related Quality of Life) of elderly denture users. METHODS:This follow-up study was conducted in subjects aged 65 years and ...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Teng CJ,Lin SC,Chen JH,Chen Y,Kuo HC,Ho PS

    更新日期:2020-05-12 00:00:00

  • Clinical and socio-behavioral correlates of tooth loss: a study of older adults in Tanzania.

    abstract:BACKGROUND:Focusing 50 year olds and above, this study assessed the frequency, extent and correlates of tooth loss due to various reasons. Frequency and correlates of posterior occluding support was also investigated. METHOD:A cross-sectional household survey was conducted in Pwani region and in Dar es Salaam in 2004/...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Kida IA,Astrøm AN,Strand GV,Masalu JR

    更新日期:2006-03-15 00:00:00

  • Effects of dental treatment and systemic disease on oral health-related quality of life in Korean pediatric patients.

    abstract:BACKGROUND:The findings that not only dental caries but also systemic disease can exert a negative effect on oral health-related quality of life (OHRQoL), and that dental treatment can improve OHRQoL have been confirmed in multiple studies. The purpose of this study is to investigate the impact of dental treatment on O...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Song JS,Hyun HK,Shin TJ,Kim YJ

    更新日期:2018-05-29 00:00:00

  • Relationship between the genetic polymorphisms of vicR and vicK Streptococcus mutans genes and early childhood caries in two-year-old children.

    abstract:BACKGROUND:The VicRK two-component signalling system regulates virulence and cariogenicity in Streptococcus mutans (S. mutans). The purpose of this study was to explore the genetic polymorphisms of the vicR and vicK genes, which are associated with dental caries in children with S. mutans. METHODS:In this study, 121 (...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Zhuang PL,Yu LX,Liao JK,Zhou Y,Lin HC

    更新日期:2018-03-12 00:00:00

  • Protocol for a Randomised controlled trial to Evaluate the effectiveness and cost benefit of prescribing high dose FLuoride toothpaste in preventing and treating dEntal Caries in high-risk older adulTs (reflect trial).

    abstract:BACKGROUND:Dental caries in the expanding elderly, predominantly-dentate population is an emerging public health concern. Elderly individuals with heavily restored dentitions represent a clinical challenge and significant financial burden for healthcare systems, especially when their physical and cognitive abilities ar...

    journal_title:BMC oral health

    pub_type: 杂志文章,随机对照试验


    authors: Tickle M,Ricketts DJN,Duncan A,O'Malley L,Donaldson PM,Clarkson JE,Black M,Boyers D,Donaldson M,Floate R,Forrest MM,Fraser A,Glenny AM,Goulao B,McDonald A,Ramsay CR,Ross C,Walsh T,Worthington HV,Young L,Bonetti DL

    更新日期:2019-05-24 00:00:00

  • Risk indicators of aggressive periodontitis in a Jordanian population.

    abstract:BACKGROUND:Knowledge of the risk indicators of aggressive periodontitis (AgP) will help clinicians to better diagnose the disease, put a treatment plan that involves modification of modifiable risk indicators, understand non-modifiable risk indicators, and may potentially serve as an aid in developing preventive progra...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Ababneh KT,Maslamani MJ,Abbadi MS,Taha AH,Karasneh JA,Sa'di AG,Khader YS

    更新日期:2019-07-16 00:00:00

  • Reducing care-resistant behaviors during oral hygiene in persons with dementia.

    abstract:BACKGROUND:Nursing home residents with dementia are often dependent on others for mouth care, yet will react with care-resistant behavior when receiving assistance. The oral health of these elders deteriorates in the absence of daily oral hygiene, predisposing them to harmful systemic problems such as pneumonia, hyperg...

    journal_title:BMC oral health

    pub_type: 杂志文章,随机对照试验


    authors: Jablonski RA,Kolanowski A,Therrien B,Mahoney EK,Kassab C,Leslie DL

    更新日期:2011-11-19 00:00:00

  • Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: a systematic review and meta-analysis.

    abstract:BACKGROUND:This systematic review with meta-analyses sought to answer whether casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) provided a remineralizing benefit superior to that of nonintervention or placebo. METHODS:Following Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guide...

    journal_title:BMC oral health

    pub_type: 杂志文章,meta分析


    authors: Ma X,Lin X,Zhong T,Xie F

    更新日期:2019-12-30 00:00:00

  • Ethnic differences in oral health and use of dental services: cross-sectional study using the 2009 Adult Dental Health Survey.

    abstract:BACKGROUND:Oral health impacts on general health and quality of life, and oral diseases are the most common non-communicable diseases worldwide. Non-White ethnic groups account for an increasing proportion of the UK population. This study explores whether there are ethnic differences in oral health and whether these ar...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Arora G,Mackay DF,Conway DI,Pell JP

    更新日期:2016-06-16 00:00:00

  • Technical note on introducing a digital workflow for newborns with craniofacial anomalies based on intraoral scans - part I: 3D printed and milled palatal stimulation plate for trisomy 21.

