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Pregnancy complications and birth outcomes among women experiencing nausea only or nausea and vomiting during pregnancy in the Norwegian Mother and Child Cohort Study.

Abstract：

BACKGROUND:To compare pregnancy complications and birth outcomes for women experiencing nausea and vomiting in pregnancy, or nausea only, with symptom-free women. METHODS:Pregnancies from the Norwegian Mother and Child Cohort Study (n = 51 675), a population-based prospective cohort study, were examined. Data on nausea and/or vomiting during gestation and birth outcomes were collected from three questionnaires answered between gestation weeks 15 and 30, and linked with data from the Medical Birth Registry of Norway. Chi-squared tests, one way analysis of variance, multiple linear and logistic regression analyses were used. RESULTS:Women with nausea and vomiting (NVP) totalled 17 070 (33%), while 20 371 (39%) experienced nausea only (NP), and 14 234 (28%) were symptom-free (SF). When compared to SF women, NVP and NP women had significantly increased odds for pelvic girdle pain (adjusted odds ratio, aOR, 2.26, 95% confidence interval, 95% CI, 2.09-2.43, and aOR 1.90, 95% CI, 1.76-2.05, respectively) and proteinuria (aOR 1.50, 95% CI 1.38-1.63, and 1.20, 95% CI 1.10-1.31, respectively). Women with NVP also had significantly increased odds for high blood pressure (aOR 1.40, 95% CI 1.17-1.67) and preeclampsia (aOR 1.13, 95% CI 1.01-1.27). Conversely, the NVP and NP groups had significantly reduced odds for unfavourable birth outcomes such as low birth weight infants (aOR 0.72, 95% CI 0.60-0.88, and aOR 0.73, 95 % CI 0.60-0.88, respectively) and small for gestational age infants (aOR 0.78, 95% CI 0.73-0.84, and aOR 0.87, 95% CI 0.81-0.93, respectively). CONCLUSIONS:We found that women with NVP and NP are more likely to develop pregnancy complications, yet they display mostly favourable delivery and birth outcomes.

journal_name

BMC Pregnancy Childbirth

journal_title

BMC pregnancy and childbirth

authors

Chortatos A,Haugen M,Iversen PO,Vikanes Å,Eberhard-Gran M,Bjelland EK,Magnus P,Veierød MB

doi

10.1186/s12884-015-0580-6

subject

Has Abstract

pub_date

2015-06-23 00:00:00

pages

138

issn

1471-2393

pii

10.1186/s12884-015-0580-6

journal_volume

pub_type

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Pregnancy complications and birth outcomes among women experiencing nausea only or nausea and vomiting during pregnancy in the Norwegian Mother and Child Cohort Study.