On the origin of human adipocytes and the contribution of bone marrow-derived cells.

abstract：:Epidemiological studies have shown that maternal undernutrition during pregnancy (MU) leads to intrauterine growth retardation and low birth weight, and may predispose individuals to the development of metabolic syndrome symptoms later in life such as overweight. Some clues from a model of prenatal maternal 70% food-r...

journal_title：Adipocyte

authors： Lukaszewski MA,Delahaye F,Vieau D,Breton C

更新日期：2012-01-01 00:00:00

abstract：:Adipose tissue (AT) hypoxia occurs in obese humans and mice. Acute hypoxia in adipocytes causes dysregulation of adipokine secretion with an increase in inflammatory factors and diminished adiponectin release. O2 levels in humans range between 3 and 11% revealing that conventional in vitro culturing at ambient air and...

journal_title：Adipocyte

authors： Famulla S,Schlich R,Sell H,Eckel J

更新日期：2012-07-01 00:00:00

abstract：:Calorie restriction (CR) extends lifespan in species ranging from yeast to mammals. There is evidence that CR also protects against aging-related diseases in non-human primates. This has led to an intense interest in the development of CR-mimetics to harness the beneficial effects of CR to treat aging-related diseases...

journal_title：Adipocyte

authors： Chung JH

更新日期：2012-10-01 00:00:00

abstract：:Visceral fat has long been associated with the development of insulin resistance. Although the mechanism is not well understood, it has been suggested that an increase in this fat depot results in an elevation in portal vein levels of free fatty acids and/or adipokines, adversely affecting hepatic glucose production. ...

journal_title：Adipocyte

authors： Kim SP

更新日期：2013-01-01 00:00:00

abstract：:Obesity and associated metabolic diseases are sexually dimorphic. To provide better diagnosis and treatment for both sexes, it is of interest to identify the factors that underlie male/female differences in obesity. Traditionally, sexual dimorphism has been attributed to effects of gonadal hormones, which influence nu...

journal_title：Adipocyte

authors： Link JC,Chen X,Arnold AP,Reue K

更新日期：2013-04-01 00:00:00

abstract：:Increased adipocyte size and number are associated with many of the adverse effects observed in metabolic disease states. While methods to quantify such changes in the adipocyte are of scientific and clinical interest, manual methods to determine adipocyte size are both laborious and intractable to large scale investi...

journal_title：Adipocyte

authors： Osman OS,Selway JL,Kępczyńska MA,Stocker CJ,O'Dowd JF,Cawthorne MA,Arch JR,Jassim S,Langlands K

更新日期：2013-07-01 00:00:00

abstract：:The posttranslational modification (PTM) in protein occurs in a regiospecific manner. In addition, the most commonly occurring PTMs involve similar residues in proteins such as acetylation, ubiquitylation, methylation and sumoylation at the lysine residue and phosphorylation and O-GlcNAc modification at serine/threoni...

journal_title：Adipocyte

authors： Ande SR,Padilla-Meier GP,Mishra S

更新日期：2013-10-01 00:00:00

abstract：:During the last years the existence of metabolically active brown adipose tissue in adult humans has been widely accepted by the research community. Its unique ability to dissipate chemical energy stored in triglycerides as heat makes it an attractive target for new drugs against obesity and its related diseases. Henc...

journal_title：Adipocyte

authors： Lidell ME,Betz MJ,Enerbäck S

更新日期：2014-01-01 00:00:00

abstract：:Obesity is recognized as a low-grade chronic inflammatory state which involves a chemokine network contributing to a variety of diseases. As a first step toward understanding the roles of the obesity-driven chemokine network, we used a 3T3-L1 cell differentiation model to identify the chemokine profiles elicited durin...

journal_title：Adipocyte

authors： Kabir SM,Lee ES,Son DS

更新日期：2014-04-01 00:00:00

abstract：:Adipogenesis is regulated by a complex interplay between transcription factors, in concert with-among others-transcriptional cofactors, signaling cascades and miRNAs. Several studies have implicated the transcriptional cofactor and acetyltransferase Tip60 in PPARγ signaling and adipocyte differentiation. Since Tip60 p...

journal_title：Adipocyte

authors： Gao Y,Kalkhoven E

更新日期：2014-04-01 00:00:00

abstract：:Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis. The dissipation of energy in brown adipose tissue (BAT) is in stark contrast to white adipose tissue (WAT) which is the body's ...