    abstract:BACKGROUND:Advanced digital workflows in orthodontics and dentistry often require a combination of different software solutions to create patient appliances, which may be a complex and time-consuming process. The main objective of this technical note is to discuss treatment of craniofacial anomalies using digital techn...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Xepapadeas AB,Weise C,Frank K,Spintzyk S,Poets CF,Wiechers C,Arand J,Koos B

    更新日期:2020-01-23 00:00:00

  • Clinicopathological characteristics of oral squamous cell carcinoma in Northern Norway: a retrospective study.

    abstract:BACKGROUND:The main aim of the study was to evaluate if patients with oral squamous carcinomas in Northern Norway differ from patients in other countries with regard to clinicopathological characteristics and also study the influence of risk factors. Such a comparison is of demographical interest, and also important fo...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Rikardsen OG,Bjerkli IH,Uhlin-Hansen L,Hadler-Olsen E,Steigen SE

    更新日期:2014-08-18 00:00:00

  • Odontogenic tumors in Ethiopia: eight years retrospective study.

    abstract:BACKGROUND:Odontogenic tumor (OT) comprises a large heterogeneous group of lesions arising from tooth producing tissues or its remnants. Studies on OTs are scarce in Ethiopia. Thus, the present study aimed to assess the pattern of OTs in Ethiopia. METHODS:An 8 years retrospective study was conducted at the Dental and ...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Kebede B,Tare D,Bogale B,Alemseged F

    更新日期:2017-02-16 00:00:00

  • Effect of fluoride toothpastes on enamel demineralization.

    abstract:BACKGROUND:It was the aim of this study to investigate the effect of four different toothpastes with differing fluoride compounds on enamel remineralization. METHODS:A 3 x 3 mm window on the enamel surface of 90 human premolars was demineralized in a hydroxyethylcellulose solution at pH 4.8. The teeth were divided int...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Arnold WH,Dorow A,Langenhorst S,Gintner Z,Bánóczy J,Gaengler P

    更新日期:2006-06-15 00:00:00

  • A Danish version of the oral health impact profile-14 (OHIP-14): translation and cross-cultural adaptation.

    abstract:BACKGROUND:The Oral Health Impact Profile-14 (OHIP-14) questionnaire assesses quality of life related to people's perception of oral disorders on their well-being. However, a translated and validated Danish version of OHIP-14 is not yet available. The purpose of this pilot study was to translate and cross-culturally ad...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Gera A,Cattaneo PM,Cornelis MA

    更新日期:2020-09-10 00:00:00

  • Root form and canal morphology of maxillary first premolars of a Yemeni population.

    abstract:BACKGROUND:The purpose of this study was to investigate variations in the root canal systems of permanent maxillary first premolars in a Yemeni population using a clearing technique. METHODS:Two hundred fifty permanent maxillary first premolar teeth extracted from Yemeni individuals were collected. A small hole in the...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Senan EM,Alhadainy HA,Genaid TM,Madfa AA

    更新日期:2018-05-31 00:00:00

  • Does post-bleaching fluoridation affect the further demineralization of bleached enamel? An in vitro study.

    abstract:BACKGROUND:Topical fluoride agents have been shown to be the most effective method in treating demineralized enamel after in-office bleaching treatments. Thus, this study aimed to examine the effects of two different post-bleaching fluoridation agents: 1.5% titanium tetrafluoride (TiF(4)) (9200 ppm) and 2.1% sodium flu...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Kemaloğlu H,Tezel H,Ergücü Z

    更新日期:2014-09-06 00:00:00

  • A case-control study of determinants for high and low dental caries prevalence in Nevada youth.

    abstract:BACKGROUND:The main purpose of this study was to compare the 30% of Nevada Youth who presented with the highest Decayed Missing and Filled Teeth (DMFT) index to a cohort who were caries free and to national NHANES data. Secondly, to explore the factors associated with higher caries prevalence in those with the highest ...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Ditmyer M,Dounis G,Mobley C,Schwarz E

    更新日期:2010-11-11 00:00:00

  • Oral hygiene habits and possible transmission of COVID-19 among cohabitants.

    abstract:BACKGROUND:To find out whether misuse of dental hygiene, in terms of certain dental habits, may facilitate the spread of COVID-19 among cohabiting individuals. METHODS:302 COVID-19 infected (PCR +) subjects cohabiting with someone else at home were selected for an observational cross-sectional study. An anonymous onli...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: González-Olmo MJ,Delgado-Ramos B,Ruiz-Guillén A,Romero-Maroto M,Carrillo-Díaz M

    更新日期:2020-10-19 00:00:00

  • Presence of Helicobacter pylori in betel chewers and non betel chewers with and without oral cancers.

