Abstract:
BACKGROUND:Colorectal cancer represents the most common malignancy of the gastrointestinal tract. Owing to differences in dietary habits and lifestyle, this neoplasm is more common in industrialized countries than in developing ones. Evidence from a wide range of sources supports the assumption that the link between diet and colorectal cancer may be due to an imbalance of the intestinal microflora. DISCUSSION:Probiotic bacteria are live microorganisms that, when administered in adequate amounts, confer a healthy benefit on the host, and they have been investigated for their protective anti-tumor effects. In vivo and molecular studies have displayed encouraging findings that support a role of probiotics in colorectal cancer prevention. SUMMARY:Several mechanisms could explain the preventive action of probiotics against colorectal cancer onset. They include: alteration of the intestinal microflora; inactivation of cancerogenic compounds; competition with putrefactive and pathogenic microbiota; improvement of the host's immune response; anti-proliferative effects via regulation of apoptosis and cell differentiation; fermentation of undigested food; inhibition of tyrosine kinase signaling pathways.
journal_name
BMC Surgjournal_title
BMC surgeryauthors
Uccello M,Malaguarnera G,Basile F,D'agata V,Malaguarnera M,Bertino G,Vacante M,Drago F,Biondi Adoi
10.1186/1471-2482-12-S1-S35subject
Has Abstractpub_date
2012-01-01 00:00:00pages
S35issn
1471-2482pii
1471-2482-12-S1-S35journal_volume
12 Suppl 1pub_type
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