journal_title：Adipocyte

authors： Christian M

更新日期：2014-10-30 00:00:00

abstract：:Recent data indicate that cell size fluctuation, a key property in adipocyte pathophysiology primarily dependent on lipid storage, is linked to a novel function of lipid droplet organelles acting as mechano-active organelles to regulate cell membrane remodeling and caveolae dynamics. ...

journal_title：Adipocyte

authors： Le Lay S,Briand N,Dugail I

更新日期：2014-12-17 00:00:00

abstract：:Obesity is associated with endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) in adipose tissue. In this study we identify physiological triggers of ER stress and of the UPR in adipocytes in vitro. We show that two markers of adipose tissue remodelling in obesity, glucose starvatio...

journal_title：Adipocyte

authors： Mihai AD,Schröder M

更新日期：2015-01-12 00:00:00

abstract：:The prevalence of obesity has risen to an unprecedented level. According to World Health Organization, over 500 million adults, equivalent to 10%-14% of the world population, were obese with a body mass index (BMI) of 30 kg/m(2) or greater in 2008.(1) This rising prevalence and earlier onset of obesity is believed to ...

journal_title：Adipocyte

authors： Yang X,Bi P,Kuang S

更新日期：2014-12-10 00:00:00

abstract：:The extracellular matrix (ECM) plays important roles in maintaining adequate adipose tissue function and in metabolic regulation. Here we have examined the organization of a relatively unexplored adipose tissue ECM component, elastin and its response to diet induced obesity in mice. Additionally, we have explored the ...

journal_title：Adipocyte

authors： Martinez-Santibanez G,Singer K,Cho KW,DelProposto JL,Mergian T,Lumeng CN

更新日期：2015-04-20 00:00:00

abstract：:In the past decades, obesity and associated metabolic complications have reached epidemic proportions. For the study of these pathologies, a number of animal models have been developed. However, a direct comparison between Wistar and Sprague-Dawley (SD) Rat as models of high-fat (HF) diet-induced obesity has not been ...

journal_title：Adipocyte

authors： Marques C,Meireles M,Norberto S,Leite J,Freitas J,Pestana D,Faria A,Calhau C

更新日期：2015-07-15 00:00:00

abstract：:The circadian clock is an essential time-keeping mechanism that entrains internal physiology to environmental cues. Despite the well-established link between the molecular clock and metabolic homeostasis, an intimate interplay between the clock machinery and the metabolically active brown adipose tissue (BAT) is only ...

journal_title：Adipocyte

authors： Nam D,Yechoor VK,Ma K

更新日期：2015-08-12 00:00:00

abstract：:The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue (WAT), a process called browning, represents a promising route to treat metabolic disorders. While surgical procedu...

journal_title：Adipocyte

authors： Longchamp A,Tao M,Bartelt A,Ding K,Lynch L,Hine C,Corpataux JM,Kristal BS,Mitchell JR,Ozaki CK

更新日期：2015-11-20 00:00:00

abstract：:The global epidemic in obesity and metabolic syndrome requires novel approaches to tackle. White adipose tissue, traditionally seen as a passive energy-storage organ, can be induced to take on certain characteristics of brown fat in a process called browning. The "browned" white adipose tissue, or beige fat, is a pote...

journal_title：Adipocyte

authors： Lo KA,Ng PY,Kabiri Z,Virshup D,Sun L

更新日期：2016-03-22 00:00:00

abstract：:Adipose tissue dysfunction correlates with the development of diabetes. Mice with an adipocyte-specific deletion of the SUMO-specific protease SENP1 develop symptoms of type-1 diabetes mellitus (T1DM). Peri-pancreatic adipocytes (PATs) exert both systemic and paracrine effects on pancreases function. Our recent studie...

journal_title：Adipocyte

authors： Shao L,Feng B,Zhang Y,Zhou H,Ji W,Min W

更新日期：2016-03-17 00:00:00

abstract：:Retinoic acid (RA) is essential for early developmental processes and stem cell differentiation, but less is known about its contributions to adult tissues and stem cells including adipose tissue. We previously demonstrated that many genes involved in RA synthesis and downstream pathway are differentially expressed in...