    abstract:BACKGROUND:Betel chewing has been shown to predispose to periodontal disease and oral cancer. Studies show that people with gum disease are more likely to test positive for Helicobacter pylori (H. pylori). It is not known if the lesions produced by betel quid and the resulting, chemical changes predispose to colonizati...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Fernando N,Jayakumar G,Perera N,Amarasingha I,Meedin F,Holton J

    更新日期:2009-09-22 00:00:00

  • A surrogate method for comparison analysis of salivary concentrations of Xylitol-containing products.

    abstract:BACKGROUND:Xylitol chewing gum has been shown to reduce Streptococcus mutans levels and decay. Two studies examined the presence and time course of salivary xylitol concentrations delivered via xylitol-containing pellet gum and compared them to other xylitol-containing products. METHODS:A within-subjects design was us...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Riedy CA,Milgrom P,Ly KA,Rothen M,Mueller G,Hagstrom MK,Tolentino E,Zhou L,Roberts MC

    更新日期:2008-02-11 00:00:00

  • Effect of mouthrinses on color stability of monolithic zirconia and feldspathic ceramic: an in vitro study.

    abstract:BACKGROUND:Patients susceptible to periodontal disease and dental caries, including those who undergo fixed prosthodontic treatments use chemical plaque control agents. However, these mouthrinses may result in adverse effects such as discoloration of the restorative materials. The aim of this study was to compare the c...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Derafshi R,Khorshidi H,Kalantari M,Ghaffarlou I

    更新日期:2017-11-07 00:00:00

  • Resting salivary flow independently associated with oral malodor.

    abstract:BACKGROUND:Dryness of the oral cavity is considered one cause of oral malodor. However, it is unclear which of the factors regulating the wetness of the oral cavity are involved in oral malodor development. This study investigated the effects of salivary flow and oral mucosal moisture on oral malodor. METHODS:The stud...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Suzuki N,Fujimoto A,Yoneda M,Watanabe T,Hirofuji T,Hanioka T

    更新日期:2016-07-19 00:00:00

  • Anti-inflammatory effects of olanexidine gluconate on oral epithelial cells.

    abstract:BACKGROUND:Periodontitis is a biofilm-induced chronic inflammatory condition of the periodontium. Chemokines produced by the innate and acquired immune responses play a significant role in disease progression. Reducing biofilm formation and inflammatory response caused by chemokines is vital for preventing and treating...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Nii T,Yumoto H,Hirota K,Miyake Y

    更新日期:2019-11-08 00:00:00

  • Contextual and individual determinants of tooth loss in adults: a multilevel study.

    abstract:BACKGROUND:Tooth loss represents a known marker of health inequality. The association between tooth loss and unfavorable socioeconomic conditions is evident when analyzed at an individual level. However, the effects of contextual characteristics on tooth loss need to be better investigated and understood. The objective...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Roberto LL,Silveira MF,de Paula AMB,Ferreira E Ferreira E,Martins AMEBL,Haikal DS

    更新日期:2020-03-17 00:00:00

  • A new method for assessment of nickel-titanium endodontic instrument surface roughness using field emission scanning electronic microscope.

    abstract:BACKGROUND:To introduce a new method for measurement of surface roughness of the endodontic instrument, before and after instrumentation, using the Field Emission Scanning Electronic Microscope (FE-SEM) combined with the ImageJ software. METHODS:Twenty J-shape resin blocks were divided into two groups, ten blocks of e...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Van Pham K,Vo CQ

    更新日期:2020-08-31 00:00:00

  • Influence of obesity on the outcome of non-surgical periodontal therapy - a systematic review.

    abstract:BACKGROUND:Obesity and periodontitis are important chronic health problems. Obesity is associated with an increased prevalence of periodontitis. Whether obesity also affects the outcome of non-surgical periodontal therapy is to date still unclear. METHODS:A systematic review of studies referenced in SCOPUS, MEDLINE, P...

    journal_title:BMC oral health

    pub_type: 杂志文章,评审


    authors: Gerber FA,Sahrmann P,Schmidlin OA,Heumann C,Beer JH,Schmidlin PR

    更新日期:2016-09-02 00:00:00

  • Creating research and development awareness among dental care professionals by use of strategic communication: a 12-year intervention study.

    abstract:BACKGROUND:Despite the availability of contemporary research advances, only a limited fraction is implemented into dental practice. One possible way to facilitate this process is to stimulate the research and development (R&D) awareness and interest with aid of strategic communication. METHODS:The aim of the study was...

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: Morténius H,Twetman S

    更新日期:2017-12-29 00:00:00

  • Self-perceived halitosis influences social interactions.

    abstract:BACKGROUND:To determine the impact of self-perceived halitosis on social interactions, and the effect of using an oral rinse for management of halitosis. METHODS:A survey among a representative sample of the Dutch population (n = 1082), and a pre-post study among a sample of consecutive coming-by volunteers (n = 292)....

    journal_title:BMC oral health

    pub_type: 杂志文章


    authors: de Jongh A,van Wijk AJ,Horstman M,de Baat C

    更新日期:2016-03-09 00:00:00