Abstract:
BACKGROUND:The fetal anomaly ultrasound only detects 65 to 81 % of the patients with congenital heart disease, making it the most common structural fetal anomaly of which a significant part is missed during prenatal life. Therefore, we need a reliable non-invasive diagnostic method which improves the predictive value for congenital heart diseases early in pregnancy. Fetal electrocardiography could be this desired diagnostic method. There are multiple technical challenges to overcome in the conduction of the fetal electrocardiogram. In addition, interpretation is difficult due to the organisation of the fetal circulation in utero. We want to establish the normal ranges and values of the fetal electrocardiogram parameters in healthy fetuses of 18 to 24 weeks of gestation. METHODS/DESIGN:Women with an uneventful singleton pregnancy between 18 and 24 weeks of gestation are asked to participate in this prospective cohort study. A certified and experienced sonographist performs the fetal anomaly scan. Subsequently, a fetal electrocardiogram recording is performed using dedicated signal processing methods. Measurements are performed at two institutes. We will include 300 participants to determine the normal values and 95 % confidence intervals of the fetal electrocardiogram parameters in a healthy fetus. We will evaluate the fetal heart rate, segment intervals, normalised amplitude and the fetal heart axis. Three months postpartum, we will evaluate if a newborn is healthy through a questionnaire. DISCUSSION:Fetal electrocardiography could be a promising tool in the screening program for congenital heart diseases. The electrocardiogram is a depiction of the intimate relationship between the cardiac nerve conduction pathways and the structural morphology of the fetal heart, and therefore particularly suitable for the detection of secondary effects due to a congenital heart disease (hypotrophy, hypertrophy and conduction interruption).
journal_name
BMC Pregnancy Childbirthjournal_title
BMC pregnancy and childbirthauthors
Verdurmen KMJ,Lempersz C,Vullings R,Schroer C,Delhaas T,van Laar JOEH,Oei SGdoi
10.1186/s12884-016-1021-xsubject
Has Abstractpub_date
2016-08-17 00:00:00pages
227issn
1471-2393pii
10.1186/s12884-016-1021-xjournal_volume
16pub_type
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journal_title:BMC pregnancy and childbirth
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1186/s12884-016-0922-z
更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-03-21 00:00:00
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pub_type: 杂志文章
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更新日期:2018-09-29 00:00:00
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pub_type: 杂志文章
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更新日期:2019-07-05 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-09-05 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2393-14-300
更新日期:2014-09-02 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-20 00:00:00
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pub_type: 杂志文章
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更新日期:2019-02-12 00:00:00
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pub_type: 杂志文章
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更新日期:2021-01-05 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2010-12-14 00:00:00