journal_title：Adipocyte

authors： Perumal J,Sriram S,Lim HQ,Olivo M,Sugii S

更新日期：2016-10-10 00:00:00

abstract：:The mechanisms by which estradiol modulates adipose lipolysis are poorly understood. We sought to measure basal and β3-stimulated indices of lipoysis (FFAs, glycerol) in vivo in E2 deficient or supplemented rats, and ex vivo with direct acute E2 exposure. For 2 weeks, ovariectomized (OVX) and OVX rats treated with a d...

journal_title：Adipocyte

authors： MacDonald TL,MacPherson R,Castellani L,Cervone D,Anderson E,Wright DC,Dyck DJ

更新日期：2017-04-03 00:00:00

abstract：:Upper-body adiposity is associated with increased metabolic disease risk, while lower-body adiposity is paradoxically protective. Efforts to understand the underlying mechanisms require appropriate and reproducible in vitro culture models. We have therefore generated immortalised (im) human preadipocyte (PAD) cell lin...

journal_title：Adipocyte

authors： Todorčević M,Hilton C,McNeil C,Christodoulides C,Hodson L,Karpe F,Pinnick KE

更新日期：2017-01-02 00:00:00

abstract：:Understanding adipose tissue heterogeneity is hindered by the paucity of methods to analyze mature adipocytes at the single cell level. Here, we report a system for analyzing live adipocytes from different adipose depots in the adult mouse. Single cell suspensions of buoyant adipocytes were separated from the stromal ...

journal_title：Adipocyte

authors： Boumelhem BB,Assinder SJ,Bell-Anderson KS,Fraser ST

更新日期：2017-04-03 00:00:00

abstract：:Intestinal alkaline phosphatase 3 (AKP3) is an enzyme that was reported to play a role in lipid metabolism and to prevent high fat diet-induced metabolic syndrome in mice. To investigate a potential functional role of AKP3 in diet-induced adiposity and metabolic health, we have kept male and female wild-type or AKP3 d...

journal_title：Adipocyte

authors： Vercalsteren E,Vranckx C,Lijnen HR,Hemmeryckx B,Scroyen I

更新日期：2018-01-01 00:00:00

abstract：:Obesity and diabetes are at an epidemic rate, as well as growing incidences of gestational diabetes mellitus (GDM) which causes pregnancy risks, and harm in both maternal and child health. It remains unclear which molecular mechanisms are driving the functional differences between visceral and subcutaneous fat and how...

journal_title：Adipocyte

authors： Rancourt RC,Ott R,Schellong K,Melchior K,Ziska T,Henrich W,Plagemann A

更新日期：2019-12-01 00:00:00

abstract：:The 3T3-L1 pre-adipocyte cell line is widely used to study the fat cell differentiation in vitro. Researchers also use this cell model to study obesity and insulin resistance. We surveyed the literature, the gene expression omnibus and the sequence read archive for RNA-Seq and ChIP-Seq datasets of MDI-induced 3T3-L1 d...

journal_title：Adipocyte

authors： Ahmed M,Kim DR

更新日期：2019-12-01 00:00:00

abstract：:Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT...

journal_title：Adipocyte

authors： Rodriguez-Ayala E,Gallegos-Cabrales EC,Gonzalez-Lopez L,Laviada-Molina HA,Salinas-Osornio RA,Nava-Gonzalez EJ,Leal-Berumen I,Escudero-Lourdes C,Escalante-Araiza F,Buenfil-Rello FA,Peschard VG,Laviada-Nagel A,Silva E,Veloz-Garza

更新日期：2020-12-01 00:00:00

abstract：:Cathepsin L1 (CTSL1) and B (CTSB) are lysosomal proteases, of which the expression and activity are impaired in adipose tissue (AT) of obese rodents, indicating AT lysosomal dysfunction. Here we assess the relation between abdominal subcutaneous AT (SCAT) CTSL1 and CTSB gene expression (qRT-PCR), body composition and ...

journal_title：Adipocyte

authors： Xu Q,Mariman ECM,Goossens GH,Blaak EE,Jocken JWE

更新日期：2020-01-01 00:00:00

abstract：:Hyperinsulinemia is the hallmark of the development of insulin resistance and precedes the diagnosis of type 2 diabetes. Here we evaluated the effects of prolonged exposure (≥4 days) to high insulin doses (150 nM) in vitro in two adipose cell types, mouse 3T3-L1 and human SGBS. Chronic insulin treatment significantly ...

journal_title：Adipocyte

authors： Rossi A,Eid M,Dodgson J,Davies G,Musial B,Wabitsch M,Church C,Hornigold DC

更新日期：2020-12-01 00:00:00