BET and BRAF inhibitors act synergistically against BRAF-mutant melanoma.

abstract：BACKGROUND:Whether adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations is associated with a reduced risk of pancreatic cancer remains controversial. Additionally, no study has investigated this association in the US population. Hence, we inves...

journal_title：Cancer medicine

authors： Zhang ZQ,Li QJ,Hao FB,Wu YQ,Liu S,Zhong GC

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:To investigate the effect of miR-107 on the growth and metastasis of gastric cancer (GC) and elucidate the probable mechanisms. METHODS:The expression of miR-107 and FAT4 in GC tissues and cells were detected using qRT-PCR. Bioinformatics and dual luciferase reporter gene assays were used to analyze the relati...

journal_title：Cancer medicine

authors： Wang L,Li K,Wang C,Shi X,Yang H

更新日期：2019-09-01 00:00:00

abstract：:Circular RNAs (circRNAs) are identified to play an evident role in many human cancers, such as gastric cancer. However, the potential mechanisms underlying the circRNA-induced pathogenesis in gastric cancers are still elusive. The present study is designed to unfold the mechanism by which circRNAs involve in gastric c...

journal_title：Cancer medicine

authors： Xia T,Pan Z,Zhang J

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Radiotherapy is the recommended treatment after breast-conserving surgery (BCS) for early-stage breast cancer (BC). However, there is no clear evidence whether radiotherapy after BCS improves the survival of elderly women diagnosed with early-stage hormone receptor-positive (HR+) BC. The aim of this study wa...

journal_title：Cancer medicine

authors： Ali AA,Tawk R,Xiao H,Campbell E,Semykina A,Montero AJ,Mogos M,Diaby V

更新日期：2019-01-01 00:00:00

abstract：:Intensity-modulated radiation therapy (IMRT) is frequently utilized after prostatectomy without strong evidence for an improvement in outcomes compared to conformal radiation therapy (RT). We analyzed a large group of patients treated with RT after radical prostatectomy (RP) to compare complications after IMRT and CRT...

journal_title：Cancer medicine

authors： Crandley EF,Hegarty SE,Hyslop T,Wilson DD,Dicker AP,Showalter TN

更新日期：2014-04-01 00:00:00

abstract：:Nuclear receptor coactivator 1 (NCOA1) plays crucial roles in the regulation of gene expression mediated by a wide spectrum of steroid receptors such as androgen receptor (AR), estrogen receptor α (ER α), and estrogen receptor β (ER β). Therefore, dysregulations of NCOA1 have been found in a variety of cancer types. H...

journal_title：Cancer medicine

authors： Wang L,Li W,Li K,Guo Y,Liu D,Yao Z,Lin X,Li S,Jiang Z,Liu Q,Jiang Y,Zhang B,Chen L,Zhou F,Ren H,Lin D,Zhang D,Yeung SJ,Zhang H

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Increasing evidence has validated the crucial role of alternative splicing (AS) in tumors. However, comprehensive investigations on the entirety of AS and their clinical value in glioblastoma (GBM) are lacking. METHODS:The AS profiles and clinical survival data related to GBM were obtained from The Cancer G...

journal_title：Cancer medicine

authors： Xie ZC,Wu HY,Dang YW,Chen G

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:People living with HIV/AIDS (PLWH) have an excess risk for head and neck squamous cell carcinoma (HNSCC) compared to the general U.S. population, but little is known about HIV-specific risk factors associated with the incidence and outcomes HNSCC. We aim to identify clinical and HIV-specific risk factors ass...

journal_title：Cancer medicine

authors： Mazul AL,Hartman C,Kramer J,White DL,Royse K,Raychaudhury S,Sandulache V,Ahmed ST,Richardson P,Sikora AG,Chiao E

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Downstream of tyrosine kinase 6 (DOK6), which is specifically expressed in the nervous system, was previously recognized as an adapter only in neurite outgrowth. Recent studies also demonstrated the potential role of DOK6 in solid tumors such as gastric cancer and breast cancer. However, previous studies of ...

journal_title：Cancer medicine

authors： Sun GK,Tang LJ,Zhou JD,Xu ZJ,Yang L,Yuan Q,Ma JC,Liu XH,Lin J,Qian J,Yao DM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Increasing studies report that lncRNAs are dysregulated in hepatocellular carcinoma (HCC), which might function as significant diagnostic biomarkers of HCC. LncRNA MSC-AS1 has been newly discovered in several cancers. However, its biological effect in HCC remains to be clearly elucidated. The ...

journal_title：Cancer medicine

authors： Cao C,Zhong Q,Lu L,Huang B,Li J,Meng L,Wei H

更新日期：2020-07-01 00:00:00

abstract：:The aim of this study was to report 3-year outcomes of toxicity, cosmesis, and local control using a once daily fractionation scheme (49.95 Gy in 3.33 Gy once daily fractions) for accelerated partial breast irradiation (APBI) using three-dimensional conformal radiotherapy (3D-CRT). Between July 2008 and August 2010, w...

