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Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers.

Abstract：

:We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.

journal_name

Emerg Microbes Infect

journal_title

Emerging microbes & infections

authors

Martínez-Sanz J,Jiménez D,Martínez-Campelo L,Cruz R,Vizcarra P,Sánchez-Conde M,Ron R,Rodríguez M,Herrera S,Moreno S,López-Huertas MR,Serrano-Villar S

doi

10.1080/22221751.2021.1902755

keywords:

["COVID-19","SARS-CoV-2","genetic variants","single-nucleotide polymorphism","susceptibility"]

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

493-496

issue

1

issn

2222-1751

journal_volume

10

pub_type

信件

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