journal_title：Cancer medicine

authors： Goyal S,Daroui P,Khan AJ,Kearney T,Kirstein L,Haffty BG

更新日期：2013-12-01 00:00:00

abstract：:For elderly patients with glioblastoma multiforme (GBM), randomized trials have shown similar survival with hypofractionated short-course radiotherapy (SCRT) compared to conventionally fractionated long-course radiotherapy (LCRT). We evaluated the adoption of SCRT along with associated factors and survival in a nation...

journal_title：Cancer medicine

authors： Mak KS,Agarwal A,Qureshi MM,Truong MT

更新日期：2017-06-01 00:00:00

abstract：:Antibody-drug conjugates (ADCs) belong to a promising class of biopharmaceuticals in which target-killing of tumor cells was achieved by marrying the potency of the cytotoxic payload with the tumor specificity of the antibody. Here we developed a novel ADC (ZV0508) that targets 5T4 oncofetal antigen, which is overexpr...

journal_title：Cancer medicine

authors： Shi B,Wu M,Li Z,Xie Z,Wei X,Fan J,Xu Y,Ding D,Akash SH,Chen S,Cao S

更新日期：2019-04-01 00:00:00

abstract：:Patients were identified from a population-based prospective study of 4990 individuals with symptoms associated with colorectal cancer (CRC). A total of 244 CRC tissue samples were available for immunohistochemical staining of uPAR, semiquantitatively scored at the invasive front, and in the tumor core on cancer cells...

journal_title：Cancer medicine

authors： Illemann M,Laerum OD,Hasselby JP,Thurison T,Høyer-Hansen G,Nielsen HJ,Danish Study Group on Early Detection of Colorectal Cancer.,Christensen IJ

更新日期：2014-08-01 00:00:00

abstract：:Preoperative use of metformin in obese women with endometrioid endometrial cancer (EEC) reduces tumor proliferation and inhibits the mammalian target of rapamycin pathway, though is only effective in select cases. This study sought to identify a predictive and/or pharmacodynamic proteomic signature of metformin respon...

journal_title：Cancer medicine

authors： Bateman NW,Teng PN,Hope E,Hood BL,Oliver J,Ao W,Zhou M,Wang G,Tommarello D,Wilson K,Litzy T,Conrads KA,Hamilton CA,Darcy KM,Casablanca Y,Maxwell GL,Bae-Jump V,Conrads TP

更新日期：2020-02-01 00:00:00

abstract：:The role of stereotactic body radiation therapy for the elderly with advanced or medically inoperable pancreatic cancer was still debated. Therefore, we evaluated the value of stereotactic body radiation therapy and its association with survival of those patients. A total of 417 elderly patients were retrospectively r...

journal_title：Cancer medicine

authors： Zhu X,Li F,Ju X,Cao F,Cao Y,Fang F,Qing S,Shen Y,Jia Z,Zhang H

更新日期：2017-10-01 00:00:00

abstract：:Granulosa cell tumors (GCTs) carry a risk of recurrence also at an early stage, but reliable prognostic factors are lacking. We assessed clinicopathological prognostic factors and the prognostic roles of the human epidermal growth factor receptors (HER 2-4) and the transcription factor GATA4 in GCTs. We conducted a lo...

journal_title：Cancer medicine

authors： Färkkilä A,Andersson N,Bützow R,Leminen A,Heikinheimo M,Anttonen M,Unkila-Kallio L

更新日期：2014-06-01 00:00:00

abstract：:Toward developing a model system for investigating the role of the microenvironment in the radioresistance of glioblastoma (GBM), human glioblastoma stem-like cells (GSCs) were grown in coculture with human astrocytes. Using a trans-well assay, survival analyses showed that astrocytes significantly decreased the radio...

journal_title：Cancer medicine

authors： Rath BH,Wahba A,Camphausen K,Tofilon PJ

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Appropriate depression care is a cancer-care priority. However, many cancer survivors live with undiagnosed and untreated depression. Prostate cancer survivors may be particularly vulnerable, but little is known about their access to depression care. The goal of this study was to describe patterns and predic...

journal_title：Cancer medicine

authors： Erim DO,Bensen JT,Mohler JL,Fontham ETH,Song L,Farnan L,Delacroix SE,Peters ES,Erim TN,Chen RC,Gaynes BN

更新日期：2019-07-01 00:00:00

abstract：:Primary bone marrow lymphoma (PBML) represents non-Hodgkin lymphoma (NHL) that primarily arises in the bone marrow (BM) without lymphadenopathy. This condition has various definitions and can be masked by prolonged fever, leading to delayed diagnosis. We aimed to identify clinical features and risk indicators of PBML....

journal_title：Cancer medicine

authors： Wang HY,Yang CF,Chiou TJ,Gau JP,Chen PM,Tsai CY,Hsu HC,Wang FD,Liu JH,Hsiao LT

更新日期：2018-08-01 00:00:00

abstract：:The least toxic time (LTT) of irinotecan varied by up to 8 hours according to sex and genetic background in mice. The translational relevance was investigated within a randomized trial dataset, where no LTT stood out significantly in the whole population. 130 male and 63 female eligible patients with metastatic colore...

journal_title：Cancer medicine

authors： Innominato PF,Ballesta A,Huang Q,Focan C,Chollet P,Karaboué A,Giacchetti S,Bouchahda M,Adam R,Garufi C,Lévi FA

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Male breast cancer is uncommon, delay in seeking medical attention often results in late presentation and poor prognosis. METHODS:Retrospective review of a prospectively maintained database was performed. Patients who were still having regular follow-up were contacted for telephone interview. RESULTS:In ...

journal_title：Cancer medicine

authors： Co M,Lee A,Kwong A

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:The overuse of medical tests leads to higher costs, wasting of resources, and the potential for overdiagnosis of disease. This study was designed to determine whether the patients of family doctors who order more routine medical tests are diagnosed with more cancers. METHOD:A retrospective population-based ...

journal_title：Cancer medicine

authors： Hall SF,Webber C,Groome PA,Booth CM,Nguyen P,DeWit Y

更新日期：2019-02-01 00:00:00

abstract：:Although histologic analysis is the gold standard for diagnosing follicular lymphoma (FL) transformation, many patients are diagnosed with transformation by clinical factors as biopsy specimens often cannot be obtained. Despite the frequency of clinical diagnosis, no clinical assessment tool has yet been established f...

journal_title：Cancer medicine

authors： Shichijo T,Maruyama D,Yamauchi N,Maeshima AM,Sugano M,Yuda S,Tajima K,Kurihara H,Shimada K,Suzuki T,Toyoda K,Makita S,Fukuhara S,Munakata W,Suzuki T,Kobayashi Y,Taniguchi H,Minami Y,Izutsu K,Tobinai K

更新日期：2020-12-01 00:00:00

abstract：:An increasing number of publications had reported the association between single-nucleotide polymorphisms (SNPs) and esophageal cancer (EC) risk in the past decades. Results from these publications were controversial. We used PubMed, Medline, and Web of Science to identify meta-analysis articles published before 30 Ju...

journal_title：Cancer medicine

authors： Tian J,Liu C,Liu G,Zuo C,Chen H

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Cancer of unknown primary (CUP) is a distinct clinicopathological entity with poor prognosis, frequently resistant to chemotherapy. Comprehensive genomic profiling (CGP) by next-generation sequencing potentially identifies novel treatment options for CUP patients. The objective of this study was to determine...

journal_title：Cancer medicine

authors： Binder C,Matthes KL,Korol D,Rohrmann S,Moch H

更新日期：2018-09-01 00:00:00

abstract：:Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence. PGCC have the potential to generate progeny through primitive or cleavage-like division, which a...

journal_title：Cancer medicine

authors： White-Gilbertson S,Lu P,Jones CM,Chiodini S,Hurley D,Das A,Delaney JR,Norris JS,Voelkel-Johnson C

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Many previous studies reported secular trend of lung cancer incidence and mortality, but little is known about the possible reasons for these trends. METHODS:Data were obtained from Shanghai Cancer Registry. Age-standardized rates were calculated and average annual percent changes (AAPCs) were evaluated by ...

journal_title：Cancer medicine

authors： Xie L,Qian Y,Liu Y,Li Y,Jia S,Yu H,Wang C,Qian B,Bao P

更新日期：2020-04-01 00:00:00

abstract：:Long noncoding RNA NUTM2A-AS1 has been shown to be dysregulated in non-small cell lung carcinoma. To date, it is unclear whether NUTM2A-AS1 plays a role in gastric cancer progression. The purpose of this study is to elucidate the molecular mechanism of the role of NUTM2A-AS1 in gastric cancer. mRNA and protein levels ...

journal_title：Cancer medicine

authors： Wang J,Yu Z,Wang J,Shen Y,Qiu J,Zhuang Z

更新日期：2020-12-01 00:00:00

abstract：BACKGROUNDS:Myeloma-related bone disease (MBD) is a common complication of multiple myeloma (MM), which can both decrease life quality and influence the prognosis of the patients. We have found that CCN1 stimulated proliferation and differentiation of osteoblasts in MM in vitro and in vivo, while its mechanism still re...

journal_title：Cancer medicine

authors： Yan S,Liu H,Liu Z,Peng F,Jiang F,Li L,Fu R

更新日期：2020-01-01 00:00:00